A nitroreductase and glutathione responsive nanoplatform for integration of gene delivery and near-infrared fluorescence imaging

A novel platform rationally integrating indocyanine green analogues and an arginine-rich dendritic peptide with both nitroreductase (NTR) and glutathione (GSH) reduction responsive linkers was developed. This multifunctional platform can enable selective and efficient gene delivery and specific turn-on fluorescence imaging in tumors.Drug Delivery Technolog

Use of a novel cytotoxic HEXIM1 peptide in the directed breast cancer therapy

10.18632/oncotarget.6794Oncotarget755483-549