Bacteriological Spectrum and Sensitivity Pattern in Culture Proven Urinary Tract Infection in Children

To determine the different types of organisms causing urinary tract infections in children and their sensitivity to antibiotics.Methods: This cross sectional study was conducted at Children Hospital, PIMS Islamabad and consisted of 117 patients of either gender between age of 03 months to 12 years.Results: Mean age of children enrolled in our study was 4.4 (± 2.6) years. Out of 117 patients, 63 (54 %) were girls. The most common isolate was E. coli (57.3%) percent, followed by Klebsiella (18.8 %), Staphylococcus aureus (13.7 %), Pseudomonas (5.1 %) and Proteus (3.4 %) children. All isolates were sensitive to ciprofloxacin, of loxacin, amikacin, cefixime and imepenem. Only 38.5% E coli and 37.5% Klebsiella were sensitive to Ampicillin, and 14.3% E coli and 9.1% Klebsiella were sensitive to Trimethoprim-sulphamethoxazole.Conclusion: The most common isolate was E. coli, followed by Klebsiella, Staphylococcus aureus, Pseudomonas and Proteus. Most antibiotics tested for the E. coli, Klebsiella, Staphylococcus, Pseudomonas and Proteus are effective except Cotrimoxazole, Ampicillin, and Gentamicin which show high resistanc

Impact of Organization Commitment on Turnover Intention: Mediating Role of Job Contentment

Basis purpose of this research is to find out the impact of organizational commitment on turnover intension. Literature on organizational commitment and turnover intention depicted that organizational commitment has profound impact on turnover intension. Further influence of job satisfaction as mediator was also investigated. Data was collected through the questionnaires from 200 employees of banking sector of Faisalabad. To test the hypothesis, correlation and regression analysis is carried out using SPSS 20.0. Results of the statistical analysis indicated significantly negative relationship between organizational commitment and turnover intension and significant positive relationship between organizational commitment and job satisfaction. Result of the research concludes that job satisfaction partially mediates the relationship between organizational commitment and turnover intension. Keywords: Organizational commitment, affective commitment, continuous commitment, normative commitment, Job satisfaction, turnover intension

Methylation and loss of Imprinting: Unending rivalries unleashed between “kneaded erasers†and “fate writersâ€Â

Genome is a complex barcode that is interpreted at molecular level. There are various proteins which are modulating the expression or repression of the genes. Miscellaneous proteins work in collaboration to stimulate or repress the gene expression. Chromatin remodeling factors are the artists which chisel, carve and mould the sculpture of genome. In this review we will emphasize on exemptions and extensions which trigger genomic instability in broad range of molecular anomalies. Doubtlessly therapeutic interventions have shown tremendous promise in cancer therapy, but the selectivity profiles of these compounds have largely relied on serendipity or 'off-target' activities rather than rational drug design. Purposefully designed compounds with activity against methyltransferase, demethylase and HDAC will bring us a step closer to personalized medicine

Spatial variations in COVID-19 risk perception and coping mechanism in Pakistan

The outbreak of novel coronavirus disease (COVID-19) was declared a pandemic by the World Health Organization, which instigated governments to impose lockdowns across their countries. Amidst the lockdown in Pakistan, this study comprised measures of the COVID-19 risk perception, coping mechanism, and spatial variations. The data from 40 selected indicators was collected using an online questionnaire and grouped into domains (4 risk perception and 3 coping mechanisms domains). The results revealed the spatial variations and the levels of risk perception and coping mechanisms within the study area. Relative to each other, overall risk perception was highest in Northern Areas (Gilgit-Baltistan and Azad Jammu and Kashmir) and Islamabad, and lowest in Balochistan province. Very little spatial variation was observed in terms of coping mechanisms. Age, gender, and marital status influenced the risk perception associated with COVID-19. The findings suggest spatial variation in risk perception, implying the need for localized and modified COVID-19 risk communication and risk reduction strategies. SUPPLEMENTARY INFORMATION: The online version contains supplementary material available at 10.1007/s41324-022-00498-7

A cross sectional study on the risk factors of gallbladder stone

Background: Gallstone diseases are one of the most common public health problems. Approximately 10%-20% of the national adult populations currently carry gallstones, and gallstone prevalence is rising. The purpose of the study was to find out association of gallstone with fatty liver, gender and age in Lahore, Pakistan.Methods: Ultrasonographically Hundred patients were scanned for liver type and gall stone. The data was analyzed by using SPSS version 17.0. Chi-Square statistics was used to check the association between the variables. The effect of age and gender was also statistically analysed.Results: One hundred patients were scanned between ages 21-60 years. Out of hundred 76% patients were female and 24% were male. In this study there were no stones in 37% cases and there were stones in 63% cases. Gallbladder stone found associated with age as p-value is found less than 5% level of significance, maximum patients were found in age ranges between 31-35 years, showing that risk of developing gallstone increases by age. Gallstone is gender specific, females are more victims of developing the stone than among males, and those who have fatty liver are more at risk of developing gallstone than those having normal liver.Conclusions: The study showed that ultrasound (US) is the most sensitive, specific, yet very practical and useful imaging test for the detection of gallstones with a high degree of confidence. Gallstones represent high prevalence disease in adult females more than males and it increases by age where as those who have fatty liver, they are more likely to develop gallstone

