Approximation of a generalized Lipschitz class function by Euler - Cesàro means of Fourier series

In this paper, I have taken product of two summability methods, Euler and Cesaro; and establish a new theorem on the degree of approximation of the function f belonging to W(Lp, ?(t)) classes by Euler - Cesaro method. DOI: http://dx.doi.org/10.3126/bibechana.v9i0.7190 BIBECHANA 9 (2013) 151-15

Approximation of a generalized Lipschitz class function by Euler - Cesàro means of Fourier series

In this paper, I have taken product of two summability methods, Euler and Cesaro; and establish a new theorem on the degree of approximation of the function f belonging to W(Lp, ?(t)) classes by Euler - Cesaro method. DOI: http://dx.doi.org/10.3126/bibechana.v9i0.7190 BIBECHANA 9 (2013) 151-15

Effects of planting configuration and row spacing on growth and production of potato under mulched condition in Dadeldhura, Nepal

An experiment was conducted at the research site of Dadeldhura, Nepal in 2019 to identify optimum plant spacing for potato under mulched condition. Three levels of inter row spacing; 60 cm with single row per bed (1RB), 45 cm with double row per bed (2RB) and 30 cm with triple row per bed (3RB) and intra row spacing (20, 30 and 40 cm) were laid out in factorial randomized complete block design with three replications. Results showed that there was significant difference (p<0.05) for all parameters except on days to 50% germination, 90% flowering, 50% maturity and on main stem number and graded large sized tuber number and it's weight. Growth parameters namely canopy, leaf number and leaf area were significantly higher (p<0.05) in 60 cm (1RB) ×30 cm spacing. Plant height and leaf area index was significantly higher (p<0.05) in 60 cm (1RB) × 20 cm and 30(3RB) ×20 cm spacing respectively. Total number of tubers m-2 , weight of tubers  m-2, weight of marketable tubers m-2, harvest index, number of small sized tuber m-2 ,weight of small sized tubers m-2 and weight of medium sized tubers m-2 were found to be 56.24%,39.79%, 47.98%,4.41%,90.56%, 113.23% and 70.15% significantly higher (p<0.05)  in 30 cm (3RB) compared to 60 cm on (1RB) inter row spacing respectively and 59.72%, 61.15%, 58.30%, 4.41%, 114.90%, 137.31%, 55.39% higher in 20cm compared to 40 cm intra row spacing. Interaction effect was significant (p<0.05)  in marketable tuber number and medium sized tuber number in which the average highest number of marketable tubers (134.44) and medium sized tubers (121.08) was found in 30(3RB) ×20 cm spacing which was 165.95% and 235.03% significantly higher compared to  60×40 cm spacing respectively. So, this study showed that 30(3RB) ×20 cm spacing would be best spacing combination under mulched condition

Cost-benefit analysis and resource use efficiency of rice production system in different agriculture landscapes in Chitwan district, Nepal

The study was conducted to determine the cost-benefit analysis and resource use efficiency of the rice production system in different agriculture landscapes in the Chitwan district in 2018. The sample size of 102 rice-growing farmers out of 600 farmers, having an area of farm size greater than 0.5 hectares, was determined using Raosoft Inc. Software. A simple random sampling technique was used to collect 102 rice-growing household information in four municipalities (2 in plain and 2 in hilly area) using a semi-structured questionnaire. Data were analyzed using descriptive and statistical tools including Cobb-Douglas production function. Results showed that the use of inputs like seeds, chemical fertilizer and machinery like tractor were found significantly higher in the plain area whereas the use of inputs like labor, farmyard manure (FYM) and bullocks was found in higher in the hilly area. The costs of fertilizer, machinery, pesticide, and transportation were found higher in the plain area whereas the costs of seed, FYM, labor and bullocks were significantly higher in the hilly area. Production of rice per household was 1.87 ton whereas productivity was 5.2 ton/ha, gross profit was NRs. 41435and benefit-cost ratio was 1.59 in the plain area which was found significantly higher than the hilly area. The return to scale was found to be 0.48 which revealed that inputs used in rice production were ineffectively utilized in which organic fertilizer and labor resource were overused and seed, fertilizer, machinery and bullocks, pesticides and transportation were underused resources. The optimal allocation of these resources will increase the profitability of rice farming

Feminization of Agriculture in Nepal and its implications: Addressing Gender in Workload and Decision Making

The study assesses the two approaches of feminization: labor and managerial, and explores the implication of feminization in agricultural production in Gorkha and Chitwan district of Nepal. We examine the degree to which men, women or men and women jointly make agriculture-related decisions, and discuss the labor feminization and managerial feminization using five domains of the Women Empowerment in Agriculture Index (WEAI), relative to the degree to which women’s decision-making power relates to the feminization of agriculture leading to women empowerment and food security. The results revealed that the average workload for women (86.50 hours/week) was more than that for men (55.52 hours/week). Workload was found significantly affected by the total cultivated area (ha), gender of household head, occupation, number of livestock holdings, number of children, number of elders and household location.All aspects of operational and strategic decision making were dominated by jointly made decisions, except in the case of income utilization where female showed dominance. The implication of feminization in agriculture is reflected by reduction in cropping cycle, lower productivity of cereals and vegetables which led to food insecurity by own production. The income from remittance was observed to be mainly used for consumption purposes to ensure food security. It appears that the feminization of agriculture leads to women playing not only important role in decision-making but also more responsibilities and heavier workloads without necessarily resulting in empowerment and improvement in well-being

