Formulation and Evaluation of Chitosan-Gellan Beads as Controlled Drug Delivery System of Antihypertensive Drug

The use of natural polymers in the design of drug delivery formulation has received much attention due to their excellent biocompatibility and biodegradability. Among them, chitosan and gellan are very promising and have been widely exploited in pharmaceutical industry for controlled drug release. In the present study, an attempt has been made to formulate chitosan-gellan beads of Diltiazem hydrochloride using chitosan and gellan as ionic polysaccharide, and calcium chloride as cross-linking agent. The formulations were prepared by varying the concentration of gellan gum and chitosan. The prepared beads were evaluated for drug polymer interaction by FT-IR, DSC andsurface morphology by SEM. Drug content, swelling studies and in vitro drug release were carried out on prepared beads. FT-IR and DSC studies showed no interaction between drug and polymers. SEM showed spherical nature of beads with inward dents. Swelling of beads depends upon pH, concentration of polymers and crosslinking agent. The in vitro release of drug from beads was controlled for 12 h. Chitosan-gellan beads as controlled drug delivery were prepared by changing the polymer concentration. Swelling studies showed that with an increase in pH from acidic to basic, a considerable increase in swelling in all the formulations was observed

Pelvic pressure packing for intractable obstetric and gynaecological hemorrhage in a tertiary care hospital

Background: Haemorrhage is one of the most common complication of any surgery. Haemorrhage can be arterial, venous or capillary ooze. Massive haemorrhage if not timely managed may lead to fatal consequences. There are various medical and surgical methods to control haemorrhage. This study aims to achieve hemostasis with the help of pelvic pressure pack in Obstetric and Gynaecologic surgeries when standard methods are failed and to evaluate efficacy of simple and modified technique of pack preparation.Methods: This is an observational study of 11 cases conducted over a period of 4yrs. This study reports modification of standard packing techniques which overcomes some of its limitations. Here the pack was used in different gynaecologic and Obstetric cases, where intractable haemorrhage was the major problem and standard methods to control haemorrhage had failed. Here a simple foley’s catheter rolled with condom and filled with normal saline was used to prepare a pack and kept over the bleeding surface. This specific pack will adopt the shape of the body cavity it is inserted into, thereby causing pressure tamponade against bleeding surfaces. Pack was removed after 48-72 hours of insertion. Postoperative control of bleeding, patient stability and morbidity were studied.Results: The pelvic pressure pack successfully controlled bleeding in 100% of cases without any morbidity and mortality.Conclusions: In the contemporary management of post-hysterectomy or adhesiolysis induced uncontrolled pelvic bleeding and venous oozes, the pelvic pressure pack appears to be valuable and effective option, affording correction of coagulopathy and further stabilization. We believe all Obstetricians and Gynaecologists should be familiar with this simple safe and cheap potentially lifesaving technique

pH Dependent Molecular Self-Assembly of Octaphosphonate Porphyrin of Nanoscale Dimensions: Nanosphere and Nanorod Aggregates

Self-assembled nanostructures of zwitterionic octaphosphanatoporphyrin 1, of either nanoparticles or nanorods, depending on small changes in the pH, is demonstrated based on the J-aggregates. Porphyrin 1 self-assembled into nanosphere aggregates with a diameter of about 70–80 nm in the pH range 5–7, and nanorod aggregates were observed at pH 8.5. Hydrogen bonding, π-π stacking and hydrophilic interactions play important roles in the formation of this nanostructure morphology. Nanostructures were characterized by UV/Vis absorbance, fluorescence, atomic force microscopy (AFM) and transmission electron microscopy (TEM). This interesting pH dependent self-assembly phenomenon could provide a basis for development of novel biomaterials

Carbon nanotube: An indirect ~ 0 eV band gap material

Thin film of carbon was synthesized from camphor (C10H16O) by CVD technique in hydrogen atmosphere. For the first time it is confirmed the presence of almost zero indirect band gap in addition to its direct band gap.. Carrier concentration with intrinsic carbon is found to be around 1021 n/cm3. It is suggested that unless the zero indirect band gap is increased carbon thin film cannot be used for making a p:n junction. XRD, Raman and SEM analysis are performed

