Biodiversity Tools For Boosting Immune System Of Homosapiens: An In Vitro Study Of Abutilon Indicium Leaves

Climate change is attributed directly or indirectly to human activity that alters the compositions of the global atmosphere. Human beings are both agents and victims of environmental change. Therefore, climate change is the main reason for the environmental challenge that the world faces today. To overcome these negative impact on human health, biodiversity has given powerful tools and healing powers in the form of plants and herbs for boosting human body’s immune system which keeps homosapiens finally strong, hale and healthy. Many complex diseases including heart problems require long and expensive treatment which common man in developing countries cannot afford. India has a long history for the treatment of various diseases using traditional medicinal plants. In contrast to synthetic compounds, herbal products are safer with minimum side effects and preferred largely for the treatment of various ailments. Thromboembolism involving the arterial or venous circulation or arising from the heart is a common cause of morbidity and mortality. India with its numerous plants variety offers costless method and inexpensive treatment to a number of disorders such as thromboembolism. The present study explores how to find out the in vitro anticoagulant activities of abutilon indicium leaves extracts, in addition to comparing and contrasting the findings with othersimilarstudiesauthoredbyanumberof medical practitioner

A study in the seroprevalence of hepatitis B core antibody and other transfusion transmitted infections in blood donors

Background:Hepatitis B virus (HBV) infection can lead to acute or chronic hepatitis. There is a phase during which the HBsAg cannot be detected in the blood, although hepatitis B infection is present. During this window period, detection of the antibody to the hepatitis B core antigen (anti-HBc) serves as a useful serological marker for hepatitis B infection. This study was undertaken to detect the Hepatitis B core antibody and other transfusion transmitted infections (HBsAg, HIV, HCV, Malaria and Syphilis) among healthy blood donors in the Kancheepuram district, TamilNadu and its impact in our blood transfusion services.Methods: A total of 6954 blood donors were selected. 5 ml of blood from each donor was collected from the collection bag into a sterile capped tube. It was then centrifuged and the plasma was sepa-rated and stored as two aliquots at -70°C till further use. The screening for the Hepatitis B core antibody (anti-HBc) was done by a competitive immunoassay technique with ortho clinical diagnostics Anti-HBc (IgM and IgG) reagent kit and were run in a fully automated Vitros Immunodiagnostics system.Results: Of the total 6954 donor blood samples which were tested, 713 samples (10.2%) were found to be positive for anti-HBc (IgM and IgG) and 93 samples (1.3%) were found to be positive for HBsAg.Conclusions: Our study helped in determining the prevalence of hepatitis B core antibody and its subsequent detrimental effect on the blood donor population due to its high prevalence rate.

Climate Change: Coping Strategies For A Sustainable Future In India

Today, human race faces many threats but none is greater than the climate challenge. I quote Ban Ki-moon, the Secretary General of UN, “ climate change does not respect borders; it does not respect who you are-rich and, the poor, small and big. Therefore, this is what we call ‘ global challenges’ which require global solidarity”-co-operation and collaboration among all people and all governments of the world. Our globe, is a world of looming climate challenges. Climate change is happening here and happening now. Hence, human beings should not become architects of their own destruction. With the available knowledge and tools, it is essential to reduce global warming in terms of the mitigation and adaptation strategies. Therefore, this paper delineates various climate change coping strategies followed all over the world with a detailed description of measures formulated and adopted in India

Evaluation of academic stress among medical students using graphology and machine learning algorithm in correlation with salivary cortisol

Background: Stress is a part of the academic life of graduates. Young adults are especially susceptible to academic stress based on their subjective commitment towards academic goals, and social pressure for superior academic performance. Recognizing academic stress is crucial for planning successful management, and to prevent mental illness. The aim of the study was to develop methods to identify stress using graphology, machine learning algorithm and salivary cortisol.Methods: The study included a mixed method research design and   enrolled 43 medical students (19 males and 24 females) between 18-23 years of age were taken in the present study. The Kessler psychological distress scale (K10) was used to ascertain distress among the study subjects.Results: Students written manuscript images were taken for artificial intelligence training and analysis. The written   manuscript was evaluated for positive and negative personality traits using graphology techniques. One of the negative traits identified by graphology, i.e.; dejection, it was used to train a machine learning tool to identify the negative trait of dejection.Conclusions: This study suggests that mental health professionals can train machine learning algorithms, using graphology tools, to function as a screening tool to determine stress levels. This may help to plan for management and recovery of stressed individuals and help them in future academic performance