Yield Evaluation of Nutrient-rich Potato Clones in High Hill of Nepal

A study was conducted to evaluate the yield of nutrient-rich potato clones in high-hill districts: Dolakha and Jumla of Nepal during the years 2013 and 2014, respectively. Fourteen potato clones were tested as on-station and on-farm experiments at both districts, and those fourteen clones were compared to ‘Lady Rosita' and ‘Jumli Local' respectively as the check varieties in the first year experiment, 2013. Eight promising clones were selected from the first year experiment, and were evaluated and compared with same local varieties in the consecutive year, 2014. Two clones namely; CIP 395112.32 (19.3 tha-1) and CIP 393073.179 (17.8 tha-1) exhibited superior marketable tuber yield than that of ‘Lady Rosita'(14.2 tha-1) in Dolakha and five CIP clones namely; 395112.32 (25.5 tha-1), 393073.179 (22.5 tha-1), 394611.112 (20.9 tha-1), 390478.9 (19.9 tha-1) and 395017.229 (17.0 tha-1) showed higher marketable tuber yield than ‘Jumli Local'(14.5 tha-1). Based on two years' phenotypic and tuber yield result, clones CIP 395112.32 and CIP 393073.179 are recommended to potato growers at high hills of Nepal for commercial cultivation.Journal of Nepal Agricultural Research Council Vol.3 2017: 6-1

Clinician and administrator perspectives on outpatient administration of ciltacabtagene autoleucel in relapsed or refractory multiple myeloma

IntroductionChimeric antigen receptor (CAR) T-cell therapy (CAR T therapy) is a treatment option for patients with relapsed or refractory multiple myeloma that has led to unprecedented treatment outcomes. Among CAR T therapies available, ciltacabtagene autoleucel (cilta-cel) is a good candidate for outpatient administration due to its generally predictable safety profile. There are multiple advantages of outpatient administration of cilta-cel, including reduced healthcare burden, expanded access, and patient autonomy. This mixed methods qualitative study aimed to identify key factors for outpatient administration of CAR T and best practice recommendations by combining a targeted literature review with expert interviews and panels.MethodsThe targeted review (Phase 1) aimed to identify factors for outpatient CAR T administration in the US and determine key topics for the exploratory interviews (Phase 2) and expert panels (Phase 3), which aimed to inform on best practices and challenges of outpatient CAR T administration (focusing on cilta-cel). Participants in clinical and administrative positions based in treatment centers that had experience with real-world outpatient administration of cilta-cel were recruited.ResultsSeventeen studies were identified in Phase 1. Key factors for outpatient administration included the development of protocols for CAR T complications, education for caregivers, outpatient specialists, hospital staff, and emergency services staff for identification and referral after possible adverse events, the creation of multidisciplinary teams for effective communication and management, straightforward patient intake processes encompassing financial eligibility review and provision of patient education materials, and close patient monitoring throughout the treatment journey. In Phase 2, 5 participants from 2 centers were interviewed. In Phase 3, 14 participants across 6 treatment centers were interviewed. Two 90-minute virtual panel discussions took place. All participants agreed that cilta-cel can be safely and effectively administered in an outpatient setting. Key recommendations included the creation of educational resources for patients and caregivers, the development of standard operating procedures, dedicated outpatient infrastructure and establishment of interdisciplinary teams, outpatient monitoring for toxicity management, and monitoring of the reimbursement landscape.DiscussionThis study offers a comprehensive understanding of the feasibility of outpatient cilta-cel administration in participating CAR T centers and provides actionable recommendations while acknowledging existing challenges

Pemetrexed Induced Pneumonitis

Pemetrexed is an antifolate chemotherapy agent that is active in malignant mesothelioma and non-small cell lung cancer (NSCLC). Pneumonitis is a rare side effect of Pemetrexed. We report the case of 72-year-old female with metastatic poorly differentiated lung adenocarcinoma. She was placed on maintenance pemetrexed and developed gradual progressive dyspnea after first cycle of maintenance of pemextrexed. The computed tomography (CT) of the chest showed ground glass opacity in both lung fields. Transbronchial lung biopsy showed uniform interstitial widening by a cellular chronic infiltrate with areas of type II pneumocyte and exudation of pale eosinophilic edema fluid; features consistent with acute lung injury. Patient improved both clinically and radiological after stopping pemetrexed and starting prednisone. Although pemetrexed induced lung injury is relatively rare, with the increasing use of pemetrexed in first-line treatment and in maintenance therapy of non-small cell lung cancer, awareness of this potential adverse effects is important

BCMA-targeted CAR-T cell therapies in relapsed and/or refractory multiple myeloma: latest updates from 2023 ASCO Annual Meeting

Abstract Treatment of relapsed and/or refractory multiple myeloma (RRMM) utilizing the novel therapeutic target of the B-cell maturation antigen (BCMA) has demonstrated incredible results, leading to regulatory approval of BCMA-targeted chimeric antigen receptor (CAR)-T cell therapies in RRMM. With now two approved BCMA-targeted CAR-T cell therapies, investigators globally are working to build off and improve upon BCMA-targeted therapies. We discuss long-term data from the pivotal study that led to CAR-T approval, a phase 3 trial supporting their use in earlier lines, and novel manufacturing platforms to decrease vein-to-vein time. We highlight five key abstracts from the 2023 ASCO Annual Meeting that showcase these exciting updates in BCMA-directed CAR-T cell therapies in RRMM

Approximation of function belonging to Lipschitz class by . . .

In this paper, a new theorem on the degree of approximation of the function α ∈ lip f by lower triangular matrix summability method of Fourier series has been established