Cardiovascular Disorder Detection with a PSO-Optimized Bi-LSTM Recurrent Neural Network Model

The medical community is facing ever-increasing difficulties in identifying and treating cardiovascular diseases. The World Health Organization (WHO) reports that despite the availability of numerous high-priced medical remedies for persons with heart problems, CVDs continue to be the main cause of mortality globally, accounting for over 21 million deaths annually. When cardiovascular diseases are identified and treated early on, they cause far fewer deaths. Deep learning models have facilitated automated diagnostic methods for early detection of these diseases. Cardiovascular diseases often present insidious symptoms that are difficult to identify in a timely manner. Prompt diagnosis of individuals with CVD and related conditions, such as high blood pressure or high cholesterol, is crucial to initiate appropriate treatment. Recurrent neural networks (RNNs) with gated recurrent units (GRUs) have recently emerged as a more advanced variant, capable of surpassing Long Short-Term Memory (LSTM) models in several applications. When compared to LSTMs, GRUs have the advantages of faster calculation and less memory usage. When it comes to CVD prediction, the bio-inspired Particle Swarm Optimization (PSO) algorithm provides a straightforward method of getting the best possible outcomes with minimal effort. This stochastic optimization method requires neither the gradient nor any differentiated form of the objective function and emulates the behaviour and intelligence of swarms. PSO employs a swarm of agents, called particles, that navigate the search space to find the best prediction type.This study primarily focuses on predicting cardiovascular diseases using effective feature selection and classification methods. For CVD forecasting, we offer a GRU model built on recurrent neural networks and optimized with particle swarms (RNN-GRU-PSO). We find that the proposed model significantly outperforms the state-of-the-art models (98.2% accuracy in predicting cardiovascular diseases) in a head-to-head comparison

The Impact Work-Life Balance Toward Job Satisfaction And Job Performance: Study Of Women Employees Of IT Companies In Bengaluru City, India

An employee's assessment of his work, or how well the organization has matched employee expectations, is known as job satisfaction. Employees that have a healthy work-life balance are more satisfied with their jobs since they can focus well at work and don't have to worry about issues outside of it. Additionally, a healthy work-life balance will improve employee performance, allowing the business to avoid issues with staff retention. The purpose of this study was to investigate the impact of work-life balance on women employees in IT companies job satisfaction and job performance at Bengaluru, India. The study employed a sample consisting of 170 women employees from IT companies located at Bengaluru. Data analysis was done using simple linear regression, and validity and reliability tests were conducted to assess the data's quality. The work-life balance was shown to have an 7.7% impact on job satisfaction and a 3.7% impact on employee retention, according to study data. Offering a nice work environment and facilities to employees is one of the management implications of the research findings that may be put into practice

COMPARATIVE CLINICAL STUDY OF THE HAEMORRHOIDECTOMY AND KSHARASUTRA TRANSFIXATION WITH TWO INCISIONS IN THE MANAGEMENT OF PROLAPSED HAEMORRHOIDS

Kshara-sutra transfixation (KST) is one of the most efficacies and worldwide accepted treatments of hemorrhoids because of its effectiveness and less complication rate. Hemorrhoidectomy (HMD) is the procedure of choice for treatment of grade three and four hemorrhoids, which is a painful method for a relatively benign disease. There are a few studies available analyzing the effectiveness of Ksharasutra transfixation as an initial treatment for grade three and four symptomatic internal hemorrhoids. Arsha (hemorrhoids) is engorgement of the hemorrhoidal venous plexus, characterized by bleeding per rectum, constipation, pain, prolapse and discharge. It is manifested due to improper diet, prolonged standing and faulty habits of defecation causing derangement of Tridosha. The Kshara sutra Transfixation method in Arshas was studied in comparison with hemorrhoidectomy. Kshara sutra trans-fixation with two incision on the bulged mass in Arshas was employed in 15 patients, and 17 patients were dealt with hemorrhoidectomy. The study revealed a better result of the Kshara sutra Transfixation with two incision on the bulged mass group in comparison with hemorrhoidectomy. The observations revealed that maximum advantages like minimum hospital stay, no bleeding during or after operation, no post-operative anal stenosis, a low cost-effective and more acceptable to different categories of people, etc. were recorded in the Kshara sutra-treated group. Statistically, Kshara-sutra Transfixation for Arshas was found to be highly significant (There are significant difference among the PODS with reference to the mean grades. The corresponding F-value is given by 7.486535 which is highly significant at 1% level) and effective management. No adverse effects were noted during the follow-up period

Development and validation of RP HPLC method for determination of metformin and sitagliptin in bulk and pharmaceutical dosage form

A simple and rapid reversed phase-high performance liquid chromatographic method was developed for simultaneous determination of Metformin and Sitagliptin in Tablet Dosage form. The elution was done with a mobile phase of Water: Methanol (60:40) on Intersil-BDS C18 column (250 × 4.6 mm, 5 μm particle size). The wavelength detector was set at 258 nm. Retention times for Metformin and Sitagliptin were around 2.869 min, 3.942 min respectively. The reliability and analytical performance of the proposed HPLC procedure were statistically validated according to the respect of linearity, ranges, precision, accuracy, repeatability, reproducibility, detection and quantification limits. Linear ranges were established between 20-80 μg/mL for both the drug. The LOD and LOQ for Metformin were found to be 0.663, 1.92 and for Sitagliptin were found to be 0.405, 1.228 respectively. The described High Performance Liquid Chromatography method was successfully employed for the analysis of pharmaceutical formulations containing combined dosage for

