Ossifying fibroma of the maxillary sinus at the Kara (Togo) Teaching Hospital

SummaryIntroductionOssifying fibroma of the jaw is a benign tumorous disease, somewhat rare and aggressive. It frequently targets the mandible, but seldom the maxillary.Case studyThe present study reports the first case of left maxillary sinus fibroma treated at the Kara Teaching Hospital in North Togo. It occurred in a 29-year-old patient who experienced slow-growing tumefaction of the left maxillary sinus, resulting in deformation of the left side of the face in the maxillary region and ipsilateral nasal obstruction. Orthopantomography showed a displacement of teeth 21, 22, and 23 with an abnormal degree of opacity at the dental roots. The CT scan of the nose and sinuses revealed a tumorous lesion of expanding bony density increasing in volume at the outer wall of the left maxillary sinus, of regular shape that contained microscopic calcifications, extending into the ipsilateral orbital floor and pushing the surrounding soft tissues forward without invading them. The histopathological examination of the tumor confirmed the diagnosis of ossifying fibroma.DiscussionOssifying fibroma or fibrous osteoma is a rare and benign lesion developing insidiously with a polymorphous aspect. Of unknown etiology, most frequently located in the mandible, it is differentiated from other types of fibroma in its clinical, radiological, and histological aspects. However, only examination of the gross specimen can provide the final diagnosis. Treatment requires surgery.ConclusionSurgical treatment entailed the complete macroscopic enucleoresection. Recovery has been favorable at 2 years of follow-up

Complementary approaches to understanding the plant circadian clock

Circadian clocks are oscillatory genetic networks that help organisms adapt to the 24-hour day/night cycle. The clock of the green alga Ostreococcus tauri is the simplest plant clock discovered so far. Its many advantages as an experimental system facilitate the testing of computational predictions. We present a model of the Ostreococcus clock in the stochastic process algebra Bio-PEPA and exploit its mapping to different analysis techniques, such as ordinary differential equations, stochastic simulation algorithms and model-checking. The small number of molecules reported for this system tests the limits of the continuous approximation underlying differential equations. We investigate the difference between continuous-deterministic and discrete-stochastic approaches. Stochastic simulation and model-checking allow us to formulate new hypotheses on the system behaviour, such as the presence of self-sustained oscillations in single cells under constant light conditions. We investigate how to model the timing of dawn and dusk in the context of model-checking, which we use to compute how the probability distributions of key biochemical species change over time. These show that the relative variation in expression level is smallest at the time of peak expression, making peak time an optimal experimental phase marker. Building on these analyses, we use approaches from evolutionary systems biology to investigate how changes in the rate of mRNA degradation impacts the phase of a key protein likely to affect fitness. We explore how robust this circadian clock is towards such potential mutational changes in its underlying biochemistry. Our work shows that multiple approaches lead to a more complete understanding of the clock

Novel P53 mutations detected by FAMA in colorectal cancers

Background: The aim of the study was to identify p53 gene mutations by FAMA (fluorescence-assisted mismatch analysis) in colorectal cancers. Patients and methods: Analytical scanning of the p53 gene (exons 5\u20139) was performed in colon cancer samples from 44 consecutive patients by FAMA. FAMA is a semiautomatic scanning approach based on the chemical cleavage of the mismatch in fluorescently labeled heteroduplex DNA, obtained from the combination of a normal and a mutated allele. FAMA has already shown optimal levels of diagnostic accuracy and sensitivity in detecting gene mutations (nucleotide substitutions, insertions/deletions) both at the germline and somatic level. The peculiar feature of FAMA is its ability to detect and localize mutations, by a redundant pattern of signals due to fluorescent DNA fragments generated by chemical cleavage. Moreover, previous data have demonstrated that normal contaminating DNA from stromal cells in the sample does not affect the sensitivity of the procedure, leading to the identification of the mutation even when the ratio mutant/normal allele is 10%. Results: Eighteen mutations (12 missense, one nonsense, two deletions, three nucleotide substitutions at the level of the splice-junctions) and two polymorphisms were detected by FAMA in 17 patients (39%) and then confirmed by automated sequence analysis. Six of 18 mutations (33%) were not previously reported for colon cancer samples and two of 18 lesions (11%) were identified as novel p53 mutations. Conclusions: Analytical scanning of the p53 gene by FAMA in DNA from colon cancer samples provides a sensitive, accurate and specific diagnostic procedure for routine clinical application

