Absurdity underneath realistic elements in Pinter’s The Dumb Waiter

This paper is a study on the absurdity underneath the realistic factors in Harold Pinter’s The Dumb Waiter. Through analyzing the realistic elements in The Dumb Waiter’s setting, plot and characterization respectively, this paper attempts to prove that despite these realistic aspects, the overall effect of the play is one of uncertainty and absurdity. Key words: The Dumb Waiter, realism, absurdity Résumé: L’article présent étudie principalement l’utilisation des éléments réalistes et l’absurdité cachée sous l’apparence réaliste dans la pièce d’Harold Pinter- Le Serveur muet. A travers l’interprétation de cette pièce, l’auteur croit que, malgré l’utilisation du système du théâtre réaliste traditionnel dans l’agencement du contexte, la structure de l’intrigue et la description des personnages, cette pièce exprime, du point de vue plus profond, l’absurdité de la condition humaine ainsi que l’isolement et la solitude entre les êtres. Mots-Clés: Le Serveur muet, réalisme, absurdit

Scale Invariant Power Spectrum in Ho\v{r}ava-Lifshitz Cosmology without Matter

In this paper we investigate the physical implications of the dynamical scalar mode in pure Horava-Lifshitz gravity on cosmology. We find that it can produce a scale-invariant power spectrum in UV era if the detailed balance condition on the action is relaxed. This indicates that the physical scalar mode may seed the large scale structure and Horava-Lifshitz cosmology could be a qualified alternative to inflationary scenario.Comment: 10 pages; References added; More clarifications, published versio

Experimental Demonstration of High-Rate Discrete-Modulated Continuous-Variable Quantum Key Distribution System

A high-rate continuous-variable quantum key distribution (CV-QKD) system based on high-order discrete modulation is experimentally investigated. With the help of the novel system scheme, effective digital signal processing algorithms and advanced analytical security proof method, the transmission results of 5 km, 10 km, 25 km, and 50 km are achieved for the 1 GBaud optimized quantum signals. Correspondingly, the asymptotic secret key rate (SKR) is 288.421 Mbps, 159.395 Mbps, 50.004 Mbps and 7.579 Mbps for discrete Gaussian (DG) 64QAM, and 326.708 Mbps, 179.348 Mbps, 50.623 Mbps and 9.212 Mbps for DG 256QAM. Under the same parameters, the achieved SKRs of DG 256QAM is almost same to ideal Gaussian modulation. In this case, the demonstrated high-rate discrete modulated CV-QKD system has the application potential for high speed security communication under tens of kilometers.Comment: 5 pages, 5 figure

Effects of capsaicin on the cholesterol lithogenesis in the gallbladder of C57BL/6 mice

_Objective:_ High-fat diet was used to induce cholesterol lithogenesis in the gallbladder of C57BL/6 mice in which the effects of capsaicin on the cholesterol lithogenesis were investigated and the potential mechanism was explored. _Methods:_ A total of 30 C57BL/6 mice were randomly didivded intocontrol group (mice were feed with normal food), gallbladder stone group (GS group; mice received high fat diet) and capsaicin group (CA group; mice received high fat diet containing 0.015% capsaicin). _Results:_ Results showed 0%, 100% and 20% of mice had gallbladder stone in control group, GS group and CA group, respectively. All the parameters became abnormal in GS group as compared to control group, but improved to different extents after simultaneous intake of capsaicin (such as total cholesterol in bile acid, and total cholesterol, triglycerides, low-density lipoprotein and high-density lipoprotein in the serum). In GS group, cholesterol saturated index (CSI) increased significantly (1.32 vs. 0.46) as compared to control group suggesting the cholesterol supersaturated bile. The CSI was reduced to 0.8 in CA group. In addition, simultaneous intake of capsaicin significantly improved the abnormal expressions of COX-2, MUC5AC and TRPV1 in the gallbladder and abnormal expressions of CYP7A1, HMG-CoA r

Spectrum-effect relationships between high performance liquid chromatography fingerprint and analgesic property of Anisodus tanguticus (Maxim) Pascher (Solanaceae) roots

Purpose: To investigate the spectrum-effect relationships between high performance liquid chromatography with photodiode array detection (HPLC-DAD) fingerprint and analgesic activity of Anisodus tanguticus (Maxim.) Pascher (Solanaceae) (AT)  roots.Methods: Analgesic activity of AT roots was evaluated by acetic acid-induced writhing test in mice. Fingerprint of AT roots was established by HPLC-DAD. After oral administration of AT roots extract, intra-gastric contents of caffeoylputrescine, anisodine, fabiatrin, scopolin, scopolamine, anisodamine and atropine in mice were determined by HPLC-DAD. Spectrum-effect relationships between HPLCDAD fingerprint and analgesic activity were investigated using bivariate correlation analysis.Results: Following treatment with different batches of AT roots extract, acetic acid-induced writhing responses in mice were inhibited significantly (p < 0.05 or 0.01), with inhibitions of 26.62 - 55.13 %, relative to the control group. Sixteen common peaks were obtained by fingerprint analysis. Peaks 1, 2, 6, 7, 8, 9 and 12 were identified as caffeoylputrescine, anisodine, fabiatrin, scopolin, scopolamine, anisodamine and atropine, respectively. Bivariate correlation analysis between analgesic activity of AT roots and 16 common peaks areas indicated the  contributions of 16 common peaks to analgesic activity of AT roots. Surprisingly, bivariate correlation analysis between analgesic activity of AT roots and intragastric contents of above-named 7 constituents revealed that the contributions of the 7 constituents to analgesic activity of AT roots were different from those based on their peak areas.Conclusion: This study provides scientific justification for the investigation of the active constituents of AT root with a view to its standardization.Keywords: Anisodus tanguticus root, Analgesic activity, HPLC-DAD fingerprint,  Bivariate correlation analysi

