Syntax-driven program verification of matching logic properties

We describe a novel approach to program verification and its application to verification of C programs, where properties are expressed in matching logic. The general approach is syntax-directed: semantic rules, expressed according to Knuths attribute grammars, specify how verification conditions can be computed. Evaluation is performed by interplaying attribute computation and propagation through the syntax tree with invocation of a solver of logic formulae. The benefit of a general syntax-driven approach is that it provides a reusable reference scheme for implementing verifiers for different languages. We show that the instantiation of a general approach to a specific language does not penalize the efficiency of the resulting verifier. This is done by comparing our C verifier for matching logic with an existing tool for the same programming language and logic. A further key advantage of the syntax-directed approach is that it can be the starting point for an incremental verifier -- which is our long-term research target

Conceptualizing throughput legitimacy: procedural mechanisms of accountability, transparency, inclusiveness and openness in EU governance

This symposium demonstrates the potential for throughput legitimacy as a concept for shedding empirical light on the strengths and weaknesses of multi-level governance, as well as challenging the concept theoretically. This article introduces the symposium by conceptualizing throughput legitimacy as an ‘umbrella concept’, encompassing a constellation of normative criteria not necessarily empirically interrelated. It argues that in order to interrogate multi-level governance processes in all their complexity, it makes sense for us to develop normative standards that are not naïve about the empirical realities of how power is exercised within multilevel governance, or how it may interact with legitimacy. We argue that while throughput legitimacy has its normative limits, it can be substantively useful for these purposes. While being no replacement for input and output legitimacy, throughput legitimacy offers distinctive normative criteria— accountability, transparency, inclusiveness and openness— and points towards substantive institutional reforms.Published versio

A syntactic-semantic approach to incremental verification

Software verification of evolving systems is challenging mainstream methodologies and tools. Formal verification techniques often conflict with the time constraints imposed by change management practices for evolving systems. Since changes in these systems are often local to restricted parts, an incremental verification approach could be beneficial. This paper introduces SiDECAR, a general framework for the definition of verification procedures, which are made incremental by the framework itself. Verification procedures are driven by the syntactic structure (defined by a grammar) of the system and encoded as semantic attributes associated with the grammar. Incrementality is achieved by coupling the evaluation of semantic attributes with an incremental parsing technique. We show the application of SiDECAR to the definition of two verification procedures: probabilistic verification of reliability requirements and verification of safety properties

Incremental syntactic-semantic reliability analysis of evolving structured workflows

Modern enterprise information systems are built following the paradigm of service-orientation. This paradigm promotes workflow-based software composition, where complex business processes are realized by orchestrating different, heterogenous components. These workflow descriptions evolve continuously, to adapt to changes in the business goals or in the enterprise policies. Software verification of evolving systems is challenging mainstream methodologies and tools. Formal verification techniques often conflict with the time constraints imposed by change management practices for evolving systems. Since changes in these systems are often local to restricted parts, an incremental verification approach could be beneficial. In this paper we focus on the probabilistic verification of reliability requirements of structured workflows. We propose a novel incremental technique based on a syntactic-semantic approach. Reliability analysis is driven by the syntactic structure (defined by an operator-precedence grammar) of the workflow and encoded as semantic attributes associated with the grammar. Incrementality is achieved by coupling the evaluation of semantic attributes with an incremental parsing technique. The approach has been implemented in a prototype tool; preliminary experimental evaluation confirms the theoretical speedup over a nonincremental approach

Insulin-degrading enzyme (IDE): a novel heat shock-like protein.

Insulin-degrading enzyme (IDE) is a highly conserved zinc metallopeptidase that is ubiquitously distributed in human tissues, and particularly abundant in the brain, liver, and muscles. IDE activity has been historically associated with insulin and beta-amyloid catabolism. However, over the last decade, several experimental findings have established that IDE is also involved in a wide variety of physiopathological processes, including ubiquitin clearance and Varicella Zoster Virus infection. In this study, we demonstrate that normal and malignant cells exposed to different stresses markedly up-regulate IDE in a heat shock protein (HSP)-like fashion. Additionally, we focused our attention on tumor cells and report that (i) IDE is overexpressed in vivo in tumors of the central nervous system (CNS); (ii) IDE-silencing inhibits neuroblastoma (SHSY5Y) cell proliferation and triggers cell death; (iii) IDE inhibition is accompanied by a decrease of the poly-ubiquitinated protein content and co-immunoprecipitates with proteasome and ubiquitin in SHSY5Y cells. In this work, we propose a novel role for IDE as a heat shock protein with implications in cell growth regulation and cancer progression, thus opening up an intriguing hypothesis of IDE as an anticancer target

Adequacy of Pain Management in Patients Referred for Radiation Therapy: A Subanalysis of the Multicenter ARISE-1 Study

Background: Pain is a prevalent symptom among cancer patients, and its management is crucial for improving their quality of life. However, pain management in cancer patients referred to radiotherapy (RT) departments is often inadequate, and limited research has been conducted on this specific population. This study aimed to assess the adequacy and effectiveness of pain management when patients are referred for RT. Moreover, we explored potential predictors of adequate pain management. Methods: This observational, prospective, multicenter cohort study included cancer patients aged 18 years or older who were referred to RT departments. A pain management assessment was conducted using the Pain Management Index (PMI), calculated by subtracting the pain score from the analgesic score (PMI < 0 indicated inadequate pain management). Univariate and multivariate analyses were performed to identify predictors of adequate pain management. Results: A total of 1042 cancer outpatients were included in the study. The analysis revealed that 42.9% of patients with pain did not receive adequate pain management based on PMI values. Among patients with pain or taking analgesics and referred to palliative or curative RT, 72% and 75% had inadequate or ineffective analgesic therapy, respectively. The odds of receiving adequate pain management (PMI ≥ 0) were higher in patients undergoing palliative RT (OR 2.52; p < 0.001), with worse ECOG-PS scores of 2, 3 and 4 (OR 1.63, 2.23, 5.31, respectively; p: 0.017, 0.002, 0.009, respectively) compared to a score of 1 for those with cancer-related pain (OR 0.38; p < 0.001), and treated in northern Italy compared to central and southern of Italy (OR 0.25, 0.42, respectively; p < 0.001). Conclusions: In this study, a substantial proportion of cancer patients referred to RT departments did not receive adequate pain management. Educational and organizational strategies are necessary to address the inadequate pain management observed in this population. Moreover, increasing the attention paid to non-cancer pain and an earlier referral of patients for palliative RT in the course of the disease may improve pain response and treatment outcomes

On-The-Fly Model-Based Testing of Web Services with Jambition

Increasing complexity and massive use of current web services raise multiple issues for achieving adequate service validation while sticking to time-to-market imperatives. For instance: How to automate test case generation and execution for stateful web services? How to realistically simulate web service related operation calls? How to ensure conformance to specifications? The Plastic validation framework tackles some of these issues by providing specific tools for automated model-based functional testing. Based on the Symbolic Transition System model, test cases can be generated and executed on-the-fly. This test-ing approach was applied for validating the Alarm Dispatcher eHealth service, aimed at providing health attention through mobile devices in B3G networks. In this paper we report how this modeling and testing ap-proach helped to detect failures, support conformance, and reduce drastically the testing effort spent usually in designing test cases, validating test coverage, and executing test cases in traditional testing approaches