Disease activity and cognition in rheumatoid arthritis : an open label pilot study

Acknowledgements This work was supported in part by NIHR Newcastle Biomedical Research Centre. Funding for this study was provided by Abbott Laboratories. Abbott Laboratories were not involved in study design; in the collection, analysis and interpretation of data; or in the writing of the report.Peer reviewedPublisher PD

The Incidence of X-ray selected AGN in Nearby Galaxies

We present the identification and analysis of an unbiased sample of AGN that lie within the local galaxy population. Using the MPA-JHU catalogue (based on SDSS DR8) and 3XMM DR7 we define a parent sample of 25,949 local galaxies ($z \leq 0.33$). After confirming that there was strictly no AGN light contaminating stellar mass and star-formation rate calculations, we identified 917 galaxies with central, excess X-ray emission likely originating from an AGN. We analysed their optical emission lines using the BPT diagnostic and confirmed that such techniques are more effective at reliably identifying sources as AGN in higher mass galaxies: rising from 30% agreement in the lowest mass bin to 93% in the highest. We then calculated the growth rates of the black holes powering these AGN in terms of their specific accretion rates ($\propto L_X/M_*$). Our sample exhibits a wide range of accretion rates, with the majority accreting at rates $\leq 0.5\%$ of their Eddington luminosity. Finally, we used our sample to calculate the incidence of AGN as a function of stellar mass and redshift. After correcting for the varying sensitivity of 3XMM, we split the galaxy sample by stellar mass and redshift and investigated the AGN fraction as a function of X-ray luminosity and specific black hole accretion rate. From this we found the fraction of galaxies hosting AGN above a fixed specific accretion rate limit of $10^{-3.5}$ is constant (at $\approx 1\%$) over stellar masses of $8 < \log \mathrm{M_*/M_\odot} < 12$ and increases (from $\approx 1\%$ to $10\%$) with redshift.Comment: 18 pages, 10 figures, 2 appendices. Accepted for publication in MNRA

A Monitor of Beam Polarization Profiles for the TRIUMF Parity Experiment

TRIUMF experiment E497 is a study of parity violation in pp scattering at an energy where the leading term in the analyzing power is expected to vanish, thus measuring a unique combination of weak-interaction flavour conserving terms. It is desired to reach a level of sensitivity of 2x10^-8 in both statistical and systematic errors. The leading systematic errors depend on transverse polarization components and, at least, the first moment of transverse polarization. A novel polarimeter that measures profiles of both transverse components of polarization as a function of position is described.Comment: 19 pages LaTeX, 10 PostScript figures. To appear in Nuclear Instruments and Methods in Physics Research, Section

A monomeric, heterobimetallic complex with an unsupported Mg−Fe bond

The phosphinimine, trimethylsilyl-substituted BIPM ligand [BIPM = bis(iminophosphorano)methanide] has been used to stabilise CH(Ph2PNSiMe3)2MgFe(η5-C5H5)(CO)2 (1), which is a structurally authenticated complex exhibiting a direct, unsupported bond between an alkaline earth metal and a transition metal. The FTIR-measured carbonyl stretching frequencies for this complex suggest that there is a polarisation of charge from the transition metal fragment to the magnesium centre. The presence of a polar metal-metal bond in 1 is confirmed by DFT calculations, which suggest that the Mg−Fe bond is predominantly ionic in nature

The incidence of AGN in galaxies with different stellar population ages

It has been argued that recycled gas from stellar mass loss in galaxies might serve as an important fuelling source for black holes (BHs) in their centers. Utilizing spectroscopic samples of galaxies from the Sloan Digital Sky Survey (SDSS) at $z = 0-0.35$ and the Large Early Galaxy Astrophysics Census (LEGA-C) survey at $z = 0.6-1$ that have X-ray coverage from XMM-Newton or Chandra, we test this stellar mass loss fuelling scenario by investigating how AGN activity and BH growth vary with the break strength at 4000 $\r{A}$, $\rm D_{n}4000$ (which is closely related to the age of stellar populations), as younger galaxies are considered to have higher stellar mass loss rates. We found that when controlling for host-galaxy properties, the fraction of log $L_{\rm X}$/$M_\star$ > 32 (which roughly corresponds to Eddington ratios $\gtrsim 1$%) AGN and sample-averaged black hole accretion rate ($\rm \overline{BHAR}$) decrease with $\rm D_{n}4000$ among $\rm D_{n}4000$ $\lesssim$ 1.9 galaxies, suggesting a higher level of AGN activity among younger galaxies, which supports the stellar mass loss fuelling scenario. For the oldest and most massive galaxies at $z = 0-0.35$, this decreasing trend is not present anymore. We found that, among these most massive galaxies at low redshift, the fraction of low specific-accretion-rate (31 $<$ log $L_{\rm X}$/$M_\star$ $<$ 32) AGNs increases with $\rm D_{n}4000$, which may be associated with additional fuelling from hot halo gas and/or enhanced accretion capability.Comment: 24 pages, 28 figures. Accepted for publication in MNRA

Co-crystallisation as a modular approach to the discovery of spin-crossover materials

Herein we present co-crystallisation as a strategy for materials discovery in the field of switchable spin crossover (SCO) systems. Using [Fe(3-bpp)2]·2A (where 3-bpp = 2,6-bis(pyrazol-3-yl)pyridine, A = BF4−/PF6−) as a starting point, a total of 11 new cocrystals have been synthesised with five different dipyridyl coformers. Eight of these systems show spin crossover behaviour, and all show dramatically different switching properties from the parent complex. The cocrystals have been studied by variable temperature single-crystal X-ray diffraction and SQUID magnetometry to develop structure–property relationships. The supramolecular architecture of the cocrystals depends on the properties of the coformer. With linear, rigid coformer molecules leading to 1D supramolecular hydrogen-bonded chains, while flexible coformers form 2D sheets and bent coformers yield 3D network structures. The SCO behaviour of the cocrystals can be modified through changing the coformer and thus co-crystallisation presents a rapid, facile and highly modular tool for the discovery of new switchable materials. The wider applicability of this strategy to the design of hybrid multifunctional materials is also discussed

Random-matrix theory of amplifying and absorbing resonators with PT or PTT' symmetry

We formulate gaussian and circular random-matrix models representing a coupled system consisting of an absorbing and an amplifying resonator, which are mutually related by a generalized time-reversal symmetry. Motivated by optical realizations of such systems we consider a PT or a PTT' time-reversal symmetry, which impose different constraints on magneto-optical effects, and then focus on five common settings. For each of these, we determine the eigenvalue distribution in the complex plane in the short-wavelength limit, which reveals that the fraction of real eigenvalues among all eigenvalues in the spectrum vanishes if all classical scales are kept fixed. Numerically, we find that the transition from real to complex eigenvalues in the various ensembles display a different dependence on the coupling strength between the two resonators. These differences can be linked to the level spacing statistics in the hermitian limit of the considered models.Comment: 19 pages, 9 figure