Yang-Mills Magneto-Fluid Unification

We generalize the hybrid magneto-fluid model of a charged fluid interacting with an electromagnetic field to the dynamics of a relativistic hot fluid interacting with a non-Abelian field. The fluid itself is endowed with a non-Abelian charge and the consequences of this generalization are worked out. Applications of this formalism to the Quark Gluon Plasma are suggested.Comment: 6 pages, RevTex

Combining genome-wide association mapping and transcriptional networks to identify novel genes controlling glucosinolates in Arabidopsis thaliana.

BackgroundGenome-wide association (GWA) is gaining popularity as a means to study the architecture of complex quantitative traits, partially due to the improvement of high-throughput low-cost genotyping and phenotyping technologies. Glucosinolate (GSL) secondary metabolites within Arabidopsis spp. can serve as a model system to understand the genomic architecture of adaptive quantitative traits. GSL are key anti-herbivory defenses that impart adaptive advantages within field trials. While little is known about how variation in the external or internal environment of an organism may influence the efficiency of GWA, GSL variation is known to be highly dependent upon the external stresses and developmental processes of the plant lending it to be an excellent model for studying conditional GWA.Methodology/principal findingsTo understand how development and environment can influence GWA, we conducted a study using 96 Arabidopsis thaliana accessions, >40 GSL phenotypes across three conditions (one developmental comparison and one environmental comparison) and ∼230,000 SNPs. Developmental stage had dramatic effects on the outcome of GWA, with each stage identifying different loci associated with GSL traits. Further, while the molecular bases of numerous quantitative trait loci (QTL) controlling GSL traits have been identified, there is currently no estimate of how many additional genes may control natural variation in these traits. We developed a novel co-expression network approach to prioritize the thousands of GWA candidates and successfully validated a large number of these genes as influencing GSL accumulation within A. thaliana using single gene isogenic lines.Conclusions/significanceTogether, these results suggest that complex traits imparting environmentally contingent adaptive advantages are likely influenced by up to thousands of loci that are sensitive to fluctuations in the environment or developmental state of the organism. Additionally, while GWA is highly conditional upon genetics, the use of additional genomic information can rapidly identify causal loci en masse

Coastal sand dune and its importance in near shore marine ecosystem

The coastal region along with sandy dunes, have been used by man for different activities. The dunes have been utilized without understanding the dangerous effects, their disappearance can cause to the surrounding environment. Indiscriminate cutting of coastal vegetation and over–exploitation of beach sand for developmental works have resulted in erosion of vast coastal area. Sand dunes are very important systems which require careful planning and management

Stress-Mediated cis-Element Transcription Factor Interactions Interconnecting Primary and Specialized Metabolism in planta

Plant specialized metabolites are being used worldwide as therapeutic agents against several diseases. Since the precursors for specialized metabolites come through primary metabolism, extensive investigations have been carried out to understand the detailed connection between primary and specialized metabolism at various levels. Stress regulates the expression of primary and specialized metabolism genes at the transcriptional level via transcription factors binding to specific cis-elements. The presence of varied cis-element signatures upstream to different stress-responsive genes and their transcription factor binding patterns provide a prospective molecular link among diverse metabolic pathways. The pattern of occurrence of these cis-elements (overrepresentation/common) decipher the mechanism of stress-responsive upregulation of downstream genes, simultaneously forming a molecular bridge between primary and specialized metabolisms. Though many studies have been conducted on the transcriptional regulation of stress-mediated primary or specialized metabolism genes, but not much data is available with regard to cis-element signatures and transcription factors that simultaneously modulate both pathway genes. Hence, our major focus would be to present a comprehensive analysis of the stress-mediated interconnection between primary and specialized metabolism genes via the interaction between different transcription factors and their corresponding cis-elements. In future, this study could be further utilized for the overexpression of the specific transcription factors that upregulate both primary and specialized metabolism, thereby simultaneously improving the yield and therapeutic content of plants