Trimethoprim-sulfamethoxazole induced toxic epidermal necrolysis: a case report

Toxic epidermal necrolysis (TEN) is a rare but serious dermatological disorder commonly caused as an idiosyncratic reaction to drugs and the most common drugs implicated are antibiotics, anticonvulsants and non-steroidal anti-inflammatory drugs. Here, we report a case of trimethoprim-sulfamethoxazole induced TEN in a 26 years old female

Review Paper-Social networking with protecting sensitive labels in data Anonymization

The use of social network sites goes on increasing such as facebook, twitter, linkedin, live journal social network and wiki vote network. By using this, users find that they can obtain more and more useful information such as the user performance, private growth, dispersal of disease etc. It is also important that users private information should not get disclose. Thus, Now a days it is important to protect users privacy and utilization of social network data are challenging. Most of developer developed privacy models such as K-anonymity for protecting node or vertex reidentification in structure information. Users privacy models get forced by other user, if a group of node largely share the same sensitive labels then other users easily find out one’s data ,so that structure anonymization method is not purely protected. There are some previous approaches such as edge editing or node clustering .Here structural information as well as sensitive labels of individuals get considered using K-degree l-deversityanonymity model. The new approach in anonymization methodology is adding noise nodes. By considering the least distortion to graph properties,the development of new algorithm using noise nodes into original graph. Most important it will provide an analysis of no.of noise nodes added and their impact on important graph property

CORRELATION OF NUTRITIONAL STATUS OF MOTHER AND THE BIRTH WEIGHT OF THE BABY

Objective: The objective of this study is to correlate mother's nutritional status during pregnancy and determine the birth weight of the baby.Methods: A comparative, exploratory approach and prospective cohort study design was used to find out mothers' nutritional status during pregnancy influences the birth weight of babies. The data were collected using structured interview schedule and dietary history by 24 h recall method from a randomly selected sample of 380 eligible mothers delivered at Krishna Hospital, Karad.Results: There was a significant correlation between birth weight and calorie intake (correlation coefficient [r]=0.595; p<0.001; Chi-square=201.3; p<0.001.) A higher proportion of low birth weight babies, i.e., 105 (32.2%) were delivered by the mothers consuming <70% of protein ([r]=0.245; p<0.001; χ2=24.033; p<0.001]). There was correlation between birth weight and calcium intake of mothers ([r]=0.525; p<0.001; χ2=10.12; p<0.001] birth†weight and iron intake of mothers ([r]=0.250; p<0.001; χ2=13.798; p<0.001).Conclusion: The intake of calorie, protein, calcium, and iron of mother can significantly influence the weight of the newborn baby. Among all anthropometric parameters of the mother, weight gain was the strongest predictor of adequacy of the birth weight

Kinetic and Mechanistic Study of Glucose Isomerization Using Homogeneous Organic Brønsted Base Catalysts in Water

The isomerization of glucose to fructose represents a key intermediate step in the conversion of cellulosic biomass to fuels and renewable platform chemicals, namely, 5-hydroxymethyl furfural (HMF), 2,5-furandicarboxylic acid (FDCA), and levulinic acid (LA). Although both Lewis acids and Brønsted bases catalyze this reaction, the base-catalyzed pathway received significantly less attention due to its lower selectivity to fructose and the poor yields achieved (\u3c10%). However, we recently demonstrated that homogeneous organic Brønsted bases present a similar performance (∼31% yield) as Sn-containing beta zeolite, a reference catalyst for this reaction. Herein, we report on the first extensive kinetic and mechanistic study on the organic Brønsted base-catalyzed isomerization of glucose to fructose. Specifically, we combine kinetic experiments performed over a broad range of conditions (temperature: 80–120 °C; pH 9.5–11.5; reactant: glucose, fructose) with isotopic studies and in situ 1H NMR spectroscopy. Pathways leading to isomerization and degradation of the monosaccharides have been identified through careful experimentation and comparison with previously published data. Kinetic isotope effect experiments were carried out with labeled glucose to validate the rate-limiting step. The ex situ characterization of the reaction products was confirmed using in situ 1H NMR studies. It is shown that unimolecular (thermal) and bimolecular (alkaline) degradation of fructose can be minimized independently by carefully controlling the reaction conditions. Fructose was produced with 32% yield and 64% selectivity within 7 min