Urinary Amylase as the First Line Diagnostic Tool for Acute Pancreatitis

Background: Diagnosis of acute pancreatitis is based on raised serum lipase and serum amylase in the blood. However, the levels of urinary amylase can be sought for being less invasive. The study aimed to find out the diagnostic accuracy of urinary amylase compared to serum amylase and serum lipase and their association with the degree of severity of acute pancreatitis. Methods: A randomized clinical control study was conducted on n=180 acute pancreatitis patients (18-50 year) in the Ziauddin and PNS Shifa Hospital, Karachi from September 2019- August 2020. Serum amylase, serum lipase and urinary amylase levels were checked at the time of admission followed by 24 hours and at discharge. ANOVA with post-hoc Tuckey’s test was used to determine the association of amylases with the severity of acute pancreatitis and p˂0.05 was considered as statistically significant. Results: The patients with acute pancreatitis had a mean age of 51.76 ±10.8. Urinary amylase had a strong significant association (p˂0.05) with acute pancreatitis compared to serum amylase and lipase (p=0.024). There was an insignificant association of urinary amylase with acute pancreatitis after 24 hours. Similarly, urinary amylase reported good diagnostic discrimination of acute pancreatitis as the accuracy index, the area under the ROC curve was one, showing higher sensitivity and specificity by covering the maximum population under the ROC curve. Conclusion: The significance of Urinary amylase (p˂0.05) was higher than serum amylase, serum lipase because of sensitivity and specificity for diagnosing acute pancreatitis representing a positive association with the degree of severity of the disease. Keywords: Acute Pancreatitis; Amylase; Lipase; Amylase

The Changing Role of Urdu News Media with Digital Communication in Pakistan

The growing use of digital media has influenced significantly the communication channels of society during recent years in the globe. The media and communication in Pakistan is transforming with information technology. The marvelous boost of digital media devices has changed the communication channels. With digital media revolution, the people in society who formerly had no chance to participate, now they have a great opportunity of to contribute. They can give feedback on news content, comment on stories and share information. If we talk about Urdu news in Pakistan, technology has not left it unchanged. The great revolution in technological field has modified the way public receives information on various aspects. This research work will boost our understanding of how effects of fast spreading technological means have affected traditional modes of Urdu news. During the past decades, western world has got a great benefit from immense development in information communication technology. Furthermore, developing world is widely seen accepting access to internet computer and mobile phone technology. Today's media organizations are extensively using various technological sources. This study also explore the phenomenon of adoption of information technology, role played by media in this digital age and to address the global audience and news collection, influence of internet and extent of freedom of expression to which it has impacted todays media in accessing and delivering information. Though traditional modes of information have got a great jolt by new digital platform and have brought great opportunities for information gathering ofUrdu news in Pakistan.</p

Analysis and enhancement of the denoising depth data using kinect through iterative technique

Since the release of Kinect by Microsoft, the, accuracy and stability of Kinect data-such as depth map, has been essential and important element of research and data analysis. In order to develop efficient means of analyzing and using the kinnect data, researchers require high quality of depth data during the preprocessing step, which is very crucial for accurate results. One of the most important concerns of researchers is to eliminate image noise and convert image and video to the best quality. In this paper, different types of the noise for Kinect are analyzed and a unique technique is used, to reduce the background noise based on distance between Kinect devise and the user. Whereas, for shadow removal, the iterative method is used to eliminate the shadow casted by the Kinect. A 3D depth image is obtained as a result with good quality and accuracy. Further, the results of this present study reveal that the image background is eliminated completely and the 3D image quality in depth map has been enhanced

On Distribution Grid Optimal Power Flow Development and Integration

Due to changes in electric distribution grid operation, new operation regimes have been recommended. Distribution grid optimal power flow (DOPF) has received tremendous attention in the research community, yet it has not been fully adopted across the utility industry. Our paper recognizes this problem and suggests a development and integration procedure for DOPF. We propose development of DOPF as a three step procedure of 1) processing the grid, 2) obtaining a tractable solution, and 3) implementing multiple solution algorithms and benchmarking them to improve application reliability. For the integration of DOPF, we demonstrate how a DOPF federate may be developed that can be integrated in a co-simulation environment to mimic the real-world conditions and hence improve its practicality to be deployed in the field. To demonstrate the efficacy of the proposed methods, tests on IEEE 123-bus system are performed where the usage of tractable formulation in DOPF algorithm development and its comparison to the benchmark solution are demonstrated