28 research outputs found

    The Commerce Clause and Criminal Law

    Get PDF
    The ongoing expansion of federal criminal law undermines the historical decentralization of criminal law in this country by usurping state authority in that area. While some protection of federalism is necessitated by the Supreme Court\u27s commerce power jurisprudence, the economic/non-economic distinction enunciated in United States v. Lopez is an unworkable return to past efforts to find internal limits to the Commerce Clause. Instead, a return to the test of National League of Cities v. Usery---yiewing the Tenth Amendment as an external limit on the scope of Congress\u27s Commerce Clause authority— is the best means of protecting the authority of the states to make and enforce criminal law

    Summary and Expert Witnesses: A Distinction with a Difference

    Get PDF

    The Impact of the GI Bill on Legal Education: A Case Study of Boston College Law School, 1949-1959

    Get PDF
    Describes the impact of the GI Bill on Boston College Law School. At a pivotal time in the school\u27s history, the GI Bill allowed hundreds of students to attend law school. In 1949 roughly 90% of the law school\u27s students were veterans

    Effects of Anacetrapib in Patients with Atherosclerotic Vascular Disease

    Get PDF
    BACKGROUND: Patients with atherosclerotic vascular disease remain at high risk for cardiovascular events despite effective statin-based treatment of low-density lipoprotein (LDL) cholesterol levels. The inhibition of cholesteryl ester transfer protein (CETP) by anacetrapib reduces LDL cholesterol levels and increases high-density lipoprotein (HDL) cholesterol levels. However, trials of other CETP inhibitors have shown neutral or adverse effects on cardiovascular outcomes. METHODS: We conducted a randomized, double-blind, placebo-controlled trial involving 30,449 adults with atherosclerotic vascular disease who were receiving intensive atorvastatin therapy and who had a mean LDL cholesterol level of 61 mg per deciliter (1.58 mmol per liter), a mean non-HDL cholesterol level of 92 mg per deciliter (2.38 mmol per liter), and a mean HDL cholesterol level of 40 mg per deciliter (1.03 mmol per liter). The patients were assigned to receive either 100 mg of anacetrapib once daily (15,225 patients) or matching placebo (15,224 patients). The primary outcome was the first major coronary event, a composite of coronary death, myocardial infarction, or coronary revascularization. RESULTS: During the median follow-up period of 4.1 years, the primary outcome occurred in significantly fewer patients in the anacetrapib group than in the placebo group (1640 of 15,225 patients [10.8%] vs. 1803 of 15,224 patients [11.8%]; rate ratio, 0.91; 95% confidence interval, 0.85 to 0.97; P=0.004). The relative difference in risk was similar across multiple prespecified subgroups. At the trial midpoint, the mean level of HDL cholesterol was higher by 43 mg per deciliter (1.12 mmol per liter) in the anacetrapib group than in the placebo group (a relative difference of 104%), and the mean level of non-HDL cholesterol was lower by 17 mg per deciliter (0.44 mmol per liter), a relative difference of -18%. There were no significant between-group differences in the risk of death, cancer, or other serious adverse events. CONCLUSIONS: Among patients with atherosclerotic vascular disease who were receiving intensive statin therapy, the use of anacetrapib resulted in a lower incidence of major coronary events than the use of placebo. (Funded by Merck and others; Current Controlled Trials number, ISRCTN48678192 ; ClinicalTrials.gov number, NCT01252953 ; and EudraCT number, 2010-023467-18 .)

    Function, Biological

    No full text
    corecore