LIPID PEROXIDE LEVELS AND ANTIOXIDANT STATUS IN HEALTHY AND ALCOHOLIC HEPATITIS PATIENTS

Background: Alcohol remains the single most significant cause of liver disease throughout the Western world, responsible for between 40 and 80% of cases of cirrhosis in different countries. Material & Methods:The study was conducted in Department of Biochemistry, Santosh medical college & Hospital, Ghaziabad and Veer Chandra Singh Garhwali Govt. Institute of Medical Sciences & Research, 164 alcoholic hepatitis patients were subjected to detailed clinical examination and laboratory investigations and the results were compared with 82controls. Blood samples were collected for oxidative stress parameters. It was observed that there was a significant increase in activities of Catalase, SOD, MDA, GPX and GR activity in patients with alcoholic hepatitis when compared to controls. Results: Results of our study show higher oxygen free radical production, evidenced by elevated levels of MDA and decreased levels of Catalase, SOD, GPx, GR, and TAS activity, supporting the evidence of oxidative stress in alcoholic hepatitis patients. Decreased concentrations of antioxidant support the hypothesis that alcoholic hepatitis is an important causative factor in pathogenesis of lipid peroxidation. Conclusion: Theantioxidant defense mechanisms might be impaired in patients with alcoholic hepatitis. These findings also provide a theoretical basis for development of novel therapeutic strategies, such as antioxidant supplementation. Keywords: Alcoholic Hepatitis; Catalase; Glutathione Peroxidase; Glutathione Reductase; Malondialdehyde; Superoxide dismutase; Total antioxidant status

LIPID PEROXIDE LEVELS AND ANTIOXIDANT STATUS IN HEALTHY AND ALCOHOLIC HEPATITIS PATIENTS

Background: Alcohol remains the single most significant cause of liver disease throughout the Western world, responsible for between 40 and 80% of cases of cirrhosis in different countries. Material & Methods:The study was conducted in Department of Biochemistry, Santosh medical college & Hospital, Ghaziabad and Veer Chandra Singh Garhwali Govt. Institute of Medical Sciences & Research, 164 alcoholic hepatitis patients were subjected to detailed clinical examination and laboratory investigations and the results were compared with 82controls. Blood samples were collected for oxidative stress parameters. It was observed that there was a significant increase in activities of Catalase, SOD, MDA, GPX and GR activity in patients with alcoholic hepatitis when compared to controls. Results: Results of our study show higher oxygen free radical production, evidenced by elevated levels of MDA and decreased levels of Catalase, SOD, GPx, GR, and TAS activity, supporting the evidence of oxidative stress in alcoholic hepatitis patients. Decreased concentrations of antioxidant support the hypothesis that alcoholic hepatitis is an important causative factor in pathogenesis of lipid peroxidation. Conclusion: Theantioxidant defense mechanisms might be impaired in patients with alcoholic hepatitis. These findings also provide a theoretical basis for development of novel therapeutic strategies, such as antioxidant supplementation. Keywords: Alcoholic Hepatitis; Catalase; Glutathione Peroxidase; Glutathione Reductase; Malondialdehyde; Superoxide dismutase; Total antioxidant status

Prevalence of fatty liver disease in children with obesity- a diagnostic study based on its ultrasound appearance

Background: Non-alcoholic fatty liver disease is an asymptomatic involvement of the liver, can progress to chronic liver disease and must be identified at an early stage for good prognosis. The implementation of the appropriate therapeutic interventions is determinant of the attempts to treat it. For that purpose, early diagnosis and staging of the disease is essential. It seems that diagnostic imaging should be a first-line tool for the staging and monitoring pediatric NAFLD/NASH for appropriate interventions to be implanted in a timely way. This study evaluated the prevalence of fatty liver in relation with body mass index (BMI) by means of ultrasound in children of age group 6-15 years.Methods: In this cross-sectional study, 83 children aged 6 to 15 years, were selected randomly. The participants were examined by a pediatrician. Liver ultrasound was performed for all children and grade of fatty liver was determined.Results: There was a significant correlation between grade of fatty liver with BMI, our study showed a strong association between BMI and prevalence of fatty liver on ultrasound.Conclusions: According to the study hypothesis, based on BMI, the degree of NAFLD in children were predictable. Ultrasound of liver in grading of fatty liver is one of the assessments methods of fatty liver but it is not a diagnostic method; it is useful for prevention to reduce BMI

Singularity Structure, Symmetries and Integrability of Generalized Fisher Type Nonlinear Diffusion Equation

In this letter, the integrability aspects of a generalized Fisher type equation with modified diffusion in (1+1) and (2+1) dimensions are studied by carrying out a singularity structure and symmetry analysis. It is shown that the Painlev\'e property exists only for a special choice of the parameter ($m=2$). A B\"acklund transformation is shown to give rise to the linearizing transformation to the linear heat equation for this case ($m=2$). A Lie symmetry analysis also picks out the same case ($m=2$) as the only system among this class as having nontrivial infinite dimensional Lie algebra of symmetries and that the similarity variables and similarity reductions lead in a natural way to the linearizing transformation and physically important classes of solutions (including known ones in the literature), thereby giving a group theoretical understanding of the system. For nonintegrable cases in (2+1) dimensions, associated Lie symmetries and similarity reductions are indicated.Comment: 8 page