A Kinematically Unbiased Search for Nearby Young Stars in the Northern Hemisphere Selected Using SuperWASP Rotation Periods

We present a kinematically-unbiased search to identify young, nearby low-mass members of kinematic moving groups (MGs). Objects with both rotation periods shorter than 5 days in the SuperWASP All-Sky Survey and X-ray counterparts in the ROSAT All-Sky Survey were chosen to create a catalog of several thousand rapidly-rotating, X-ray active FGK stars. These objects are expected to be either young single stars or tidally-locked spectroscopic binaries. We obtained optical spectra for a sub-sample of 146 stars to determine their ages and kinematics, and in some cases repeat radial velocity (RV) measurements were used to identify binarity. Twenty-six stars are found to have lithium abundances consistent with an age of <=200 Myr, and show no evidence for binarity and in most cases measurements of H-alpha and v\sin i support their youthful status. Based on their youth, their radial velocities and estimates of their 3-dimensional kinematics, we find 11 objects that may be members of known MGs, 8 that do not appear associated with any young MG and a further 7 that are close to the kinematics of the recently proposed "Octans-Near" MG, and which may be the first members of this MG found in the northern hemisphere. The initial search mechanism was ~18 per cent efficient at identifying likely-single stars younger than 200 Myr, of which 80 per cent were early-K spectral types

Searching for new young stars in the northern hemisphere: The Pisces Moving Group

Using the kinematically unbiased technique described in Binks, Jeffries & Maxted (2015), we present optical spectra for a further 122 rapidly-rotating (rotation periods <6 days), X-ray active FGK stars, selected from the SuperWASP survey. We identify 17 new examples of young, probably single stars with ages of <200 Myr and provide additional evidence for a new northern hemisphere kinematic association: the Pisces Moving Group (MG). The group consists of 14 lithium-rich G- and K-type stars, that have a dispersion of only ∼3 km s−1 in each Galactic space velocity coordinate. The group members are approximately co-eval in the colour-magnitude diagram, with an age of 30–50 Myr, and have similar, though not identical, kinematics to the Octans-Near MG. stars: low-mass, stars: pre-main-sequenc

A kinematically hot population of young stars in the solar neighbourhood

In the last three decades several hundred nearby members of young stellar moving groups (MGs) have been identified, but there has been less systematic effort to quantify or characterise young stars that do not belong to previously identified MGs. Using a kinematically unbiased sample of 225 lithium-rich stars within 100 pc, we find that only $50 \pm 10$ per cent of young ($\lesssim 125$ Myr), low-mass ($0.5<M/M_{\odot}<1.0$) stars, are kinematically associated with known MGs. Whilst we find some evidence that six of the non-MG stars may be connected with the Lower Centaurus-Crux association, the rest form a kinematically "hotter" population, much more broadly dispersed in velocity, and with no obvious concentrations in space. The mass distributions of the MG members and non-MG stars is similar, but the non-MG stars may be older on average. We briefly discuss several explanations for the origin of the non-MG population

A WISE-based search for debris discs amongst M-dwarfs in nearby, young, moving groups

We present a search for debris discs amongst M-dwarf members of nearby, young (5–150 Myr) moving groups (MGs) using infrared (IR) photometry, primarily from the Wide Infrared Survey Explorer (WISE). A catalogue of 100 MG M dwarfs that have suitable WISE data is compiled, and 19 of these are found to have significant IR excess emission at 22 μm. Our search is likely to be complete for discs where the ratio of flux from the disc to flux from the star fd/f* > 10−3. The spectral energy distributions are supplemented with Two-Micron All-Sky Survey (2MASS) photometry and data at longer wavelengths, and fitted with simple disc models to characterize the IR excesses. There is a bimodal distribution – 12 targets have W1 − W4 > 3, corresponding to fd/f* > 0.02, and are likely to be gas-rich, primordial discs. The remaining seven targets have W1 − W4 < 1 (fd/f* ≲ 10−3) and include three objects with previously known or suspected debris discs and four new debris disc candidates that are all members of the Beta Pic MG. All of the IR excesses are identified in stars that are likely members of MGs with age <30 Myr. The detected debris disc frequency falls from 13 ± 5 per cent to <7 per cent (at 95 per cent confidence) for objects younger or older than 30 Myr, respectively. This provides evidence for the evolution of debris discs on this time-scale and does not support models where the maximum of debris disc emission occurs much later in lower mass stars

A kinematically unbiased, all-sky search for nearby, young, low-mass stars

The past two decades have seen dramatic progress in our knowledge of the population of young stars of age $< 200\,$Myr that lie within $150\,$pc of the Sun. These nearby, young stars, most of which are found in loose, comoving groups, provide the opportunity to explore (among many other things) the dissolution of stellar clusters and their diffusion into the field star population. Here, we exploit the combination of astrometric and photometric data from {\it Gaia} and photometric data from GALEX (UV) and 2MASS (near-IR) in an attempt to identify additional nearby, young, late-type stars. Specifically, we present a sample of 146 GALEX UV-selected late-type (predominantly K-type) field stars with {\it Gaia}-based distances $< 125\,$pc (based on {\it Gaia} Data Release 1) that have isochronal ages $< 80\,$Myr even if equal-components binaries. We investigate the spectroscopic and kinematic properties of this sample. Despite their young isochronal ages, only $\sim 10$ per cent) of stars among this sample can be confidently associated with established nearby, young moving groups (MGs). These candidate MG members include 5 stars newly identified in this study. The vast majority of our sample of 146 nearby young star candidates have anomalous kinematics relative to the known MGs. These stars may hence represent a previously unrecognised population of young stars that has recently mixed into the older field star population. We discuss the implications and caveats of such a hypothesis---including the intriguing fact that, in addition to their non-young-star-like kinematics, the majority of the UV-selected, isochronally young field stars within $50\,$pc appear surprisingly X-ray faint

