A Volumetric Survey of Focusing and Electrostatic Contributions to Protein RNA Interactions

Electrostatic focusing has been shown to be a major component in DNA to protein interfaces. Since ribonucleic acid molecules are notoriously less consistent and uniform in structure than their DNA cousins, electrostatic focusing has not yet been evaluated between RNA and protein. This is the first survey of its kind showing the occurrence of focusing with specific amino acids and RNA secondary structures. With unique volumetric tools we quantify the electrostatic focusing phenomena in RNA and look at its impact on the electrostatic component of protein affinity. With those same tools we uncover which amino acids interact with focusing regions and how much they interface with those regions. We also demonstrate what types of secondary structures in RNA are commonly associated with electrostatic focusing

Case Studies for a Markov Chain Approach to Analyze Agent-Based Models

Agent-Based Models have become a widely used tool in social sciences, health care management and other disciplines to describe complex systems from a bottom-up perspective. Some reasons for that are the easy understanding of Agent-Based Models, the high flexibility and the possibility to describe heterogeneous structures. Nevertheless problems occur when it comes to analyzing Agent-Based Models. This paper shows how to describe Agent-Based Models in a macroscopic way as Markov Chains, using the random map representation. The focus is on the implementation of this method for chosen examples of a Random Walk and Opinion Dynamic Models. It is also shown how to use Markov Chain tools to analyze these models. Our case studies imply that this method can be a powerful tool when it comes to analyzing Agent-Based Models although some further research in practice is still necessary

Case Studies for a Markov Chain Approach to Analyze Agent-Based Models

Agent-Based Models have become a widely used tool in social sciences, health care management and other disciplines to describe complex systems from a bottom-up perspective. Some reasons for that are the easy understanding of Agent-Based Models, the high flexibility and the possibility to describe heterogeneous structures. Nevertheless problems occur when it comes to analyzing Agent-Based Models. This paper shows how to describe Agent-Based Models in a macroscopic way as Markov Chains, using the random map representation. The focus is on the implementation of this method for chosen examples of a Random Walk and Opinion Dynamic Models. It is also shown how to use Markov Chain tools to analyze these models. Our case studies imply that this method can be a powerful tool when it comes to analyzing Agent-Based Models although some further research in practice is still necessary

Auf den Spuren J. A.Silbermanns: Interview mit Katrin Bicher

Erfahrungsbericht aus der Welt der sozialen Medien. Die Sächsische Landesbibliothek – Staats- und Universitätsbibliothek Dresden (SLUB) hat Anfang dieses Jahres mit dem Reisetagebuch des Straßburger Orgelbauers Johann Andreas Silbermann (1712–1783) eine einzigartige Neuerwerbung in den Bestand der Musikabteilung integriert (siehe auch BIS 2015, H. 1, S. 18–20). Darin beschreibt der Neffe von Gottfried Silbermann eine viermonatige Reise nach Mitteldeutschland und Berlin im Jahr 1741. Im Unterschied zum vollständig veröffentlichten SiIbermann-Archiv in französischem Privatbesitz blieb dieses Tagebuch bislang völlig unbekannt. Es bietet einen faszinierenden Einblick in das Musikleben kultureller Zentren in Deutschland zur Zeit Johann Sebastian Bachs. Den Ankauf des Reisetagebuchs hat Katrin Bicher, Fachreferentin der SLUB mit einem eigenen Silbermann-Twitterkanal begleitet. Die BIS-Redaktion fragte Sie zum „Making off“ und der Intention dieser Aktivitäten in den sozialen Medien

Clinical Thermoradiotherapy

A clinical trial is currently in progress to determine the efficacy of combined fractions of hyperthermia and radiation. The protocol consists of two parts. First, four fractions of microwave-induced hyperthermia (45.0° ± 0.5°C) are applied for 1 1/2 hours to the volume encompassing the tumor, each separated by 72 hours. After a one-week rest, a second series of four fractions is administered again at 72- hour intervals. Each fraction consists of a 400 rad dose of radiation followed within 20 minutes by hyperthermia (42.5 ± 0.5°C) for 1 1/2 hours. Currently, we have treated 62 patients with 82 fields with a mean follow-up time of six months to date. Total regression was observed in 60% of all cases, and partial regression in 33%; no response was seen in only 6% of all those treated. Five local and three marginal recurrences have been observed. This paper discusses details of response based on site, histology, and classification

Definition, Validation and Comparison of Two Population Models for Austria

In this work we present two structurally different mathematical models for the prognostic simulation of Austria’s population: A time-continuous, macroscopic system dynamics approach and a time-discrete, microscopic agent-based approach. Both models were developed as case studies of a series of population concepts in order to support models for decision-support in Austria’s health care system. In the present work we want to focus on the definition, the parametrisation as well as especially the validation process of both population-models. The latter was of special interest as it included a cross-model validation with Statistics Austria’s own prognostic model SIKURS

Definition, Validation and Comparison of Two Population Models for Austria

In this work we present two structurally different mathematical models for the prognostic simulation of Austria’s population: A time-continuous, macroscopic system dynamics approach and a time-discrete, microscopic agent-based approach. Both models were developed as case studies of a series of population concepts in order to support models for decision-support in Austria’s health care system. In the present work we want to focus on the definition, the parametrisation as well as especially the validation process of both population-models. The latter was of special interest as it included a cross-model validation with Statistics Austria’s own prognostic model SIKURS

A Further Perspective on Data Stewardship: Experiences and Challenges of "RDM-Stewards" in a Collaborative Project in Rhineland-Palatinate

Poster presented at the Data Stewardship Goes Germany Workshop at SLUB Dresden.This research and development project is funded by the German Federal Ministry of Education and Research (BMBF) within the funding measure Reuse and Management of Research Data at Universities of Applied Sciences (funding number 16FDFH104A) and financed within the Recovery and Resilience Facility of the European Union

A Web-based Platform for E-Learning and Blended Learning in Modelling and Simulation

The Mathematics Modelling and Tools (MMT) e-learning system is a platform used for supporting lectures and tutoring at the Vienna University and Technology. Additionally to traditional e-learning properties like up- and download of lecture notes, videos and slides the MMT system provides the surface for a virtual modelling and simulation laboratory. Very powerful calculation software like MATLAB, Java or Octave, running in behind, allows experimenting with targeted modelling and simulation examples prepared and developed by experts. These are first of all used to support the presentation directly at the lecture and can afterwards be accessed by students given a password at home. As especially MATLAB also allows development of suitable examples dealing with mathematics, so far about ten percent of all examples treat this specific topic and are used in math lectures. It showed that especially the live experience fiddling on pre-implemented examples poses a big improvement for lectures

A Web-based Platform for E-Learning and Blended Learning in Modelling and Simulation

The Mathematics Modelling and Tools (MMT) e-learning system is a platform used for supporting lectures and tutoring at the Vienna University and Technology. Additionally to traditional e-learning properties like up- and download of lecture notes, videos and slides the MMT system provides the surface for a virtual modelling and simulation laboratory. Very powerful calculation software like MATLAB, Java or Octave, running in behind, allows experimenting with targeted modelling and simulation examples prepared and developed by experts. These are first of all used to support the presentation directly at the lecture and can afterwards be accessed by students given a password at home. As especially MATLAB also allows development of suitable examples dealing with mathematics, so far about ten percent of all examples treat this specific topic and are used in math lectures. It showed that especially the live experience fiddling on pre-implemented examples poses a big improvement for lectures