Melatonin Prevents Osteoarthritis-Induced Cartilage Degradation via Targeting MicroRNA-140

Abstract Osteoarthritis (OA) is characterized by the progressive destruction of articular cartilage, which is involved in the imbalance between extracellular matrix (ECM) synthesis and degradation. MicroRNA-140-5p (miR-140) is specifically expressed in cartilage and plays an important role in OA-induced matrix degradation. The aim of this study was to investigate (1) whether intra-articular injection of melatonin could ameliorate surgically induced OA in mice and (2) whether melatonin could regulate matrix-degrading enzymes at the posttranscriptional level by targeting miR-140. In an in vitro OA environment induced by interleukin-1 beta (IL-1β), melatonin treatment improved cell proliferation of human chondrocytes, promoted the expression of cartilage ECM proteins (e.g., type II collagen and aggrecan), and inhibited the levels of IL-1β-induced proteinases, such as matrix metalloproteinase 9 (MMP9), MMP13, ADAMTS4 (a disintegrin and metalloproteinase with thrombospondin motifs 4), and ADAMTS5. Both the microarray and polymerase chain reaction (PCR) experiments revealed that miR-140 was a melatonin-responsive microRNA and melatonin upregulated miR-140 expression, which was suppressed by IL-1β stimulation. In vivo experiments demonstrated that intra-articular injection of melatonin prevented disruptions of cartilage matrix homeostasis and successfully alleviated the progression of surgery-induced OA in mice. Transfection of miR-140 antagomir completely counteracted the antiarthritic effects of melatonin by promoting matrix destruction. Our findings demonstrate that melatonin protects the articular cartilage from OA-induced degradation by targeting miR-140, and intra-articular administration of melatonin may benefit patients suffering from OA

Deubiquitinating Enzymes Orchestrate the Cancer Stem Cell-Immunosuppressive Niche Dialogue: New Perspectives and Therapeutic Potential

Cancer stem cells (CSCs) are sparks for igniting tumor recurrence and the instigators of low response to immunotherapy and drug resistance. As one of the important components of tumor microenvironment, the tumor associated immune microenvironment (TAIM) is driving force for the heterogeneity, plasticity and evolution of CSCs. CSCs create the inhibitory TAIM (ITAIM) mainly through four stemness-related signals (SRSs), including Notch-nuclear factor-κB axis, Hedgehog, Wnt and signal transducer and activator of transcription. Ubiquitination and deubiquitination in proteins related to the specific stemness of the CSCs have a profound impact on the regulation of ITAIM. In regulating the balance between ubiquitination and deubiquitination, it is crucial for deubiquitinating enzymes (DUBs) to cleave ubiquitin chains from substrates. Ubiquitin-specific peptidases (USPs) comprise the largest family of DUBs. Growing evidence suggests that they play novel functions in contribution of ITAIM, including regulating tumor immunogenicity, activating stem cell factors, upregulating the SRSs, stabilizing anti-inflammatory receptors, and regulating anti-inflammatory cytokines. These overactive or abnormal signaling may dampen antitumor immune responses. The inhibition of USPs could play a regulatory role in SRSs and reversing ITAIM, and also have great potential in improving immune killing ability against tumor cells, including CSCs. In this review, we focus on the USPs involved in CSCs signaling pathways and regulating ITAIM, which are promising therapeutic targets in antitumor therapy

Manipulating Multiple Order Parameters via Oxygen Vacancies: The case of Eu0.5Ba0.5TiO3-{\delta}

Controlling functionalities, such as magnetism or ferroelectricity, by means of oxygen vacancies (VO) is a key issue for the future development of transition metal oxides. Progress in this field is currently addressed through VO variations and their impact on mainly one order parameter. Here we reveal a new mechanism for tuning both magnetism and ferroelectricity simultaneously by using VO. Combined experimental and density-functional theory studies of Eu0.5Ba0.5TiO3-{\delta}, we demonstrate that oxygen vacancies create Ti3+ 3d1 defect states, mediating the ferromagnetic coupling between the localized Eu 4f7 spins, and increase an off-center displacement of Ti ions, enhancing the ferroelectric Curie temperature. The dual function of Ti sites also promises a magnetoelectric coupling in the Eu0.5Ba0.5TiO3-{\delta}.Comment: Accepted by Physical Review B, 201

A Multi-Phase Transport model for nuclear collisions at RHIC

To study heavy ion collisions at energies available from the Relativistic Heavy Ion Collider, we have developed a multi-phase transport model that includes both initial partonic and final hadronic interactions. Specifically, the parton cascade model ZPC, which uses as input the parton distribution from the HIJING model, is extended to include the quark-gluon to hadronic matter transition and also final-state hadronic interactions based on the ART model. Predictions of the model for central Au on Au collisions at RHIC are reported.Comment: 7 pages, 4 figure