SPPS: A Sequence-Based Method for Predicting Probability of Protein-Protein Interaction Partners

Background: The molecular network sustained by different types of interactions among proteins is widely manifested as the fundamental driving force of cellular operations. Many biological functions are determined by the crosstalk between proteins rather than by the characteristics of their individual components. Thus, the searches for protein partners in global networks are imperative when attempting to address the principles of biology. Results: We have developed a web-based tool ‘‘Sequence-based Protein Partners Search’ ’ (SPPS) to explore interacting partners of proteins, by searching over a large repertoire of proteins across many species. SPPS provides a database containing more than 60,000 protein sequences with annotations and a protein-partner search engine in two modes (Single Query and Multiple Query). Two interacting proteins of human FBXO6 protein have been found using the service in the study. In addition, users can refine potential protein partner hits by using annotations and possible interactive network in the SPPS web server. Conclusions: SPPS provides a new type of tool to facilitate the identification of direct or indirect protein partners which may guide scientists on the investigation of new signaling pathways. The SPPS server is available to the public a

Immunological Responses and Actin Dynamics in Macrophages Are Controlled by N-Cofilin but Are Independent from ADF

Dynamic changes in the actin cytoskeleton are essential for immune cell function and a number of immune deficiencies have been linked to mutations, which disturb the actin cytoskeleton. In macrophages and dendritic cells, actin remodelling is critical for motility, phagocytosis and antigen presentation, however the actin binding proteins, which control antigen presentation have been poorly characterized. Here we dissect the specific roles of the family of ADF/cofilin F-actin depolymerizing factors in macrophages and in local immune responses

Panel 4 : Report of the Microbiology Panel

Objective. To perform a comprehensive review of the literature from July 2011 until June 2015 on the virology and bacteriology of otitis media in children. Data Sources. PubMed database of the National Library of Medicine. Review Methods. Two subpanels comprising experts in the virology and bacteriology of otitis media were created. Each panel reviewed the relevant literature in the fields of virology and bacteriology and generated draft reviews. These initial reviews were distributed to all panel members prior to meeting together at the Post-symposium Research Conference of the 18th International Symposium on Recent Advances in Otitis Media, National Harbor, Maryland, in June 2015. A final draft was created, circulated, and approved by all panel members. Conclusions. Excellent progress has been made in the past 4 years in advancing our understanding of the microbiology of otitis media. Numerous advances were made in basic laboratory studies, in animal models of otitis media, in better understanding the epidemiology of disease, and in clinical practice. Implications for Practice. (1) Many viruses cause acute otitis media without bacterial coinfection, and such cases do not require antibiotic treatment. (2) When respiratory syncytial virus, metapneumovirus, and influenza virus peak in the community, practitioners can expect to see an increase in clinical otitis media cases. (3) Biomarkers that predict which children with upper respiratory tract infections will develop otitis media may be available in the future. (4) Compounds that target newly identified bacterial virulence determinants may be available as future treatment options for children with otitis media.Peer reviewe

The Gaia-ESO Public Spectroscopic Survey: Motivation, implementation, GIRAFFE data processing, analysis, and final data products

The Gaia-ESO Public Spectroscopic Survey is an ambitious project designed to obtain astrophysical parameters and elemental abundances for 100,000 stars, including large representative samples of the stellar populations in the Galaxy, and a well-defined sample of 60 (plus 20 archive) open clusters. We provide internally consistent results calibrated on benchmark stars and star clusters, extending across a very wide range of abundances and ages. This provides a legacy data set of intrinsic value, and equally a large wide-ranging dataset that is of value for homogenisation of other and future stellar surveys and Gaia's astrophysical parameters. This article provides an overview of the survey methodology, the scientific aims, and the implementation, including a description of the data processing for the GIRAFFE spectra. A companion paper (arXiv:2206.02901) introduces the survey results. Gaia-ESO aspires to quantify both random and systematic contributions to measurement uncertainties. Thus all available spectroscopic analysis techniques are utilised, each spectrum being analysed by up to several different analysis pipelines, with considerable effort being made to homogenise and calibrate the resulting parameters. We describe here the sequence of activities up to delivery of processed data products to the ESO Science Archive Facility for open use. The Gaia-ESO Survey obtained 202,000 spectra of 115,000 stars using 340 allocated VLT nights between December 2011 and January 2018 from GIRAFFE and UVES. The full consistently reduced final data set of spectra was released through the ESO Science Archive Facility in late 2020, with the full astrophysical parameters sets following in 2022