N-[2-(2-Chloro­phen­yl)-2-hy­droxy­eth­yl]propan-2-aminium benzoate

In the title compound, C11H17ClNO+·C7H5O2 −, obtained by the reaction of chlorprenaline {or 1-(2-chlorophenyl)-2-[(1-methylethyl)amino]ethanol} and benzoic acid, the chlorprenaline is twisted moderately [C—C—C—C torsion angle = −76.00 (17)°] compared with related compounds. The mol­ecules as usual form dimers. In the crystal structure, the two components are connected by classical O—H⋯O and N—H⋯O hydrogen bonds

Unifying Two-Stream Encoders with Transformers for Cross-Modal Retrieval

Most existing cross-modal retrieval methods employ two-stream encoders with different architectures for images and texts, \textit{e.g.}, CNN for images and RNN/Transformer for texts. Such discrepancy in architectures may induce different semantic distribution spaces and limit the interactions between images and texts, and further result in inferior alignment between images and texts. To fill this research gap, inspired by recent advances of Transformers in vision tasks, we propose to unify the encoder architectures with Transformers for both modalities. Specifically, we design a cross-modal retrieval framework purely based on two-stream Transformers, dubbed \textbf{Hierarchical Alignment Transformers (HAT)}, which consists of an image Transformer, a text Transformer, and a hierarchical alignment module. With such identical architectures, the encoders could produce representations with more similar characteristics for images and texts, and make the interactions and alignments between them much easier. Besides, to leverage the rich semantics, we devise a hierarchical alignment scheme to explore multi-level correspondences of different layers between images and texts. To evaluate the effectiveness of the proposed HAT, we conduct extensive experiments on two benchmark datasets, MSCOCO and Flickr30K. Experimental results demonstrate that HAT outperforms SOTA baselines by a large margin. Specifically, on two key tasks, \textit{i.e.}, image-to-text and text-to-image retrieval, HAT achieves 7.6\% and 16.7\% relative score improvement of Recall@1 on MSCOCO, and 4.4\% and 11.6\% on Flickr30k respectively. The code is available at \url{https://github.com/LuminosityX/HAT}.Comment: Accepted at ACM Multimedia 202

Orthokeratology lens and conventional frame glasses for ocular parameters of myopia adolescent

AIM: To explore the effects of overnight orthokeratology lens and conventional frame glasses on the myopic diopter, uncorrected visual acuity and ocular parameters of myopia adolescent. METHODS: Totally 102 cases of(204 eyes)of adolescent myopia patients were randomly divided into observation group and control group with 51 cases(102 eyes)in each group during April 2014 to April 2017. Control group was only given conventional frame glasses, and observation group was given overnight orthokeratology lens. The myopic diopter and uncorrected visual acuity(UCVA)before wearing glasses and at 1wk, 1, 3, 6mo and 1a of wearing glasses, and the ocular parameters before wearing glasses and at 1a after wearing glasses were observed in the two groups, and the occurrence of complications was compared between the two groups. RESULTS: After 1wk to 1a of wearing glasses, the myopic diopter in observation group was gradually decreased(PP>0.05), but there was statistically significant difference between-groups at different time points(PPPP>0.05), and the axial length in control group was significantly longer than that before wearing glasses and that in observation group(PP>0.05).CONCLUSION: Overnight orthokeratology lens for adolescent myopia can effectively correct the myopic diopter, and improve the uncorrected visual acuity. It is less harmful to the eyes and less complications, and it is safe and reliable in clinical application

N-[2-(2-Chloro­phen­yl)-2-hydroxy­ethyl]propan-2-aminium nitrate

In the title compound, C11H17ClNO+·NO3 −, the side chain of the ethyl­ammonium group is orientated approximately perpendicular to the benzene ring, the dihedral angle between the C/C/N plane of the ethyl­ammonium group and the benzene ring being 79.40 (18)°. In the crystal structure, inter­molecular O—H⋯O and N—H⋯O hydrogen bonds are observed between the cation and the anion

Novel Microfiber Sensor and Its Biosensing Application for Detection of hCG Based on a Singlemode-Tapered Hollow Core-Singlemode Fiber Structure

A novel microfiber sensor is proposed and demonstrated based on a singlemode-tapered hollow core -singlemode (STHS) fiber structure. Experimentally a STHS with taper waist diameter of 26.5 μm has been fabricated and RI sensitivity of 816, 1601.86, and 4775.5 nm/RIU has been achieved with RI ranges from 1.3335 to 1.3395 , from 1.369 to 1.378, and from 1.409 to 1.4175 respectively, which agrees very well with simulated RI sensitivity of 885, 1517, and 4540 nm/RIU at RI ranges from 1.3335 to 1.337, from 1.37 to 1.374, and from 1.41 to 1.414 . The taper waist diameter has impact on both temperature and strain sensitivity of the sensor structure: (1) the smaller the waist diameter, the higher the temperature sensitivity, and experimentally 26.82 pm/°C has been achieved with a taper waist diameter of 21.4 μm; (2) as waist diameter decrease, strain sensitivity increase and 7.62 pm/με has been achieved with a taper diameter of 20.3 μm. The developed sensor was then functionalized for human chorionic gonadotropin (hCG) detection as an example for biosensing application. Experimentally for hCG concentration of 5 mIU/ml, the sensor has 0.5 nm wavelength shift, equivalent to limit of detection (LOD) of 0.6 mIU/ml by defining 3 times of the wavelength variation (0.06 nm) as measurement limit. The biosensor demonstrated relatively good reproducibility and specificity, which has potential for real medical diagnostics and other applications

Network pharmacology-based elucidation of the molecular mechanism underlying the anti-migraine effect of Asari Radix et Rhizoma

Purpose: To determine the molecular mechanism involved in the anti-migraine effect of Asari Radix et Rhizoma (ARR) using network pharmacology. Methods: The compounds present in ARR were identified through information retrieval from literature and public databases, and were screened based on absorption, distribution, metabolism, excretion and toxicity. Target genes related to the selected compounds and migraine were identified or predicted from public databases. Hub genes in ARR against migraine were identified through analysis of interactions in overlapping genes between compounds and migraine target genes, based on STRING database. Gene enrichment analysis of overlapping genes was performed using Database for Annotation, Visualization and Integrated Discovery. Results: A total of 138 compounds were selected as potential bioactive compounds in ARR. Target genes related to the selected compounds (611 genes) and migraine (278 genes) were obtained, including 71 overlapping genes. The hub genes in the anti-migraine effect of ARR were BDNF, IL6, COMT, APP and TNF. Gene enrichment analysis showed the top 10 biological processes or pathways involved in the mechanism of anti-migraine action of ARR. The tissue source of the overlapping genes was not limited to the brain. The results from gene enrichment analysis revealed that the effect of ARR on migraine was holistic, which is characteristic of traditional Chinese medicines. Conclusion: Network pharmacology has been used to decipher the molecular mechanism involved in the action of ARR against migraine. The results provide a scientific basis for the clinical effect of ARR on migraine