Statistical-Empirical Modelling of Aerofoil Noise Subjected to Leading Edge Serrations and Aerodynamic Identification of Noise Reduction Mechanisms

With the objective of reducing the broadband noise, emitted from the interaction of highly turbulent flow and aerofoil leading edge, sinusoidal leading edge serrations were analysed as an effective passive treatment. An extensive aeroacoustic study was performed in order to determine the main influences and interdependencies of factors, such as the Reynolds number (Re), turbulence intensity (Tu), serration amplitude (A/C) and wavelength (λ/C) as well as the angle of attack (AoA) on the noise reduction capability. A statistical-empirical model was developed to predict the overall sound pressure level and noise reduction of a NACA65(12)- 10 aerofoil with and without leading edge serrations in the analysed range of chord-based Reynolds numbers of 2.5·105 ≤ Re ≤ 6·105 and a geometrical angle of attack -10 deg ≤ α ≤ +10 deg. The observed main influencing factors match current research results to a high degree, and were quantified in a systematic order for the first time. Moreover, significant interdependencies of the turbulence intensity and the serration wavelength (Tu·λ/C), as well as the serration wavelength and the angle of attack (λ/C·AoA) were observed, validated and quantified. In order to study the noise reduction mechanisms, Particle Image Velocimetry (PIV) measurements were conducted upstream of the aerofoil leading edge and along the interstices of the leading edge serrations. Velocity, turbulence intensity and vorticity in the plane perpendicular to the main flow direction (y/z plane) were analysed and linked to the acoustic findings. It was observed that a noise reduction is accompanied by a reduction of the turbulence intensity within the serration interstices. The reduction in turbulence intensity is more pronounced with large serration amplitudes. However, the impact of the serration wavelength was found to be no function of the turbulence. It is more likely to be affected acoustically by spanwise de-correlation effects as a response to the incoming gusts

Garlic and ginger are not like apples and oranges: Effects of mass/count information on the production of noun phrases in English

In this study a picture–word interference paradigm was used to investigate how grammatical mass/count information is processed during noun phrase production in English. Theories of lexical processing distinguish between two different types of lexical–syntactic information: variable extrinsic lexical–syntactic features, such as number (singular, plural), and fixed intrinsic lexical–syntactic properties, such as grammatical gender (e.g., masculine, feminine). Previous research using the picture–word interference paradigm has found effects of distractor lexical–syntactic congruency for grammatical gender but no congruency effects for number. We used this phenomenon to investigate whether mass/count information is processed similarly to grammatical gender. In two experiments, participants named pictures of mass or count objects using determiner noun phrases (e.g., Experiment 1 with mass and plural count nouns: “not muchmass ricemass”, “not manycount pegscount”; Experiment 2 with mass and singular count nouns: “some ricemass”, “a pegcount”), while ignoring distractors that were countability congruent or incongruent nouns. The results revealed a countability congruency effect for mass and plural count nouns in Experiment 1 and for singular count nouns, but not mass nouns in Experiment 2. This is similar to grammatical gender suggesting that countability processing is predominantly driven by a noun’s lexical–syntactic information. © 2017 The Experimental Psychology Societ

Safety of the SQ tree sublingual immunotherapy tablet: Pooled safety analysis of clinical trials

Background The standardized quality (SQ) tree sublingual immunotherapy (SLIT)-tablet has recently been approved for treatment of tree pollen allergy. Healthcare workers should be provided with detailed safety data for clinical use. Objective To assess the tolerability and safety of the SQ tree SLIT-tablet (12 SQ-Bet) in adults and adolescents. Methods Safety data were pooled from three double-blinded, randomized, placebo-controlled trials (2 phase-II/1 phase-III) including adults and adolescents 12-65 years with allergic rhinitis and/or conjunctivitis treated before and during one pollen season once-daily with 12 SQ-Bet (n = 471) or placebo (n = 458): EudraCT no: 2012-000031-59; NCT02481856; EudraCT 2015-004821-15. Results The most frequently reported investigational medicinal product (IMP)-related AEs with 12 SQ-Bet were oral pruritis (39% of subjects) and throat irritation (29%). IMP-related AEs were mainly mild or moderate in severity, and the majority resolved without treatment and did not lead to treatment interruption/discontinuation. With 12 SQ-Bet, oral pruritus was more frequent among subjects with pollen food syndrome (PFS) (45%) than without PFS (29%). The 12 SQ-Bet did not seem to induce an increased risk of asthma: 7 events were reported in 7 subjects with 12 SQ-Bet and 11 in 10 subjects with placebo. No differences were seen in the risk of moderate-to-severe IMP-related AEs regardless of age, PFS status and asthma medical history. Conclusions The 12 SQ tree SLIT-tablet was well tolerated in tree pollen allergic subjects with no major safety concerns detected. This safety profile supports daily at-home sublingual administration once the first dose is tolerated when administered under medical supervision.Peer reviewe

