Casein kinase 1α has a non-redundant and dominant role within the CK1 family in melanoma progression

Influence of the modulation of CK1 isoform expression on cell viability and cell cycle. (A) Inhibition of isoform specific CK1-activity via combined siRNA mediated knockdown of CK1α, CK1δ and CK1ε. SbCl2 (left diagram) and SKMEL19 (right diagram) cells were transduced with isoform specific siRNA or a non-silencing control and cell growth was monitored for 4 days using the MUH viability assay. Fluorescence intensities were normalized (100 %) to the start point at 24 h post transfection of the siRNA. Shown is the mean with SD of hexatuplicates. (B) Cell cycle analysis after knockdown of CK1 isoforms in SbCl2 and SKMel19 melanoma cells. After ice-cold ethanol fixation melanoma tumor cells were stained with 50 μg/ml propidium iodide containing RNase in PBS for 30 min and analyzed in a LSRII flow cytometer (BD). (C) Cell cycle analysis at 48 h after induction of CK1 isoforms revealed a significant subG1 apoptotic population only after overexpression of CK1α. (TIF 701 kb

La biblioteca del Estado de Sajonia y la biblioteca de la Universidad de Dresde y su colección especializada de arte contemporáneo, fotografía y diseño industrial y gráfico

La Biblioteca del Estado de Sajonia tuvo como origen la biblioteca de los príncipes electores de este territorio histórico, quienes siempre manifestaron un gran interés por el arte. La bibliografía sobre arte ha tenido desde sus comienzos un protagonismo especial. La colección ha ido enriqueciéndose con el paso del tiempo, especialmente a partir de que se le reconociera la condición de biblioteca especializada en 1966 y la de biblioteca central de arte y música de la República Democrática de Alemania en 1983. Dada la carencia de divisas extranjeras que padeció esta república, hubo que acudir compensatoriamente al intercambio de publicaciones. Los dieciocho volúmenes de la "Bibliografía de Bellas Artes", editada por la biblioteca, ofrecieron un buen material para el mismo

Doing Gender in Public Services: Affective Labour of Employment Agents

The restructuring of state bureaucracies into service organi zations and the new welfare state paradigm of activation have changed the work requirements of front-line workers in public employment agencies across Europe. Public employment agents are less engaged in bureaucratic labour, but have to perform service work. They use affective means to motivate and to monitor and sanction jobseekers. This article provides evidence that these transformations in Aus tria, Germany and Switzerland did not suspend the gender ing of public service work. We discovered four typical modes of affectively enacting the state: both male and female employment agents follow feminized service work pat terns or masculinized entrepreneurial norms. To prevent a possible loss of their professional status, some employment agents reinterpret affective labour as professional service work that demands high expertise. Others resist the activa tion paradigm by performing traditionally feminized care work or by still adhering to affect-neutral male bureaucratic work

Engel der Geschichte. Ein Rückblick auf die Zukunft feministischer Politikwissenschaft

Festrede anlässlich des Symposiums „Kritischem Denken Raum geben. 20 Jahre Femina Politica – Zeitschrift für feministische Politikwissenschaft“ am 30. Juni 2017 im Wissenschaftszentrum Berlin für Sozialforschun

Engel der Geschichte: ein Rückblick auf die Zukunft feministischer Politikwissenschaft

Festrede anlässlich des Symposiums "Kritischem Denken Raum geben. 20 Jahre Femina Politica - Zeitschrift für feministische Politikwissenschaft" am 30. Juni 2017 im Wissenschaftszentrum Berlin für Sozialforschung