Effect of angiotensin-converting enzyme inhibitor and angiotensin receptor blocker initiation on organ support-free days in patients hospitalized with COVID-19

IMPORTANCE Overactivation of the renin-angiotensin system (RAS) may contribute to poor clinical outcomes in patients with COVID-19. Objective To determine whether angiotensin-converting enzyme (ACE) inhibitor or angiotensin receptor blocker (ARB) initiation improves outcomes in patients hospitalized for COVID-19. DESIGN, SETTING, AND PARTICIPANTS In an ongoing, adaptive platform randomized clinical trial, 721 critically ill and 58 non–critically ill hospitalized adults were randomized to receive an RAS inhibitor or control between March 16, 2021, and February 25, 2022, at 69 sites in 7 countries (final follow-up on June 1, 2022). INTERVENTIONS Patients were randomized to receive open-label initiation of an ACE inhibitor (n = 257), ARB (n = 248), ARB in combination with DMX-200 (a chemokine receptor-2 inhibitor; n = 10), or no RAS inhibitor (control; n = 264) for up to 10 days. MAIN OUTCOMES AND MEASURES The primary outcome was organ support–free days, a composite of hospital survival and days alive without cardiovascular or respiratory organ support through 21 days. The primary analysis was a bayesian cumulative logistic model. Odds ratios (ORs) greater than 1 represent improved outcomes. RESULTS On February 25, 2022, enrollment was discontinued due to safety concerns. Among 679 critically ill patients with available primary outcome data, the median age was 56 years and 239 participants (35.2%) were women. Median (IQR) organ support–free days among critically ill patients was 10 (–1 to 16) in the ACE inhibitor group (n = 231), 8 (–1 to 17) in the ARB group (n = 217), and 12 (0 to 17) in the control group (n = 231) (median adjusted odds ratios of 0.77 [95% bayesian credible interval, 0.58-1.06] for improvement for ACE inhibitor and 0.76 [95% credible interval, 0.56-1.05] for ARB compared with control). The posterior probabilities that ACE inhibitors and ARBs worsened organ support–free days compared with control were 94.9% and 95.4%, respectively. Hospital survival occurred in 166 of 231 critically ill participants (71.9%) in the ACE inhibitor group, 152 of 217 (70.0%) in the ARB group, and 182 of 231 (78.8%) in the control group (posterior probabilities that ACE inhibitor and ARB worsened hospital survival compared with control were 95.3% and 98.1%, respectively). CONCLUSIONS AND RELEVANCE In this trial, among critically ill adults with COVID-19, initiation of an ACE inhibitor or ARB did not improve, and likely worsened, clinical outcomes. TRIAL REGISTRATION ClinicalTrials.gov Identifier: NCT0273570

DESIGN AND FABRICATION OF BUTTON OPERATED ELECTROMAGNETIC GEAR CHANGER FOR FOUR STROKE PETROL ENGINE TWO WHEELER VEHICLE

ABSTRACT A rotational output of an internal combustion engine is connected to drive wheel s of the automobile and a load device. when a gear shifting up of an automobile trasnmiosson is to effected. the load applied by the load device is increased, or the load connected to an output rotation shaft of the engine via selectivity connecting devic

In silico studies of (2E,5E)-2,5-bis(3-methoxy-4-hydroxy-benzylidene) cyclopentanone on proteins AChE and BChE involved in alzheimer's disease and ameliorative effects on paraquat induced oxidative stress markers in drosophila melanogaster

In the present study, the ameliorative effect of a bischalcone (2E,5E)-2,5-bis(3-methoxy-4-hydroxy-benzylidene) cyclopentanone (CA), a curcumin analog was studied on Drosophila melanogaster (oregon K strain) in vivo by inducing oxidative stress using paraquat. Curcumin (CU) was taken as standard for studies. In negative geotaxis assay it was found that CA was able to rescue the flies significantly from deteriorating locomotor dysfunctions. A docking study for antialzeimer's activity of CA was carried out by targeting the proteins Acetylcholinesterase (AChE) and Butyrylcholinesterase (BChE). It binds effectively to the target proteins