Heterologous booster COVID-19 vaccination elicited potent immune responses in HCWs

The objective of our study was to evaluate the antibody responses of health care workers (HCWs) who were vaccinated with booster dose BNT162b2 6 months after 2 doses of the CoronoVac vaccine. The study included 318 HCWs vaccinated with inactive CoronaVac SARS-CoV-2 vaccine in 2 doses. Anti-spike/RBD IgG levels were measured immediately before and 1 month after the booster dose. In the sixth month after CoronaVac vaccination, the median of antibody levels of 1212.02 AU/ML, while it was 9283 AU/mL after BNT162b2 vaccination. IgG antibody titers of over 1050 AU/mL (which is equivalent to 1:80 dilution in the plaque reduction neutralization test) were detected in HCWs 15.09% and 97.8%, respectively. Our results showed that antibody titers increased 8-fold after the booster dose. We believe that the administration of the mRNA vaccine as a booster dose can provide more effective protection against COVID-19 infection, especially in individuals with risk factors.IU-Cerrahpaşa Scientific Research Projects Uni

Waning immunity to inactive SARS-CoV-2 vaccine in healthcare workers: Booster required

Aims Despite high vaccination rates, increasing case numbers continue to be reported with the identification of new variants of concern, and the issue of durability of the vaccine-induced immune response remains hot topic. Real-life data regarding time-dependent immunogenicity of inactivated COVID-19 vaccines are scarce. We aimed to investigate the changes in the antibody at the different times after the second dose of the CoronaVac vaccine. Methods The study included 175 HCWs vaccinated with inactive CoronaVac (Sinovac Life Sciences, China) SARS-CoV-2 vaccine in two doses. Anti-spike/RBD IgG levels were measured first, third, and sixth months after the second dose. Chemiluminescent microparticle immunoassay (IgG II Quant test, Abbott, USA), which is 100% compatible with plaque reduction neutralization test, was used. Results Mean age of the participants was 38 +/- 11.23 years (range between 22 and 66) of whom 119 (63.9%) were female, and 56 (32%) were male. Dramatic reductions were demonstrated in median antibody levels particularly in the infection-naive group, comprising 138 HCWs compared to those with prior history of COVID-19 infection (n = 37) (p < 0.001). There was no difference between the two groups in terms of age, gender, blood groups, BMI, and comorbid diseases. Conclusions While antibody positivity remained above 90% in the 6th month after two doses of inactivated vaccine in HCWs, the median titers of neutralizing antibodies decreased rapidly. The decrease was more rapid and significant in those with no history of prior COVID-19 infection. In this critical phase of the pandemic, where we are facing the dominance of the Omicron variant after Delta, booster doses have become vital.IU-Cerrahpasa Scientific Research Projects Uni

Attitudes of university students towards love and the relationship of relation satisfaction with personality traits

