Increased Osteoclastogenesis in Mice Lacking the Carcinoembryonic Antigen-Related Cell Adhesion Molecule 1

Alterations in bone remodeling are a major public health issue, as therapeutic options for widespread bone disorders such as osteoporosis and tumor-induced osteolysis are still limited. Therefore, a detailed understanding of the regulatory mechanism governing bone cell differentiation in health and disease are of utmost clinical importance. Here we report a novel function of carcinoembryonic antigen-related cell adhesion molecule 1 (CEACAM1), a member of the immunoglobulin superfamily involved in inflammation and tumorigenesis, in the physiologic regulation of bone remodeling. Assessing the expression of all members of the murine Ceacam family in bone tissue and marrow, we found CEACAM1 and CEACAM10 to be differentially expressed in both bone-forming osteoblasts and bone-resorbing osteoclasts. While Ceacam10-deficient mice displayed no alteration in structural bone parameters, static histomorphometry demonstrated a reduced trabecular bone mass in mice lacking CEACAM1. Furthermore, cellular and dynamic histomorphometry revealed an increased osteoclast formation in Ceacam1-deficient mice, while osteoblast parameters and the bone formation rate remained unchanged. In line with these findings, we detected accelerated osteoclastogenesis in Ceacam1-deficient bone marrow cells, while osteoblast differentiation, as determined by mineralization and alkaline phosphatase assays, was not affected. Therefore, our results provide in vivo and in vitro evidence for a physiologic role of CEACAM1 in the regulation of osteoclastogenesis

The Grizzly, September 9, 2004

Make a Difference: How to Register to Vote • Computer Thefts Under Investigation • Republicans say Yes to Four More Years with Bush • A Costly Look at Carelessness • STAR Sponsors One Night • Turnpike Tolls Increase for Commuters • Insider\u27s Tips to Undergraduate and Graduate Awards • Been to Synagogue Lately? • Safety First • Segregation by Letter? • The Pop-up Problem • UC Fringe Festival Opens Wednesday • Parking at Ursinus Robs Convenience • Opinions: Is Technology Making Life Easier or Lazier?; Life During Wartime; Lick it, Stamp it, Mail it and then Rock the Vote • 2004 Bears Football Outlook • UC Hires new Cross Country / Track & Field Coach • Now that Stanton is Gone: Men\u27s Basketball Preview • Bearcox Preview • Olympic Games: Competitive or Controversial?https://digitalcommons.ursinus.edu/grizzlynews/1563/thumbnail.jp

First deployment of a multi-barrel sea floor drill rig on the Antarctic continental shelf: experiences from the MARUM-MeBo70 on Polarstern-Expedition PS104

The MARUM-MeBo (abbreviation for Meeresboden-Bohrgerät, the German expression for seafloor drill rig) is a robotic drilling system that is developed since 2004 at the MARUM Center for Marine Environmental Sciences at the University of Bremen in close cooperation with Bauer Maschinen GmbH and other industry partners. The MARUM-MeBo drill rigs can be deployed from multipurpose research vessel like, RV MARIA S. MERIAN, RV METEOR, RV SONNE and RV POLARSTERN and are used for getting long cores both in soft sediments as well as hard rocks in the deep sea. The first generation drill rig, the MARUM-MeBo70 is dedicated for drilling depths of more than 70 m (Freudenthal and Wefer, 2013). Between 2005 and 2017 it was deployed on 18 research expeditions and drilled more than. 3 km into different types of lithologies including carbonate and crystalline rocks, gas hydrates, sands and gravel, glacial till and hemipelagic mud with an average recovery rate of 67 %. In February and March 2017 the MeBo70 was used on the West Antarctic continental shelf in the Amundsen Sea Embayment for the first time. The goal of the deployment on RV Polarstern expedition PS104 was to recover a series of sediment cores from different ages that will provide material for investigating the glaciation history of this area known as the most dynamic drainage area of the West Antarctic Ice Sheet. In this presentation we will focus on the operational experiences of this first deployment of a multi-barrel sea floor drill rig on the Antarctic continental shelf. References: Freudenthal, T and Wefer, G (2013) Drilling cores on the sea floor with the remote-controlled sea floor drilling rig MeBo. Geoscientific Instrumentation, Methods and Data Systems, 2(2). 329-337. doi:10.5194/gi-2-329-201

First results of sedimentological investigations of MeBo drill cores recovered from the West Antarctic continental shelf in the Amundsen Sea

During expedition PS104 with RV Polarstern in February and March 2017 the MARUM MeBo 70 seabed drilling system was deployed at nine sites on the continental shelf of the Amundsen Sea Embayment, West Antarctica. A total of 57 meters of sediment core were recovered from 11 boreholes located in Pine Island Bay, Pine Island Trough, Bear Ridge and Cosgrove-Abbot Trough with recovery rates ranging from 7 to 76%. The main scientific objective of the drilling was to reconstruct the Late Mesozoic to Quaternary environmental history in this part of the Antarctic continental margin, with a special focus on the past dynamics of the marine based West Antarctic Ice Sheet (WAIS) from its inception to the last glacial cycle. Another main goal of the expedition was to test the suitability of the MeBo drill system for operating on the Antarctic continental shelf and recovering pre-glacial and glacially influenced sedimentary sequences. Here we will present the first results of sedimentological investigations carried out on the drill cores. These comprise (i) visual lithological descriptions, (ii) CT-scanning records of core stratigraphy, sedimentary structures, and possible artefacts induced by the drilling process, (iii) measurements of physical properties performed with a multi-sensor core logger, and (iv) characterisation of the geochemical composition of the drilled sedimentary strata using X-ray fluorescence (XRF) scanner data. Preliminary biostratigraphic investigations conducted on board ship indicated that the recovered sedimentary strata were deposited during various time slices spanning from the Late Cretaceous–Palaeocene to the Late Quaternary. We will provide an update of these initial chronological findings. Keywords: Drill cores, shelf sediments, West Antarctic Ice Sheet

Application of Carbon Dioxide Snow in Machining of CGI using an Additively Manufactured Turning Tool

The application of conventional cooling lubricants for the tribological conditioning of machining processes involves high additional costs and health risks. The application of a cryogenic carbon dioxide (CO₂) snow cooling strategy is an economical and environmentally sound alternative for oily cooling emulsions since it has a high cooling effect as well as a residue-free sublimation. This article introduces a laser additive manufactured tool holder with an integrated dual nozzle which enables CO₂-snow jet application. Initially this work focuses on the characterization and the selection of a suitable nozzle geometry. The modular tool body features an adapted channel structure for process-reliable and targeted CO₂-snow cooling for turning processes. This enables the simultaneous cooling of the rake and flank face with CO₂-snow, as well as the application of cryogenic multi-component cooling of the rake face. In the context of this study, the focus lies on the technological evaluation of three different supply strategies during the continuous turning of compacted graphite iron CGI-450 at increased cutting speed. It was established that an efficient rake face cooling is indispensable to achieve a low thermal tool load, and thus lower crater wear behavior. Therefore, this study contributes to an improvement in cryogenic machining processes regarding the design of additively manufactured tool bodies for process-reliable CO₂-snow cooling, as well as for the selection of supply strategies to minimize the thermomechanical tool load