33 research outputs found
Scalable Architecture for a Room Temperature Solid-State Quantum Information Processor
The realization of a scalable quantum information processor has emerged over
the past decade as one of the central challenges at the interface of
fundamental science and engineering. Much progress has been made towards this
goal. Indeed, quantum operations have been demonstrated on several trapped ion
qubits, and other solid-state systems are approaching similar levels of
control. Extending these techniques to achieve fault-tolerant operations in
larger systems with more qubits remains an extremely challenging goal, in part,
due to the substantial technical complexity of current implementations. Here,
we propose and analyze an architecture for a scalable, solid-state quantum
information processor capable of operating at or near room temperature. The
architecture is applicable to realistic conditions, which include disorder and
relevant decoherence mechanisms, and includes a hierarchy of control at
successive length scales. Our approach is based upon recent experimental
advances involving Nitrogen-Vacancy color centers in diamond and will provide
fundamental insights into the physics of non-equilibrium many-body quantum
systems. Additionally, the proposed architecture may greatly alleviate the
stringent constraints, currently limiting the realization of scalable quantum
processors.Comment: 15 pages, 6 figure
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18F-Deoxyfluorination of Phenols via Ru Ï-Complexes
The deficiency of robust and practical methods for 18F-radiofluorination is a bottleneck for positron emission tomography (PET) tracer development. Here, we report the first transition-metal-assisted 18F-deoxyfluorination of phenols. The transformation benefits from readily available phenols as starting materials, tolerance of moisture and ambient atmosphere, large substrate scope, and translatability to generate doses appropriate for PET imaging
<sup>18</sup>FâDeoxyfluorination of Phenols via Ru ÏâComplexes
The deficiency of robust and practical
methods for <sup>18</sup>F-radiofluorination is a bottleneck for positron
emission tomography
(PET) tracer development. Here, we report the first transition-metal-assisted <sup>18</sup>F-deoxyfluorination of phenols. The transformation benefits
from readily available phenols as starting materials, tolerance of
moisture and ambient atmosphere, large substrate scope, and translatability
to generate doses appropriate for PET imaging
<sup>18</sup>FâDeoxyfluorination of Phenols via Ru ÏâComplexes
The deficiency of robust and practical
methods for <sup>18</sup>F-radiofluorination is a bottleneck for positron
emission tomography
(PET) tracer development. Here, we report the first transition-metal-assisted <sup>18</sup>F-deoxyfluorination of phenols. The transformation benefits
from readily available phenols as starting materials, tolerance of
moisture and ambient atmosphere, large substrate scope, and translatability
to generate doses appropriate for PET imaging
<sup>18</sup>FâDeoxyfluorination of Phenols via Ru ÏâComplexes
The deficiency of robust and practical
methods for <sup>18</sup>F-radiofluorination is a bottleneck for positron
emission tomography
(PET) tracer development. Here, we report the first transition-metal-assisted <sup>18</sup>F-deoxyfluorination of phenols. The transformation benefits
from readily available phenols as starting materials, tolerance of
moisture and ambient atmosphere, large substrate scope, and translatability
to generate doses appropriate for PET imaging
Translation of HDAC6 PET Imaging Using [F-18]EKZ-001-cGMP Production and Measurement of HDAC6 Target Occupancy in Nonhuman Primates
Histone deacetylase 6 (HDAC6) is a multifunctional cytoplasmic enzyme involved in diverse cellular processes such as intracellular transport and protein quality control. Inhibition of HDAC6 can alleviate defects in cell and rodent models of certain diseases, particularly neurodegenerative disorders, including Alzheimer's disease and amyotrophic lateral sclerosis. However, while HDAC6 represents a potentially powerful therapeutic target, development of effective brain-penetrant HDAC6 inhibitors remains challenging. Recently, [18F]EKZ-001 ([18F]Bavarostat), a brain-penetrant positron emission tomography (PET) radioligand with high affinity and selectivity toward HDAC6, was developed and evaluated preclinically for its ability to bind HDAC6. Herein, we describe the efficient and robust fully automated current Good Manufacturing Practices (cGMP) compliant production method. [18F]EKZ-001 quantification methods were validated in nonhuman primates (NHP) using full kinetic modeling, and [18F]EKZ-001 PET was applied to compare dose-occupancy relationships between two HDAC6 inhibitors, EKZ-317 and ACY-775. [18F]EKZ-001 is cGMP produced with an average decay-corrected radiochemical yield of 14% and an average molar activity of 204 GBq/ÎŒmol. We demonstrate that a two-tissue compartmental model and Logan graphical analysis are appropriate for [18F]EKZ-001 PET quantification in NHP brain. Blocking studies show that the novel compound EKZ-317 achieves higher target occupancy than ACY-775. This work supports the translation of [18F]EKZ-001 PET for first-in-human studies.status: publishe