Bu araştırmanın iki temel amacı vardır. Birincisi üniversite öğrencilerinin kişilik özellikleri ve aşka ilişkin tutumlarının, romantik ilişki doyumlarını yordayıp yordamadığını incelemektir. İkincisi ise üniversite öğrencilerinin aşka ilişkin tutumlarının ve romantik ilişki doyumlarının, cinsiyete, ilişki sayısına ve ilişki süresine göre farklılaşıp farklılaşmadığını incelemektir. Araştırmaya, 2009-2010 eğitim yılında Gazi Üniversitesi Gazi Eğitim Fakültesinin çeşitli bölümlerine devam eden ve romantik ilişki yaşayan, 250 kız, 87 erkek, 337 öğrenci katılmıştır. Araştırmada, verileri toplamak için, Aşka İlişkin Tutumlar Ölçeği (Kısa Form) , Sıfatlara Dayalı Kişilik Testi, İlişki Doyumu Ölçeği ve kişisel bilgi formu kullanılmıştır. Veri analizinde SPSS 17.0 programı kullanılmış ve t testi, tek yönlü varyans analizi ve çoklu regresyon analizi yapılmıştır. 1. Üniversite öğrencilerinin kişilik özelliklerinden Dışadönüklük ile Yumuşak Başlılık, Sorumluluk, Nevrotizm, Deneyime Açıklık kişilik özellikleri, birlikte Romantik İlişki Doyumuna ilişkin varyansın %11'ini açıklamıştır. Yordayıcı değişkenlerden deneyime açıklık romantik ilişki doyumunun en güçlü yordayıcısı olurken bunu dışadönüklük kişilik özelliği izlemiştir. 2. Üniversite öğrencilerinin aşk tutumlarından, Özgeci Aşk, Arkadaşça Aşk, Tutkulu Aşk, Mantıklı Aşk, Oyun Gibi Aşk, Sahiplenici Aşk tutumları, Romantik İlişki Doyumuna ilişkin varyansın %58'ini açıklamıştır. Yordayıcı değişkenlerden tutkulu aşk romantik ilişki doyumunun en güçlü yordayıcısı olurken bunu sırasıyla özgeci aşk, sahiplenici aşk ve oyun gibi aşk izlemiştir. 3. Üniversite öğrencilerinin aşka ilişkin tutumları cinsiyete göre anlamlı farklılık göstermiştir. Erkeklerin kadınlara göre özgeci ve oyun gibi aşk tutumları puanlarının daha yüksek olduğu ve kadınların erkeklere göre mantıklı ve arkadaşça aşk tutumu puanlarının daha yüksek olduğu bulunmuştur. 4. Üniversite öğrencilerinin romantik ilişki doyumları cinsiyete ve ilişki sayısına göre anlamlı farklılık göstermemiştir. 5. Üniversite öğrencilerinin aşka ilişkin tutumları ilişki sayısına ve ilişki süresine göre anlamlı farklılık göstermiştir. Üniversite öğrencilerinin yaşanılan ilişki sayısı arttıkça oyun gibi aşk tutumu puanlarının yükseldiği, arkadaşça aşk tutumu puanlarının ise düştüğü bulunmuştur. Üniversite öğrencilerinin yaşanılan ilişki süresi uzadıkça tutkulu aşk tutumu puanlarının yükseldiği bulunmuştur 6. Üniversite öğrencilerinin romantik ilişki doyumları ilişki süresine göre anlamlı farklılık göstermiştir. Üniversite öğrencilerinin ilişki süresi arttıkça romantik ilişki doyumlarının yükseldiği bulunmuştur.There are two main purposes of this study. First purpose is to analyze whether romantic relationship satisfaction of the university students can be predicted from their personality traits and attitudes towards love or not. Second purpose is to analyze whether the attitudes towards love and romantic relationship satisfaction of the university students differantiate according to gender, number of romantic relationship and romantic relationship time duration or not. For this purpose, 250 female and 87 male, all in romantic relationship of totally 337 students from different departments of Gazi University Education Faculty in 2009-2010 education year participated in the study. Love Attitudes Scale (short form) , Adjective Based Personality Scale (ABPT) , Relationship Assessment Scala and Personal Information Form were used to provide the data. To analyze the data SPSS 17.0 programme was used, and the t test,single variable variance analysis and multiple regression analysis were done. 1. Extraversion, Agreeableness, Conscientiousness, Neuroticzm and Openess personality traits of the university students all together explained 11% of the variance related to romantic relationship satisfaction. Opennes to experience personality trait was the strongest predictive variable of relationship satisfaction, which was followed by extraversion personality trait. 2. University students' attitudes towards love which were Agape , Storge, Eros, Pragma, Ludus, Mania love attitudes explained 58% of the variance related to romantic relationship satisfaction. Eros was the strongest predictive variable of romantic relationship satisfaction, which was followed by agape, mania and ludus respectively. 3. University students' attitudes towards love showed significant difference according to gender. It was found that males' agape and ludus scores were higher than females' scores and females' pragma and storge scores were higher than males' scores. 4. University students' romantic relationship satisfaction didn't show any significant difference according to gender and relationship number. 5. University students' attitudes towards love showed significant difference according to number of romantic relationship and romantic relationship time duration. As the number of romantic relationship increased ludus scores increased whereas storge scores decreased. It was found that university students' increasing time duration of romantic relationship means increasing eros scores. 6. University students romantic relationship satisfaction showed significant difference according to romantic relationship time duration. As the romantic relationship time duration of university increased, it was found that romantic relationship satisfaction also increased

The Effect of Gastrointestinal Symptoms on Hopelessness and Depression in Patients with Irritable Bowel Syndrome

