Integrated Modelling of Beach Water Table Fluctuations

Source: ICHE Conference Archive - https://mdi-de.baw.de/icheArchiv

3D layer-integrated modelling of morphodynamic processes near river regulated structures

Sedimentation and erosion can significantly affect the performance of river regulated reservoirs. In the vicinity of flow control structures, the interaction between the hydrodynamics and sediment transport often induces complex morphological processes. It is generally very challenging to accurately predict these morphological processes in real applications. Details are given of the refinement and application of a three-dimensional (3-D) layer integrated model to predict the morphological processes in a river regulated reservoir. The model employs an Alternating Direction Implicit finite difference algorithm to solve the mass, momentum and suspended sediment transport conservation equations, and an explicit finite difference scheme for the bed sediment mass conservation equation for calculating bed level changes. The model is verified against experimental data reported in the literature. It is then applied to a scaled physical model of a regulated reservoir, including the associated intakes and sluice gates, to predict the velocity distributions, sediment transport rates and bed level changes in the vicinity of the hydraulic structures. It is found that the velocity distribution near an intake is non-uniform, resulting in a reduction in the suspended sediment flux through the intake and the formation of a sedimentation zone inside the reservoir

Evaluation of E.coli losses in a tidal river network using a refined 1-D numerical model

Predicting the rate of Escherischia coli (E.coli) loss in a river network is one of the key conditions required in the management of bathing waters, with well verified numerical models being effective tools used to predict bathing water quality in regions with limited field data. In this study, a unique finite volume method (FVM) one-dimensional model is firstly developed to solve the mass transport process in river networks, with multiple moving stagnation points. The model is then applied to predict the concentration distribution of E.coli in the river Ribble network, UK, where the phenomena of multiple stagnation points and different flow directions appear extensively in a tidal sub-channel network. Validation of the model demonstrates that the proposed method gives reasonably accurate solution. The verification results show that the model predictions generally agree well with measured discharges, water levels and E.coli concentration values, with mass conservation of the solution reaching 99.0% within 12 days for the Ribble case. An analysis of 16 one-year scenario runs for the Ribble network shows that the main reduction in E.coli concentrations occurs in the riverine and estuarine regions due to the relatively large decay rate in the brackish riverine waters and the long retention time, due to the complex river discharge patterns and the tidal flows in the regions

A Cartesian Grid Method for Shallow Waterflows over a Gravel Bed

Source: ICHE Conference Archive - https://mdi-de.baw.de/icheArchiv

Effect of Endocrine Therapy Combined with Trastuzumab Targeted Therapy on Response Rate and Quality of Life in HER2-Positive Metastatic Breast Cancer

Objective: To analyze the effect of endocrine therapy combined with trastuzumab targeted therapy on HER2 (human epidermal growth factor receptor-2) positive metastatic breast cancer on the treatment efficiency and quality of life. Methods: Selected 100 patients with HER2-positive metastatic breast cancer who were treated in our hospital from January 2019 to December 2021, and divided them into a control group and an observation group according to the random number table method, with 50 cases in each group, and were given the clinical effects of single trastuzumab targeted therapy and endocrine therapy combined with trastuzumab targeted therapy were compared. Results: There was no significant difference in the incidence of adverse reactions between the two groups (P>0.05); the remission rate in the observation group was significantly higher than that in the control group (P<0.05); the overall health scale and function scale scores in the observation group were higher than those in the control group, and the individual items Measurement and symptom scale scores were lower than those in the control group (P < 0.05). Conclusion: Endocrine therapy combined with trastuzumab targeted therapy for HER2-positive metastatic breast cancer can effectively relieve the patient's condition and improve the patient's quality of life. The clinical effect is significant, and it is worthy of widespread application

Clinical Study of Endocrine Hormone Combined with Trastuzumab in Maintenance Treatment of HR and HER-2 Positive Advanced Breast Cancer

Objective: To analyze the clinical effect of endocrine hormone combined with trastuzumab in maintenance therapy of HR (hormone receptor) and HER-2 (human epidermal growth factor receptor) positive advanced breast cancer. Methods: A total of 80 patients with HR and HER-2 positive advanced breast cancer admitted to our hospital from January 2020 to December 2022 were selected, and the 80 patients were divided into 2 groups by random number table method, the control group (N= 40) The patients in the observation group (N=40) were treated with trastuzumab, and the patients in the observation group (N=40) were treated with endocrine hormones and trastuzumab for maintenance. The therapeutic effects of the two groups were compared. Results: The two groups of patients had similar serum CD8+, CD4+, CD3+ before treatment and CD8+ after treatment (P>0.05). After treatment, the CD4+ and CD3+ in the observation group were higher than those in the control group (P<0.05). The total effective rate of the observation group was significantly higher than that of the control group. It was higher in the control group (P<0.05); the incidence of adverse reactions in the observation group was lower than that in the control group (P<0.05). Conclusion: Endocrine hormone combined with trastuzumab maintenance therapy for HR and HER-2 positive advanced breast cancer has significant clinical effect, can effectively improve the immune indexes of patients, and has less adverse reactions, which is worthy of clinical application

Analysis of HER2 Gene Amplification and Certain Prognostic Factors in Breast Cancer

Objective: The HER2 gene amplification and certain prognostic factors in breast cancer were analyzed. Method: The gene amplification and protein expression of human epidermal growth factor receptor in 100 breast cancer tissues detected by FISH and IHC detection method in the hospital from January 2020 to December 2021 were analyzed. To analyze some breast cancer prognostic factors. Result: 0 is 8 cases of HER-2 protein breast cancer, (1+) is 11 cases, (2+) is 49 cases, (3+) is 32 cases. The HER2 gene was amplified in 49 cases, of which 23 cases showed red signals in clusters, and 26 cases showed red signals in dots. 51 cases of HER-2 gene were not amplified. There are differences in the detection results of FISH and IHC detection methods (P＞0.05). ER, PR and polysomy of chromosome 17 are prognostic factors associated with HER2 gene amplification in certain breast cancers. (P＜0.05) Conclusion: To analyze the HER2 gene amplification in breast cancer and targeted select FISH and IHC detection methods can improve the therapeutic effect and prognostic factor, which deserves clinical attention