Demographic data.

<p>Table listing the demographic data in the groups. Values in medians and IQ range. (CFI/CFS; Cystic fibrosis, pancreas insufficient/sufficient. HC; Healthy controls).</p><p>* Median (range).</p><p>Demographic data.</p

Liver-pancreas signal intensity ratio.

<p>Box plots displaying outliers, 95% confidence intervals, Interquartile ranges and median values for the liver pancreas signal-intensity ratio in corresponding groups. (SIR: Signal intensity ratio, CFI/CFS: Cystic fibrosis pancreas insufficient/ sufficient. HC: Healthy controls).</p

Lipomatosis VAS.

<p>Fig. displaying the rate of pancreas lipomatosis. White column display all patients in the groups. Dark columns display the number of subjects scored as VAS ≥3 (CFI/CFS: Cystic fibrosis pancreas insufficient/ sufficient. HC: Healthy controls).</p

Inclusion flow chart.

<p>The figure displays the inclusion and exclusion of cystic fibrosis patients and healthy controls. (CF: Cystic fibrosis. CFI/CFS: Cystic fibrosis insufficient/ sufficient. HC: Healthy controls).</p

Pancreas ultrasonography.

<p>The figure is displaying a normal pancreas in pancreas sufficient patient (left) and a typical hyper echoic pancreas in an insufficient patient (Right). The Visual score graded echogenicity 1 for the left pancreas and 4 for the right pancreas. The image to the right display region of interest (ROI) for Echo intensity measures (1: Liver, 2: pancreas, 3: Vessel (superior mesenteric vein)).</p

Visual analogue scale (VAS).

<p>Table defining the visual analogue scale for signal intensity after Worthen & Al (37).</p><p>Visual analogue scale (VAS).</p

Signal-intensity ratios.

<p>Table displaying echo intensity ratios. Values are expressed as medians (IQ range). (SIR; Signal intensity ratio).</p><p>Signal-intensity ratios.</p

Maternal age at delivery, lung function and asthma in offspring : a population-based survey

There is limited information about potential impact of maternal age on the respiratory health of offspring. We investigated the association of maternal age at delivery with adult offspring's lung function, respiratory symptoms and asthma, and potential differences according to offspring sex.10 692 adults from 13 countries participating in the European Community Respiratory Health Survey (ECRHS) II responded to standardised interviews and provided lung function measurements and serum for IgE measurements at age 25-55 years. In logistic and linear multilevel mixed models we adjusted for participants' characteristics (age, education, centre, number of older siblings) and maternal characteristics (smoking in pregnancy, education) while investigating for differential effects by sex. Maternal age was validated in a subsample using data from the Norwegian birth registry.Increasing maternal age was associated with increasing forced expiratory volume in 1 s (2.33 mL per year, 95% CI 0.34-4.32 mL per year), more consistent in females (p; trend; 0.025) than in males (p; trend; 0.14). Asthma (OR 0.85, 95% CI 0.79-0.92) and respiratory symptoms (OR 0.87, 95% CI 0.82-0.92) decreased with increasing maternal age (per 5 years) in females, but not in males (p; interaction; 0.05 and 0.001, respectively). The results were consistent across centres and not explained by confounding factors.Maternal ageing was related to higher adult lung function and less asthma/symptoms in females. Biological characteristics in offspring related to maternal ageing are plausible and need further investigation