HI Fluctuations at Large Redshifts: II - the Signal Expected for GMRT

For the GMRT, we calculate the expected signal from redshifted HI emission at two frequency bands centered at 610 and 325 MHz. The study focuses on the visibility-visibility cross-correlations, proposed earlier as the optimal statistical estimator for detecting and analyzing this signal. These correlations directly probe the power spectrum of density fluctuations at the redshift where the radiation originated, and thereby provide a method for studying the large scale structures at large redshifts. We present detailed estimates of the correlations expected between the visibilities measured at different baselines and frequencies. Analytic fitting formulas representing the salient features of the expected signal are also provided. These will be useful in planning observations and deciding an optimal strategy for detecting this signal.Comment: 16 pages including 7 figures, published in JAp

The multi-frequency angular power spectrum of the epoch of reionization 21 cm signal

Observations of redshifted 21cm radiation from HI at high redshifts is an important future probe of reionization. We consider the Multi-frequency Angular Power Spectrum (MAPS) to quantify the statistics of the HI signal as a joint function of the angular multipole l and frequency separation \Delta\nu. The signal at two different frequencies is expected to get decorrelated as \Delta\nu is increased, and quantifying this decorrelation is particularly important in deciding the frequency resolution for future HI observations. This is also expected to play a very crucial role in extracting the signal from foregrounds as the signal is expected to decorrelate much faster than the foregrounds (which are largely continuum sources) with increasing \Delta\nu. In this paper we develop formulae relating the MAPS to different components of the three dimensional HI power spectrum taking into account HI peculiar velocities. We show that the flat-sky approximation provides a very good representation over the angular scales of interest, and a final expression which is very simple to calculate and interpret. We present results considering two models for the HI distribution, namely, (i) DM: where the HI traces the dark matter and (ii) PR: where the effects of patchy reionization are incorporated through two parameters. We find that while the DM signal is largely featureless, the PR signal peaks at the angular scales of the individual bubbles, and the signal is considerably enhanced for large bubble size. For most cases of interest at l \sim 100 the signal is uncorrelated beyond \Delta\nu \sim 1 MHz or even less, whereas it occurs around \sim 0.1 MHz at l \sim 10^3. The \Delta\nu dependence also carries an imprint of the bubble size and the bias, and is expected to be an important probe of the reionization scenario (abridged).Comment: Accepted for publication in MNRAS. Revised to match the accepted versio

The CMBR ISW and HI 21-cm Cross-correlation Angular Power Spectrum

The late-time growth of large scale structures (LSS) is imprinted in the CMBR anisotropy through the Integrated Sachs Wolfe (ISW) effect. This is perceived to be a very important observational probe of dark energy. Future observations of redshifted 21-cm radiation from the cosmological neutral hydrogen (HI) distribution hold the potential of probing the LSS over a large redshift range. We have investigated the possibility of detecting the ISW through cross-correlations between the CMBR anisotropies and redshifted 21-cm observations. Assuming that the HI traces the dark matter, we find that the ISW-HI cross-correlation angular power spectrum at an angular multipole l is proportional to the dark matter power spectrum evaluated at the comoving wave number l/r, where r is the comoving distance to the redshift from which the HI signal originated. The amplitude of the cross-correlation signal depends on parameters related to the HI distribution and the growth of cosmological perturbations. However the cross-correlation is extremely weak as compared to the CMBR anisotropies and the predicted HI signal. As a consequence the cross-correlation signal is smaller than the cosmic variance, and a statistically significant detection is not very likely.Comment: 13 pages, 4 eps figures, submitte

Characterisation of the structure and oligomerisation of islet amyloid polypeptides (IAPP): A review of molecular dynamics simulation studies

Human islet amyloid polypeptide (hIAPP) is a naturally occurring, intrinsically disordered protein whose abnormal aggregation into amyloid fibrils is a pathological feature in type 2 diabetes, and its cross-aggregation with amyloid beta has been linked to an increased risk of Alzheimer’s disease. The soluble, oligomeric forms of hIAPP are the most toxic to ß-cells in the pancreas. However, the structure of these oligomeric forms is difficult to characterise because of their intrinsic disorder and their tendency to rapidly aggregate into insoluble fibrils. Experimental studies of hIAPP have generally used non-physiological conditions to prevent aggregation, and they have been unable to describe its soluble monomeric and oligomeric structure at physiological conditions. Molecular dynamics (MD) simulations offer an alternative for the detailed characterisation of the monomeric structure of hIAPP and its aggregation in aqueous solution. This paper reviews the knowledge that has been gained by the use of MD simulations, and its relationship to experimental data for both hIAPP and rat IAPP. In particular, the influence of the choice of force field and water models, the choice of initial structure, and the configurational sampling method used, are discussed in detail. Characterisation of the solution structure of hIAPP and its mechanism of oligomerisation is important to understanding its cellular toxicity and its role in disease states, and may ultimately offer new opportunities for therapeutic interventions

