Casein kinase 1α has a non-redundant and dominant role within the CK1 family in melanoma progression

Influence of the modulation of CK1 isoform expression on cell viability and cell cycle. (A) Inhibition of isoform specific CK1-activity via combined siRNA mediated knockdown of CK1α, CK1δ and CK1ε. SbCl2 (left diagram) and SKMEL19 (right diagram) cells were transduced with isoform specific siRNA or a non-silencing control and cell growth was monitored for 4 days using the MUH viability assay. Fluorescence intensities were normalized (100 %) to the start point at 24 h post transfection of the siRNA. Shown is the mean with SD of hexatuplicates. (B) Cell cycle analysis after knockdown of CK1 isoforms in SbCl2 and SKMel19 melanoma cells. After ice-cold ethanol fixation melanoma tumor cells were stained with 50 μg/ml propidium iodide containing RNase in PBS for 30 min and analyzed in a LSRII flow cytometer (BD). (C) Cell cycle analysis at 48 h after induction of CK1 isoforms revealed a significant subG1 apoptotic population only after overexpression of CK1α. (TIF 701 kb

La biblioteca del Estado de Sajonia y la biblioteca de la Universidad de Dresde y su colección especializada de arte contemporáneo, fotografía y diseño industrial y gráfico

La Biblioteca del Estado de Sajonia tuvo como origen la biblioteca de los príncipes electores de este territorio histórico, quienes siempre manifestaron un gran interés por el arte. La bibliografía sobre arte ha tenido desde sus comienzos un protagonismo especial. La colección ha ido enriqueciéndose con el paso del tiempo, especialmente a partir de que se le reconociera la condición de biblioteca especializada en 1966 y la de biblioteca central de arte y música de la República Democrática de Alemania en 1983. Dada la carencia de divisas extranjeras que padeció esta república, hubo que acudir compensatoriamente al intercambio de publicaciones. Los dieciocho volúmenes de la "Bibliografía de Bellas Artes", editada por la biblioteca, ofrecieron un buen material para el mismo

Migration, Geschlecht, Gewalt: Überlegungen zu einem intersektionellen Gewaltbegriff

"Politische Maßnahmen gegen und wissenschaftliche Diskussionen um sogenannte 'traditionsbedingte' Gewalt gegen Frauen in westlichen Einwanderungsgesellschaften machen einen intersektionellen Gewaltbegriff nötig, der der kulturalisierenden Falle entkommt und nachhaltigen Gewaltschutz zu denken ermöglicht, ohne bestimmte minorisierte Gruppen abzuwerten und von Gewalt betroffene Frauen zu viktimisieren. Der Text schlägt im Kontext eines weiten feministischen Gewaltbegriffs eine Re-Theoretisierung von Gewalt gegen Frauen vor. Ein feministischer Gewaltbegriff sollte erstens das Zusammenspiel von Gewaltstrukturen und -diskursen, zweitens die Interaktion von Ungleichheitsstrukturen in Minderheitengruppen und der Mehrheitsgesellschaft sowie drittens die Interaktion von Ungleichheits- und Gewaltstrukturen an der Schnittstelle von Geschlecht, Kultur, Ethnizität/Nationalität, Religion und Klasse umfassen." (Autorenreferat)"Political measures against as well as scientific debates about so-called 'traditional harmful practices' against women in western immigration countries put the necessity of an intersectional concept of violence on the feminist scientific agenda, Such a concept should aim to escape the trap of culturalizing the 'Other'. It should also build the ground to guarantee sustainable harm reduction without stigmatizing minority groups nor victimizing women affected by violence. In the context of a broad feminist notion of violence the article suggests the re-theorization of the concept of violence against women. This conceptualization should include first the interplay of structures and discourses of violence, second the interaction of structures of inequality between minority groups and dominant society, and third the intersection of structures of inequality and violence between gender, culture, ethnicity, religion, and class." (author's abstract

Engel der Geschichte: ein Rückblick auf die Zukunft feministischer Politikwissenschaft

Festrede anlässlich des Symposiums "Kritischem Denken Raum geben. 20 Jahre Femina Politica - Zeitschrift für feministische Politikwissenschaft" am 30. Juni 2017 im Wissenschaftszentrum Berlin für Sozialforschung

Geschlecht, Emotion und Politik

"The women's movement and feminism tend to intimize, to destructure and therefore to depolitizise the public sphere. This accusation is quite popular in the german speaking feminist academic community. What happened to the politics of subjectivity, to the feminist political strategy of overcoming the split between public and privat as well as rationality and emotion? I argue that feminist political science as well as malestream political science is 'emotionblind'. This means that emotions are treated as forms of perception, of acting and evaluation that are different from political perceptions and political action. Emotions are outside of the political space – either making the field of politics chaotic (malestream political science) or conzeptualized as a means to feminize and humanize politics (some feminist approaches to female political partizipation). These contradicting appraisals of emotion, gender and politics is putting the connection of gender, emotion and politics on the agenda of feminist political theory. I suggest an approach which conceptualizes emotion as socially and politically constructed. The recent notion of emotion was constructed at the same point in history as gender, with the formation of the capitalist state and the bourgeois class. Gender and emotion build a historical dispositive (Foucault) which emotionalizes women and the private sphere and de-emotionalizes men and the public sphere. The separation of women and men as well as rationality and emotion is a means of control. The notion of an emotional dispositive says that political space is structurally gendered and emotionalized: The dominant mode of beaurocracy – rationality – is the organized hierarchy of male over female as well as rationality over emotion. The Weberian seperation of beaurocracy and (charismatic) politics constructs the public sphere as male and seperates 'good' emotions (Vaterlandsliebe/ love for the country) from 'bad' emotions (sexuality)." (author's abstract