The role of magnetic field for quiescence-outburst models in CVs

In this paper we present the elementary assumptions of our research on the role of the magnetic field in modelling the quiescence-outbursts cycle in Cataclysmic Variables (CVs). The behaviour of the magnetic field is crucial not only to integrate the disk instability model (Osaki 1974), but also to determine the cause and effect nexus among parameters affecting the behavior of complex systems. On the ground of our interpretation of the results emerging from the literature, we suggest that in models describing DNe outbursts, such as the disk instability model, the secondary instability model (Bath 1973) and the thermonuclear runaway model (Mitrofanov 1978), the role of the magnetic field is at least twofold. On the one hand, it activates a specific dynamic pathway for the accreting matter by channelling it. On the other hand, it could be indirectly responsible for switching a particular outburst modality. In order to represent these two roles of the magnetic field, we need to integrate the disk instability model by looking at the global behaviour of the system under analysis. Stochastic resonance in dynamo models, we believe, is a suitable candidate for accomplishing this task. We shall present the MHD model including this mechanism elsewhere.Comment: 5 pages, 2 figures, CTU Proceedings, Acta Polytechnica (accepted

Limitations of PLL simulation: hidden oscillations in MatLab and SPICE

Nonlinear analysis of the phase-locked loop (PLL) based circuits is a challenging task, thus in modern engineering literature simplified mathematical models and simulation are widely used for their study. In this work the limitations of numerical approach is discussed and it is shown that, e.g. hidden oscillations may not be found by simulation. Corresponding examples in SPICE and MatLab, which may lead to wrong conclusions concerning the operability of PLL-based circuits, are presented

The broad-band X-ray spectrum of the Seyfert 1 galaxy, MCG+8-11-11

We present a long (100 ks) Suzaku observation of one of the X-ray brightest AGN, MCG+8-11-11. These data were complemented with the 54-month Swift BAT spectrum, allowing us to perform a broad-band fit in the 0.6-150 keV range. The fits performed in the 0.6-10 keV band give consistent results with respect to a previous XMM-Newton observation, i.e. the lack of a soft excess, warm absorption along the line of sight, a large Compton reflection component (R~1) and the absence of a relativistic component of the neutral iron K$\alpha$ emission line. However, when the PIN and Swift BAT data are included, the reflection amount drops significantly (R~0.2-0.3), and a relativistic iron line is required, the latter confirmed by a phenomenological analysis in a restricted energy band (3-10 keV). When a self-consistent model is applied to the whole broadband data, the observed reflection component appears to be all associated to the relativistic component of the iron K$\alpha$ line. The resulting scenario, though strongly model-dependent, requires that all the reprocessing spectral components from Compton-thick material must be associated to the accretion disc, and no evidence for the classical pc-scale torus is found. The narrow core of the neutral iron K$\alpha$ line is therefore produced in a Compton-thin material, like the BLR, similarly to what found in another Seyfert galaxy, NGC7213, but with the notable difference that MCG+8-11-11 presents spectral signatures from an accretion disc. The very low accretion rate of NGC7213 could explain the lack of relativistic signatures in its spectrum, but the absence of the torus in both sources is more difficult to explain, since their luminosities are comparable, and their accretion rates are completely different.Comment: 8 pages, 6 figure, accepted for publication in Astronomy and Astrophysic

In-Medium Properties of Hadrons

A diverse experimental program for the study of the photoproduction of mesons off nuclei has been carried out - and is still running - at the Mainz MAMI and Bonn ELSA electron accelerators with the TAPS, Crystal Barrel, and Crystal Ball calorimeters. It is motivated as a detailed study of the in-medium properties of hadrons and the meson - nucleus interactions. Typical examples for the in-medium behavior of vector mesons ($\omega$), scalar mesons ($\sigma$), and nucleon resonances (P$_{33}$(1232), S$_{11}$(1535), D$_{15}$(1520)) are discussed. Special attention is paid to meson - nucleus final state interactions.Comment: Proceedings of the Meson2006 IX Int. Workshop on Production, Properties and Interaction of Mesons, Cracow, Poland 09 - 14 June, 2006, to be published in Int. J. Mod. Phys.

New linearization and reweighting for simulations of string sigma-model on the lattice

We study the discretized worldsheet of Type IIB strings in the Gubser-Klebanov-Polyakov background in a new setup, which eliminates a complex phase previously detected in the fermionic determinant. A sign ambiguity remains, which a study of the fermionic spectrum shows to be related to Yukawa-like terms, including those present in the original Lagrangian before the linearization standard in a lattice QFT approach. Monte Carlo simulations are performed in a large region of the parameter space, where the sign problem starts becoming severe and instabilities appear due to the zero eigenvalues of the fermionic operator. To face these problems, simulations are conducted using the absolute value of a fermionic Pfaffian obtained introducing a small twisted-mass term, acting as an infrared regulator, into the action. The sign of the Pfaffian and the low modes of the quadratic fermionic operator are then taken into account by a reweighting procedure of which we discuss the impact on the measurement of the observables. In this setup we study bosonic and fermionic correlators and observe a divergence in the latter, which we argue - also via a one-loop analysis in lattice perturbation theory - to originate from the U(1)-breaking of our Wilson-like discretization for the fermionic sector

Identifying short motifs by means of extreme value analysis

The problem of detecting a binding site -- a substring of DNA where transcription factors attach -- on a long DNA sequence requires the recognition of a small pattern in a large background. For short binding sites, the matching probability can display large fluctuations from one putative binding site to another. Here we use a self-consistent statistical procedure that accounts correctly for the large deviations of the matching probability to predict the location of short binding sites. We apply it in two distinct situations: (a) the detection of the binding sites for three specific transcription factors on a set of 134 estrogen-regulated genes; (b) the identification, in a set of 138 possible transcription factors, of the ones binding a specific set of nine genes. In both instances, experimental findings are reproduced (when available) and the number of false positives is significantly reduced with respect to the other methods commonly employed.Comment: 6 pages, 5 figure

Biological aspects of mTOR in leukemia

The mammalian target of rapamycin (mTOR) is a central processor of intra-and extracellular signals, regulating many fundamental cellular processes such as metabolism, growth, proliferation, and survival. Strong evidences have indicated that mTOR dysregulation is deeply implicated in leukemogenesis. This has led to growing interest in the development of modulators of its activity for leukemia treatment. This review intends to provide an outline of the principal biological and molecular functions of mTOR. We summarize the current understanding of how mTOR interacts with microRNAs, with components of cell metabolism, and with controllers of apoptotic machinery. Lastly, from a clinical/translational perspective, we recapitulate the therapeutic results in leukemia, obtained by using mTOR inhibitors as single agents and in combination with other compounds