HI Fluctuations at Large Redshifts: I--Visibility correlation

We investigate the possibility of probing the large scale structure in the universe at large redshifts by studying fluctuations in the redshifted 1420 MHz emission from the neutral hydrogen (HI) at early epochs. The neutral hydrogen content of the universe is known from absorption studies for z<4.5. The HI distribution is expected to be inhomogeneous in the gravitational instability picture and this inhomogeneity leads to anisotropy in the redshifted HI emission. The best hope of detecting this anisotropy is by using a large low-frequency interferometric instrument like the Giant Meter-Wave Radio Telescope (GMRT). We calculate the visibility correlation function <V_nu(u) V_nu'(u)> at two frequencies nu and nu' of the redshifted HI emission for an interferometric observation. In particular we give numerical results for the two GMRT channels centered around nu =325 and 610 MHz from density inhomogeneity and peculiar velocity of the HI distribution. The visibility correlation is ~10^-9 to 10^-10 Jy^2. We calculate the signal-to-noise for detecting the correlation signal in the presence of system noise and show that the GMRT might detect the signal for integration times ~ 100 hrs. We argue that the measurement of visibility correlation allows optimal use of the uncorrelated nature of the system noise across baselines and frequency channels.Comment: 17 pages, 2 figures, Submitted to JA

Evidence for Filamentarity in the Las Campanas Redshift Survey

We apply Shapefinders, statistical measures of `shape' constructed from two dimensional partial Minkowski functionals, to study the degree of filamentarity in the Las Campanas Redshift Survey (LCRS). In two dimensions, three Minkowski functionals characterise the morphology of an object, they are: its perimeter (L), area (S), and genus. Out of L and S a single dimensionless Shapefinder Statistic, F can be constructed (0 <=F <=1). F acquires extreme values on a circle (F = 0) and a filament (F = 1). Using F, we quantify the extent of filamentarity in the LCRS by comparing our results with a Poisson distribution with similar geometrical properties and having the same selection function as the survey. Our results unambiguously demonstrate that the LCRS displays a high degree of filamentarity both in the Northern and Southern galactic sections a result that is in general agreement with the visual appearance of the catalogue. It is well known that gravitational clustering from Gaussian initial conditions gives rise to the development of non-Gaussianity reflected in the formation of a network-like filamentary structure on supercluster scales. Consequently the fact that the smoothed LCRS catalogue shows properties consistent with those of a Gaussian random field (Colley 1997) whereas the unsmoothed catalogue demonstrates the presence of filamentarity lends strong support to the conjecture that the large scale clustering of galaxies is driven by gravitational instability.Comment: Accepted for publication in Ap

Inheritance of parthenocarpy in gynoecious cucumber (Cucumis sativus L.) cultivar PPC-2

The gynoecious and parthenocarpic inbred line, Pant Parthenocarpic Cucumber-2 (PPC- 2) was crossed with Indian monoecious and non-parthenocarpic cultivar Pusa Uday to develop F1, F2, B1 and B2 to determine the inheritance of parthenocarpy.The crop was grown under insect proof net house of 40 mesh. The pistillate buds were covered using butter paper bags before anthesis to prevent out-crossing.The observations were recorded separately for the development of early parthenocarpic fruits (i.e.1-7th nodes), late parthenocarpy (8th and above nodes) and non-parthenocarpic fruits. In F1 generation, out of 40 plants screened, 2 plants produced parthenocarpic fruits at lower nodes (1-7th nodes), 37 plants produced parthenocarpic fruits at upper nodes (8th and above), whereas,only 1 plant that did not produced any fruit was considered as non-parthenocarpic. The segregation of F2 population and test crosses for parthenocarpic fruit development suggested that parthenocarpy in gynoecious and parthenocarpic cucumber line PPC-2 is under the control of incomplete dominant gene

HI as a Probe of the Large Scale Structure in the Post-Reionization Universe

We model the distribution of neutral Hydrogen (HI hereafter) in the post-reionization universe. This model uses gravity only N-Body simulations and an ansatz to assign HI to dark matter haloes that is consistent with observational constraints and theoretical models. We resolve the smallest haloes that are likely to host HI in the simulations, care is also taken to ensure that any errors due to the finite size of the simulation box are small. We then compute the smoothed one point probability distribution function and the power spectrum of fluctuations in HI. This is compared with other predictions that have been made using different techniques. We highlight the significantly high bias for the HI distribution at small scales. This aspect has not been discussed before. We then discuss the prospects for detection with the MWA, GMRT and the hypothetical MWA5000. The MWA5000 can detect visibility correlations at large angular scales at all redshifts in the post-reionization era. The GMRT can detect visibility correlations at lower redshifts, specifically there is a strong case for a survey at z=1.3. We also discuss prospects for direct detection of rare peaks in the HI distribution using the GMRT. We show that direct detection should be possible with an integration time that is comparable to, or even less than, the time required for a statistical detection. Specifically, it is possible to make a statistical detection of the HI distribution by measuring the visibility correlation, and, direct detection of rare peaks in the HI distribution at z = 1.3 with the GMRT in less than 1000 hours of observations.Comment: 15 pages, 11 figures. Accepted for publication in the MNRAS. This is a merged manuscript also containing material covered in 0908.385