EKSEKUSI PUTUSAN ARBITRASE DALAM PENYELESAIAN PERKARA PERDATA

Tujuan penelitian adalah untuk mengetahui dan memahami hambatan-hambatan dalam eksekusi putusan pengadilan dalam perkara perdata dan untuk mengetahui dan memahami eksekusi putusan arbitrase dalam perkara perdata. Dengan metode penelitian yuridis normatif, kesimpulan yang didapat: 1. Hambatan-hambatan eksekusi putusan pengadilan dalam perkara perdata adalah hambatan teknis atau faktor non yuridis, hambatan yuridis, faktor perlawanan fisik dan faktor intervensi penguasa. Hambatan teknis atau non yuridis seperti biaya eksekusi yang sangat mahal melebihi ketentuan yang berlaku. Hambatan eksekusi yang bersifat yuridis adalah adanya permintaan peninjauan kembali sebagai upaya hukum luar biasa, padahal telah melalui upaya hukum biasa yakni banding dan kasasi. Faktor perlawanan fisik yang dilakukan oleh termohon dan keluarganya, kerabat, orang-orang bayaran menghadang petugas pengadilan menjalankan eksekusi. Faktor intervensi penguasa dapat berasal dari pejabat eksekutif maupun pejabat di lingkungan Pengadilan Tinggi maupun Mahkamah Agung terutama jika termohon eksekusi mempunyai kedudukan ekonomi dan politis kuat sengaja mendekati pejabat pengadilan untuk meminta penundaan eksekusi. 2.Eksekusi atau pelaksanaan putusan arbitrase dalam perkara perdata harus terlebih dahulu didaftarkan kepada Ketua Panitera Pengadilan Negeri setempat dengan menyerahkan lembar asli atau salinan putusan arbitrase oleh arbiter atau biasanya setelah 30 hari setelah putusan arbitrase diucapkan. Eksekusi terhadap putusan arbitrase dapat dilakukan dengan menyita barang milik termohon eksekusi yang lazim disebut sebagai sita eksekusi (executorial beslag).   Kata Kunci : Eksekusi Putusan Arbitras

Genetic diversity among early provitamin A quality protein maize inbred lines and the performance of derived hybrids under contrasting nitrogen environments

Open Access JournalInformation on population structure and genetic diversity of germplasm in a breeding programme is useful because it enhances judicious utilisation of genetic resources to achieve breeding objectives. Seventy early maturing provitamin A (PVA) quality protein maize (QPM) inbreds developed by the IITA- maize improvement programme were genotyped using 8171 DArTseq markers. Furthermore, 96 hybrids derived from 24 selected inbreds plus four checks were evaluated under low-N and optimal environments in Nigeria during 2016 and 2017. Genotypic and phenotypic data of inbreds and hybrids respectively, were analysed to (i) assess the level of genetic dissimilarities and population structure of the inbreds, and (ii) investigate the grain yield performance of derived hybrids under low-N, optimal and across environments

Samarco?s socio-environmental disaster : tracing controversies from a pedagogical office with newspapers.

O presente trabalho apresenta o rastreio das controv?rsias que se emergiram a partir do desenvolvimento de uma oficina pedag?gica de produ??o de textos jornal?sticos, com uma turma em ano final do ensino m?dio da rede p?blica de ensino. Nesse caminho, utilizamos como suporte te?rico-anal?tico os princ?pios da Teoria Ator-Rede (TAR) para analisarmos as circula??es, fluxos e movimenta??es, a partir das transla??es entre os actantes, no caso deste trabalho, alunos, professor e jornais. Decorridas as an?lises observamos que a partir dos momentos de discuss?es, debates e produ??o escrita realizada, muitas foram as controv?rsias que se emergiram. Ressaltamos ainda, que por meio da oficina pedag?gica com jornais, os alunos puderam discutir as nuances do desastre, bem como discutir e refletir sobre as intencionalidades das mat?rias que continham o desastre como manchete. Dessa forma, a oficina se apresenta como um importante mecanismo para que os alunos possam trabalhar as implica??es da pior trag?dia socioambiental ocorrida no Brasil.The present work presents the screening of the controversies that emerged from the development of a pedagogical workshop to produce journalistic texts, with a class in the final year of high school teaching. In this way, we use as theoretical-analytical support the principles of the Actor-Network Theory (TAR) to analyze circulations, flows and movements, from the translations among the actants, in the case of this work, students, teacher and newspapers. After the analyzes we observed that from the moments of discussions, debates and written production, many controversies emerged. We also emphasize that through the pedagogical workshop with newspapers, students were able to discuss the nuances of the disaster, as well as discuss and reflect on the intentionalities of the subjects that contained the disaster as a headline. In this way, the workshop presents itself as an important mechanism for students to work on the implications of the worst socio-environmental tragedy in Brazil

Genetic gains from selection for drought tolerance during three breeding periods in extra-early maturing maize hybrids under drought and rainfed environments

Open Access Journal; Published online: 23 Apr 2021Genetic gain studies in a breeding program are very important for measuring the efficiency of the program over a specific period. It also provides breeders with an understanding of the outcomes of the huge investments committed to the breeding programs. This study sought to (i) estimate the gains in grain yield under drought and rainfed conditions and (ii) identify high-yielding and stable hybrids developed in the last two decades under drought and rainfed conditions. Sixty extra-early maturing hybrids developed by the International Institute of Tropical Agriculture (IITA), Ibadan, during three breeding periods: (2008–2010, 2011–2013, and 2014–2016) were assessed under managed drought and rainfed conditions across 14 environments in Nigeria to estimate the genetic gains in grain yield using linear regression analysis. Considerably high genetic gains (4.1%) per year for grain yield was obtained for the extra-early maturing hybrids under drought environments. Six of the top ten hybrids identified were from period 3, an indication of the high genetic gains from selection in period 3. Additionally, two of the top six period 3 hybrids (TZEEI 29 × TZEEI 13) × TZEEI 64 and TZdEEI 64 × TZEEI 54 were found to be the best yielding and most stable across the 14 test environments and were highly recommended for extensive evaluations to warrant their commercialization in sub-Saharan Africa (SSA)