12 research outputs found
Novel resveratrol derivatives have diverse effects on the survival, proliferation and senescence of primary human fibroblasts
A facile, stereoselective, one-pot synthesis of resveratrol derivatives
BACKGROUND: Compounds based on trans-1,2-diphenylethene are the subject of intense interest both for their optical properties and as potential leads for drug discovery, as a consequence of their anticancer, anti-inflammatory and antioxidant properties. Perhaps the best known of these is trans-3,5,4′-trihydroxystilbene (resveratrol), that has been identified as a promising lead in the search for anti-ageing therapeutics. RESULTS: We report here a new, convenient, one-pot stereo-selective synthesis of resveratrol and other trans-stilbene derivatives. A wide range of known and novel “Resveralogues” were synthesised by using this simple protocol, including examples with electron donating and electron withdrawing substituents, in uniformly high yield. The structures of all compounds were confirmed by standard methods including (1)H and (13)C NMR, IR and High Resolution Mass spectroscopy. CONCLUSIONS: We have established a simple and convenient protocol for resveralogue synthesis. It is readily scalable, and sufficiently robust and simple for ready use in automated synthesis or for library development of resveralogues. This supersedes previously reported synthetic methods that required inert conditions, extensive purification and/or costly reagents. [Figure: see text
Total carotenoid content, α-carotene and β-carotene, of landrace pumpkins (Cucurbita moschata Duch): A preliminary study
AbstractLandrace pumpkins occur in nature and their potential as source of pro-vitamin A may be investigated in order to be used in conventional plant breeding or biofortification programs, aiming to increase the total carotenoids and β-carotene contents. The objective of the study was to determine the total carotenoid, α-carotene, β-carotene and its isomers and contents in two landrace samples (A and B) of raw pumpkins (Cucurbita moschata) to verify its seed production potential. High Performance Liquid Chromatography and UV/Visible spectrophotometry were used to determine α-carotene, β-carotene and its isomers, and total carotenoid contents, respectively. All analyses were carried out in triplicate. The results showed mean total carotenoid contents of 404.98 in sample A, and 234.21μg/g in sample B. The α-carotene contents varied from 67.06 to 72.99μg/g in samples A and B, respectively. All E-β-carotene was the most abundant isomer found varying from 244.22 to 141.95μg/g in samples A and B, respectively. The 9 and 13-Z-β-carotene isomers were still found in low concentrations in both analyzed landrace samples. The content of β-carotene in raw sample A showed to be promising for the production of seeds for cultivation and consumption
The effects resveratrol and new novel analogues of this stilbene have on sirt1 activation
Additional file 6: Figure S4. of Small molecule modulation of splicing factor expression is associated with rescue from cellular senescence
The effect of manipulation of the ERK pathway with chemical inhibitors and agonists on cellular senescence. (TIFF 193Â kb
Additional file 4: Figure S2. of Small molecule modulation of splicing factor expression is associated with rescue from cellular senescence
Live cell capture image following resveratrol treatment. (TIFF 243Â kb
Additional file 6: Figure S4. of Small molecule modulation of splicing factor expression is associated with rescue from cellular senescence
The effect of manipulation of the ERK pathway with chemical inhibitors and agonists on cellular senescence. (TIFF 193Â kb
Additional file 2: Table S2. of Small molecule modulation of splicing factor expression is associated with rescue from cellular senescence
Splicing factor expression and changes in alternative splicing following treatment with resveratrol analogues. (DOCX 19Â kb