Evaluation of Forensic DNA Traces When Propositions of Interest Relate to Activities : Analysis and Discussion of Recurrent Concerns

When forensic scientists evaluate and report on the probative strength of single DNA traces, they commonly rely on only one number, expressing the rarity of the DNA profile in the population of interest. This is so because the focus is on propositions regarding the source of the recovered trace material, such as “the person of interest is the source of the crime stain.” In particular, when the alternative proposition is “an unknown person is the source of the crime stain,” one is directed to think about the rarity of the profile. However, in the era of DNA profiling technology capable of producing results from small quantities of trace material (i.e., non-visible staining) that is subject to easy and ubiquitous modes of transfer, the issue of source is becoming less central, to the point that it is often not contested. There is now a shift from the question “whose DNA is this?” to the question “how did it get there?” As a consequence, recipients of expert information are now very much in need of assistance with the evaluation of the meaning and probative strength of DNA profiling results when the competing propositions of interest refer to different activities. This need is widely demonstrated in day-to-day forensic practice and is also voiced in specialized literature. Yet many forensic scientists remain reluctant to assess their results given propositions that relate to different activities. Some scientists consider evaluations beyond the issue of source as being overly speculative, because of the lack of relevant data and knowledge regarding phenomena and mechanisms of transfer, persistence and background of DNA. Similarly, encouragements to deal with these activity issues, expressed in a recently released European guideline on evaluative reporting (Willis et al., 2015), which highlights the need for rethinking current practice, are sometimes viewed skeptically or are not considered feasible. In this discussion paper, we select and discuss recurrent skeptical views brought to our attention, as well as some of the alternative solutions that have been suggested. We will argue that the way forward is to address now, rather than later, the challenges associated with the evaluation of DNA results (from small quantities of trace material) in light of different activities to prevent them being misrepresented in court

Drosophila modifier screens to identify novel neuropsychiatric drugs including aminergic agents for the possible treatment of Parkinson's disease and depression.

Small molecules that increase the presynaptic function of aminergic cells may provide neuroprotection in Parkinson's disease (PD) as well as treatments for attention deficit hyperactivity disorder (ADHD) and depression. Model genetic organisms such as Drosophila melanogaster may enhance the detection of new drugs via modifier or 'enhancer/suppressor' screens, but this technique has not been applied to processes relevant to psychiatry. To identify new aminergic drugs in vivo, we used a mutation in the Drosophila vesicular monoamine transporter (dVMAT) as a sensitized genetic background and performed a suppressor screen. We fed dVMAT mutant larvae ∼ 1000 known drugs and quantitated rescue (suppression) of an amine-dependent locomotor deficit in the larva. To determine which drugs might specifically potentiate neurotransmitter release, we performed an additional secondary screen for drugs that require presynaptic amine storage to rescue larval locomotion. Using additional larval locomotion and adult fertility assays, we validated that at least one compound previously used clinically as an antineoplastic agent potentiates the presynaptic function of aminergic circuits. We suggest that structurally similar agents might be used to development treatments for PD, depression and ADHD, and that modifier screens in Drosophila provide a new strategy to screen for neuropsychiatric drugs. More generally, our findings demonstrate the power of physiologically based screens for identifying bioactive agents for select neurotransmitter systems

Helping to distinguish primary from secondary transfer events for trace DNA.

DNA is routinely recovered in criminal investigations. The sensitivity of laboratory equipment and DNA profiling kits means that it is possible to generate DNA profiles from very small amounts of cellular material. As a consequence, it has been shown that DNA we detect may not have arisen from a direct contact with an item, but rather through one or more intermediaries. Naturally the questions arising in court, particularly when considering trace DNA, are of how DNA may have come to be on an item. While scientists cannot directly answer this question, forensic biological results can help in discriminating between alleged activities. Much experimental research has been published showing the transfer and persistence of DNA under varying conditions, but as of yet the results of these studies have not been combined to deal with broad questions about transfer mechanisms. In this work we use published data and Bayesian networks to develop a statistical logical framework by which questions of transfer mechanism can be approached probabilistically. We also identify a number of areas where further work could be carried out in order to improve our knowledge base when helping to address questions about transfer mechanisms. Finally, we apply the constructed Bayesian network to ground truth known data to determine if, with current knowledge, there is any power in DNA quantities to distinguish primary and secondary transfer events

Crystallographic structure of ultrathin Fe films on Cu(100)

We report bcc-like crystal structures in 2-4 ML Fe films grown on fcc Cu(100) using scanning tunneling microscopy. The local bcc structure provides a straightforward explanation for their frequently reported outstanding magnetic properties, i.e., ferromagnetic ordering in all layers with a Curie temperature above 300 K. The non-pseudomorphic structure, which becomes pseudomorphic above 4 ML film thickness is unexpected in terms of conventional rules of thin film growth and stresses the importance of finite thickness effects in ferromagnetic ultrathin films.Comment: 4 pages, 3 figures, RevTeX/LaTeX2.0