Stellar Populations in Bulges

We present line strengths in the bulges and inner disks of 38 galaxies in the local universe, including several galaxies whose bulges were previously identified as being disk-like in their colors or kinematics, to see if their spectral properties reveal evidence for secular evolution. We find that red bulges of all Hubble types are similar to luminous ellipticals in their central stellar populations. They have large luminosity-weighted ages, metallicities, and alpha/Fe ratios. Blue bulges can be separated into a metal-poor class that is restricted to late-types with small velocity dispersion and a young, metal-rich class that includes all Hubble types and velocity dispersions. Luminosity-weighted metallicities and alpha/Fe ratios are sensitive to central velocity dispersion and maximum disk rotational velocity. Red bulges and ellipticals follow the same scaling relations. We see differences in some scaling relations between blue and red bulges and between bulges of barred and unbarred galaxies. Most bulges have decreasing metallicity with increasing radius; galaxies with larger central metallicities have steeper gradients. Where positive age gradients (with the central regions being younger) are present, they are invariably in barred galaxies. The metallicities of bulges are correlated with those of their disks. While this and the differences between barred and unbarred galaxies suggest that secular evolution cannot be ignored, our results are generally consistent with the hypothesis that mergers have been the dominant mechanism responsible for bulge formation.Comment: 30 pages, 21 figures; submitted to MNRA

Use of Various Bio-Fencing Plants in the Control of Human Diseases by the Lambada Tribe Inhabiting Nalgonda District, Andhra Pradesh, India

The present paper deals with 16 bio-fencing plants, which are being used for control of various diseases in human beings by Lambada tribes of Nalgonda District, Andhra Pradesh. The biomedicines are collected from the plants, which are used as fencing plants to their agricultural fields. This work is being carried out in collaboration with local Lambada tribes of Manchya Naik Thanda of Nalgonda district. The documented ethno medicine information was indexed by plant name, family, local name and uses

Identification of MHC Class II Binders/ Non-binders using Negative Selection Algorithm

The identification of major histocompatibility complex (MHC) class-II restricted peptides is an important goal in human immunological research leading to peptide based vaccine design. These MHC class–II peptides are predominantly recognized by CD4+ T-helper cells, which when turned on, have profound immune regulatory effects. Thus, prediction of such MHC class-II binding peptides is very helpful towards epitope-based vaccine design. HLA-DR proteins were found to be associated with autoimmune diseases e.g. HLA-DRB1*0401 with rheumatoid arthritis. It is important for the treatment of autoimmune diseases to determine which peptides bind to MHC class II molecules. The experimental methods for identification of these peptides are both time consuming and cost intensive. Therefore, computational methods have been found helpful in classifying these peptides as binders or non-binders. We have applied negative selection algorithm, an artificial immune system approach to predict MHC class–II binders and non-binders. For the evaluation of the NSA algorithm, five fold cross validation has been used and six MHC class–II alleles have been taken. The average area under ROC curve for HLA-DRB1*0301, DRB1*0401, DRB1*0701, DRB1*1101, DRB1*1501, DRB1*1301 have been found to be 0.75, 0.77, 0.71, 0.72, and 0.69, and 0.84 respectively indicating good predictive performance for the small training set

Compact Floor-Planning via Orderly Spanning Trees

Floor-planning is a fundamental step in VLSI chip design. Based upon the concept of orderly spanning trees, we present a simple O(n)-time algorithm to construct a floor-plan for any n-node plane triangulation. In comparison with previous floor-planning algorithms in the literature, our solution is not only simpler in the algorithm itself, but also produces floor-plans which require fewer module types. An equally important aspect of our new algorithm lies in its ability to fit the floor-plan area in a rectangle of size (n-1)x(2n+1)/3. Lower bounds on the worst-case area for floor-planning any plane triangulation are also provided in the paper.Comment: 13 pages, 5 figures, An early version of this work was presented at 9th International Symposium on Graph Drawing (GD 2001), Vienna, Austria, September 2001. Accepted to Journal of Algorithms, 200

Flux free growth of large FeSe1/2Te1/2 superconducting single crystals by an easy high temperature melt and slow cooling method

We report successful growth of flux free large single crystals of superconducting FeSe1/2Te1/2 with typical dimensions of up to few cm. The AC and DC magnetic measurements revealed the superconducting transition temperature (Tc) value of around 11.5K and the iso-thermal MH showed typical type-II superconducting behavior. The lower critical field being estimated by measuring the low field iso-thermal magnetization in superconducting regime is found to be above 200 Oe at 0K.Comment: 15 pages text + Figs. Novel large cm size FeSe1/2Te1/2 superconducting crystal

GRAPHICAL TECHNIQUES IN DEBIASING: AN EXPLORATORY STUDY

Base rate and conjunction fallacies are consistent biases that influence decision making involving probability judgments. We develop simple graphical techniques and test their efficacy in correcting for these biases. Preliminary results suggest that graphical techniques help to overcome these biases and improve decision making. We examine the implications of incorporating these simple techniques in Executive Information Systems.Information Systems Working Papers Serie

Nanoformulated cell-penetrating survivin mutant and its dual actions

In this study, we investigated the differential actions of a dominant-negative survivin mutant (SurR9-C84A) against cancerous SK-N-SH neuroblastoma cell lines and differentiated SK-N-SH neurons. In both the cases, the mutant protein displayed dual actions, where its effects were cytotoxic toward cancerous cells and proliferative toward the differentiated neurons. This can be explained by the fact that tumorous (undifferentiated SK-N-SH) cells have a high endogenous survivin pool and upon treatment with mutant SuR9-C84A causes forceful survivin expression. These events significantly lowered the microtubule dynamics and stability, eventually leading to apoptosis. In the case of differentiated SK-N-SH neurons that express negligible levels of wild-type survivin, the mutant indistinguishably behaved in a wild-type fashion. It also favored cell-cycle progression, forming the chromosome-passenger complex, and stabilized the microtubule-organizing center. Therefore, mutant SurR9-C84A represents a novel therapeutic with its dual actions (cytotoxic toward tumor cells and protective and proliferative toward neuronal cells), and hence finds potential applications against a variety of neurological disorders. In this study, we also developed a novel poly(lactic-co-glycolic acid) nanoparticulate formulation to surmount the hurdles associated with the delivery of SurR9-C84A, thus enhancing its effective therapeutic outcome