Forschungsbericht : Entscheidungsprozesse in der Unternehmensnachfolge im Familienunternehmen : ein Prozessmodell

In der Schweiz wird innerhalb von fünf Jahren mit rund 60'000 und in Deutschland mit rund 350'000 Unternehmensnachfolgen gerechnet. Für die Schweiz wird geschätzt, dass es sich dabei um rund 60% Familienunternehmen handelt und in Deutschland um rund 80%. In der Schweiz wird mit rund 90'000 Arbeitsplätzen pro Jahr gerechnet, welche durch eine erfolgreiche oder nicht erfolgreiche Regelung der Nachfolge betroffen sind

NIR-spectroscopy for bioprocess monitoring & control

The Ingold port adaption of a free beam NIR spectrometer is tailored for optimal bioprocess monitoring and control. The device shows an excellent signal to noise ratio dedicated to a large free aperture and therefore a large sample volume. This can be seen particularly in the batch trajectories which show a high reproducibility. The robust and compact design withstands rough process environments as well as SIP/CIP cycles. Robust free beam NIR process analyzers are indispensable tools within the PAT/QbD framework for realtime process monitoring and control. They enable multiparametric, non-invasive measurements of analyte concentrations and process trajectories. Free beam NIR spectrometers are an ideal tool to define golden batches and process borders in the sense of QbD. Moreover, sophisticated data analysis both quantitative and MSPC yields directly to a far better process understanding. Information can be provided online in easy to interpret graphs which allow the operator to make fast and knowledge-based decisions. This finally leads to higher stability in process operation, better performance and less failed batches

Entscheidungsprozesse in der Unternehmensnachfolge im Familienunternehmen : ein Prozessmodell : Forschungsbericht

In der Schweiz wird innerhalb von fünf Jahren mit rund 60'000 und in Deutschland mit rund 350'000 Unternehmensnachfolgen gerechnet. Für die Schweiz wird geschätzt, dass es sich dabei um rund 60% Familienunternehmen handelt und in Deutschland um rund 80%. In der Schweiz wird mit rund 90'000 Arbeitsplätzen pro Jahr gerechnet, welche durch eine erfolgreiche oder nicht erfolgreiche Regelung der Nachfolge betroffen sind

Fluorescence resonance energy transfer in single enzyme molecules with a quantum dot as donor

3 FigurasH+-ATPsynthases couple a transmembrane proton transport with ATP synthesis and ATP hydrolysis. Previously, the relative subunit movement during this process has been measured by fluorescence resonance energy transfer (FRET) between two organic fluorophores covalently bound to different subunits. To improve the photophysical stability, a luminescent CdSe/ZnS nanocrystal (quantum dot) was bound to the enzyme and an organic fluorophore, Alexa568, was used as fluorescence acceptor. Single-molecule spectroscopy with the membrane integrated labeled H+-ATPsynthase was carried out. Single-pair FRET indicates three different conformations of the enzyme. During ATP hydrolysis relative intramolecular subunit movements are observed in real time.Eva M. Galvez was supported by the DeutscheForschungsgemeinschaft (DFG).Peer reviewe

Foundations in Swiss banking management

Zurich University of Applied Sciences (ZHAW) has trained Bachelor of Business Administration graduates (Bachelors of Science majoring in Banking and Finance) for a number of years. Up to now it has lacked a teaching guide for the introductory module on Banking Management. Therefore, the lecturing team from the Institute for Banking and Finance at ZHAW has taken the decision to incorporate their many years of professional and teaching experience into new teaching materials. Compendio Bildungsmedien AG supported the idea of the book project. This has resulted in a comprehensive Banking Management course guide which takes due account of the peculiarities of the Swiss banking industry. It is published in German and English because the ZHAW offers advanced studies in Banking and Finance in both languages. The first section focuses on the Swiss banking sector with its structures and how it is embedded in the institutional environment (macroeconomic assessment). The structure and history of the banking sector in Switzerland are explained, from its early days to the recent crises and consolidation trends. A separate chapter is given over to the peculiarities of Swiss financial market infrastructure, principally the Swiss Value Chain, as well as to the economic significance of the banking sector in relation to the monetary economy and monetary policy. The macroeconomic assessment is rounded off with the international accords on banking regulation and the so-called “Swiss Finish”, i.e. how international rules are transposed and supplemented in Switzerland. The second part looks at the most important areas of activity for individual banks (microeconomic assessment). The most important approaches in banking theory are presented and linked to the performance and value-added claim of banking organisations. The different business models, the organisational and informational-technology challenges, the services offered to meet clients’ heterogeneous needs, and approaches to creating client segments are explored in detail. Risk management, which is of immense importance to the success and survival capability of banks, is examined in a separate chapter. Finally, a bank’s accounting and controlling procedures are explained in detail; they differ significantly from those in other companies. Mapping banking transactions externally and in internal accounting also harbours particular conceptual challenges

Using enhanced development tools offered by analytical Quality by Design to support switching of an analytical quality control method

Quality by Design (QbD) principles play an increasingly important role in pharmaceutical industry. Here, we used an analytical QbD (AQbD) approach to develop a capillary electrophoresis method under reducing conditions (rCE-SDS), with the aim of replacing SDS-PAGE as release and stability test method for a commercialized monoclonal antibody product. Method development started with defining analytical method performance requirements as part of an analytical target profile (ATP), followed by a systematic risk assessment of method input parameters and their relation to defined method outputs. Based on this, design of experiments (DoE) studies were performed to identify a method operable design region (MODR). The MODR could be leveraged to improve method robustness. In a bridging study, it was demonstrated that the rCE-SDS method is more sensitive than the legacy SDS-PAGE method, and a correlation factor could be established to compensate for an off-set due to the higher sensitivity, without losing the correlation to the historical data acquired with the former method. Overall, systematic application of AQbD principles for designing and developing a new analytical method helped to elucidate the complex dependency of method outputs on its input parameters. The link of the method to critical quality attributes and the definition of method performance requirements were found to be most relevant for de-risking the analytical method switch, regarding impact on the control strategy