Endometriosis and Cancer

Endometriosis is a chronic debilitating inflammatory disease of women, with the growth of ectopic endometrium in extrauterine sites like rectovaginal septum, peritoneal surfaces, or ovaries, etc. Though endometriosis is not regarded as a malignant disorder, it does have some features common to malignant disease. They are; local and distant metastasis, invasion and destruction to adjacent structures, unrestricted growth, development of new blood vessels. The association between endometriosis and ovarian, endometrial, and cervical cancers and between endometriosis and extra-ovarian malignancies has been reported in different kinds of literature. Clear cell and endometrioid ovarian carcinomas are presumed to have developed from endometriosis. Ovarian seromucinous borderline tumors, low-grade serous ovarian carcinomas, adenosarcoma, and endometrial stromal sarcomas may also arise from endometriosis. However, it is not very clear whether endometriosis has undergone malignant transformation or simply is found co-existent with cancer. Endometriosis itself may increase a woman’s risk of developing non-Hodgkin’s lymphoma, malignant melanoma, and breast cancer

Doctors on duty: the real-life heroes during pandemic: Your opinion matters!!!

Background: Data for front-line health-care workers, risk of disease is limited so as the resources available. Although inspiring stories on doctors fighting against COVID-19-19 were covered we are still unaware of the challenges at ground level. The present study throws light on it and provides way through towards resolving the issues. Objectives:1. To assess the perceptions of the doctors towards the process of COVID-19-19 crisis management. 2.To identify the challenges and recommend solutions based on their views, suggestions. Methods: A cross sectional study on perception of doctors (94) involved in COVID-19 duty was conducted during July to September 2020, with the help of pre-validated semi-structured questionnaire through online google survey form. The questionnaire had demographic details, views on before, during and after the COVID-19 duty along with 4 open ended questions on their good and bad experiences, problems & suggestions. Descriptive statistics for quantitative & thematic analysis for qualitative data was used. Results: Nonresponse rate was 26%, mean age 27.55 year. Majority were from clinical departments (78%). 42% felt that training was proper, 60% adequate PPE kit, 52.6% were aware of management strategy, 86% stressed,82% found difficulties in communication. 42% were provided proper quarantine facility yet, 58% faced discrimination. Few themes emerged under challenges like lack of resources & training, stress & burnout, for which patient sensitization, refresher training, psychological & administrative support was suggested. Conclusion: Although COVID-19 pandemic has impacted life of doctors in either way, the challenges could easily be tackled by the recommended simple solutions

Multimodal biometric authentication

In the present era of information technology, there is a need to implement authentication and authorization techniques for security of resources. There are number of ways to prove authentication and authorization. But the biometric authentication beats all other techniques. Biometric techniques prove the authenticity or authorization of a human being based on his/her physiological or behavioural traits. Biometrics is a technique by which an individual's identity can be authenticated by applying the physical or behavioural trait. Physical traits like fingerprints, palm, iris etc. are based on the physical characteristics which are generally inherent and unique. Behavioural traits like voice, signature or keystroke dynamics etc. on the other hand, are quantifiable characteristics.They also protect access of resources from unauthorized users. Multimodal biometrics refers to the use of a combination of two or more biometric modalities in a verification / identification system. Identification based on multiple biometrics represents an emerging trend. The most compelling reason to combine different modalities is to improve the recognition rate. This can be done when biometric features of different biometrics are statistically independent. A multimodal biometric identification system aims to fuse two or more physical or behavioural traits. Multimodal biometric system is used in order to improve the accuracy. Multimodal biometric identification system based on iris, palm and fingerprint trait based on fusion logic is proposed. Typically in a multimodal biometric system, each biometric trait processes its information independently. The processed information is combined using curve let transform

Central giant cell granulomas of the jaws: A review of the literature with its emphasis on differential diagnosis on related lesions

Central giant cell granuloma (CGCG) is an uncommon benign intraosseous lesion that occurs almost exclusively in the jaws that has variable clinical behavior and is difficult to predict. The CGCG of the jaws is usually a non-neoplastic bone lesion accounting for fewer than 7% of all benign tumors of the jaws. Before the early 1950s, central giant cell lesions (GCLs) of the jaws were generally diagnosed as giant cell tumor (GCT) usually found in epiphyseal regions of long bones. Giant cell lesions (GCLs) are mandatorily diagnosed in consideration with clinical and radiological features which predicts its aggressive and non-aggressive behavior. The incidence in the general population is very low and patients are generally younger than 30 years. CGCG belongs together with GCT, brown tumor of hyperparathyroidism and cherubism to the so-called GCLs, which can be difficult to distinguish solely by microscopic examination. GCT of the long bones is practically identical with CGCG of the jaws on histopathologic examination and is considered by some authors as a manifestation of the same disease, where age and local factors are responsible for different clinical characteristics. The aim of this review is to focus on general considerations of CGCG along with its management and to differentiate between various centrally placed GCLs which mimic each other histologically and sometimes clinically