Amaç: Bu çalışma irritable bağırsak sendromu olan hastalarda gastrointestinal semptomların depresyon ve umutsuzluk düzeyine etkisini belirlemek amacıyla planlanmıştır. Gereç ve Yöntem: Çalışmanın yapıldığı üniversite hastanesinin gastroenteroloji polikliniğine IBS tanısı almış günde ortalama 3 hasta başvurmaktadır. Araştırmanın evrenini 01.03.2017-05.08.2017?tarihleri arasında polikliniğe başvuran 314 hasta, örneklemini ise 18 yaş ve üzeri, IBS tanısı almış, iletişim sorunu olmayan ve araştırmaya katılmayı kabul eden 209 birey oluşturmuştur. Veriler hastaların sosyodemografik özelliklerini içeren Hasta Tanıtım Formu, Gastrointestinal Semptom Değerlendirme Ölçeği(GSDÖ, Beck Depresyon Ölçeği(BDÖ) ve Beck Umutsuzluk Ölçeği(BUÖ) ile toplanmıştır. Verilerin değerlendirilmesinde yüzdelik, t testi, kikare testi, ANOVA ve pearson korelasyon testi kullanılmıştır. Bulgular: Yaş ortalaması 40.69±14.0 olan hastaların, ortalama hastalık süresi 6.0±1.3 yıldır. Hastaların GSDÖ’nden aldıkları toplam puan ortalaması 52.0±1.65 olup, orta düzeyde semptom şiddetine sahip oldukları görülmüştür.. BUÖ puan ortalaması 8.0±3.1, BDS puan ortalaması 10.0±6.9 olup, hafif düzeyde umutsuzluk ve depresyon belirtisine sahip olduğu görülmüştür. GSDÖ alt boyutlarından karın ağrısı, reflü, hazımsızlık, diyare ve GSDÖ toplam puanıyla BUÖ ve BDÖ arasında anlamlı bir ilişki saptanmazken, konstipasyon alt boyut puanıyla BUÖ arasında pozitif yönde orta düzeyde bir ilişki saptanmıştır. Benzer şekilde BDÖ ile konstipasyon alt boyut puanıyla pozitif yönde güçlü düzeyde bir ilişki saptanmıştır. Sonuç: Konstipasyon ile depresyon ve umutsuzluk arasında güçlü ve orta düzeyde bir ilişki saptanmıştır. Özellikle konstipasyonu olan hastaların depresyon ve umutsuzluk düzeyi açısından değerlendirilmesi gerekmektedir.Objective: The present study aimed to determine the effect of gastrointestinal symptoms on hopelessness and depression in patients with irritable bowel syndrome (IBS). Material and Methods: An average of 3 patients were admitted to the gastroenterology polyclinic of the university hospital where they worked. The universe of the study included 314 patients who presented at the clinic between March, 1st 2017 and August, 5th 2017, while the sample consisted of 209 patients who were aged 18 and older, were diagnosed with IBS, had no barriers to communication, and agreed to participate in the study. Data was collected using the Patient Identification Form containing the socio-demographic characteristics, the Gastrointestinal Symptom Rating Scale (GSRS), the Beck Depression Inventory (BDI), and the Beck Hopelessness Scale (BHS). Data was analyzed using percentiles, t-test, chi-square test, ANOVA, Pearson correlation, and regression analysis. Results: Mean age of the patients was 40.69±14.0, while mean disease duration was 6.0±1.3 years. Mean GSRS score was 52.0±1.65, indicating moderate symptom severity. Mean BHS score was 8.0±3.1 and mean BDI score was 10.0±6.9, indicating mild hopelessness and depression. The abdominal pain, reflux, indigestion, and diarrhea subscale scores of the GSRS and the total GSRS score were not significantly correlated with the BHS and BDI scores (p<0.05); while the constipation subscale score of the GSRS had a positive and moderate correlation with the BHS score (p<0.0001; r=0.24). The constipation subscale score of the GSRS also had a positive and strong correlation with the BDI score (p<0.0001; r=0.41). Conclusion: Constipation was strongly and moderately correlated with depression and hopelessness. Patients with constipation, in particular, should be screened for depression and hopelessness. Keywords: Irritable bowel syndrome, gastrointestinal symptom, depression, hopelessnes

Waning effectiveness of CoronaVac in real life: A retrospective cohort study in health care workers

Background: Real-world studies showed varying levels of effectiveness of CoronaVac vaccine against COVID-19 disease. This study aimed to assess the association between the vaccination with CoronaVac and the COVID-19 infections among the health care workers in a university hospital and to determine the vaccine effectiveness against COVID-19 in a period when alpha variant was dominant.Methods: This retrospective cohort study was conducted in a university hospital in Istanbul, Turkey employs 4067 health care workers. The follow-up period was defined as starting 14 days after receiving the second dose for fully vaccinated group. Health care workers were censored when have a positive PCR test result or at the end of the study. Unvaccinated health care workers were censored if they receive any COVID-19 vaccine doses. The incidence rate ratio and Cox regression were used to estimate the unadjusted and adjusted effectiveness of the vaccine

Effectiveness of the BNT162b2 and the CoronaVac vaccines and boosters in healthcare workers

ABSTRACTThe evidence on the waning protection of COVID-19 vaccines has been reviewed by the World Health Organization and has led to consideration of the need for booster doses. This study aimed to evaluate vaccine effectiveness against COVID-19, and the COVID-19 infections among healthcare workers who received various types (inactive or m-RNA) and doses (2 to 4 doses) of the COVID-19 vaccine. The study was conducted with a total of 3,009 healthcare workers between August 1 and November 30, 2021 at a university hospital. Six different vaccination statuses were evaluated in the study. The effectiveness for COVID-19 infection, after adjusting for age, sex, and position, was highest in those who received two doses of CoronaVac and two doses of BNT162b2 (89.3%, 95% CI 72.2–95.9%) and was lowest in those who received two doses of CoronaVac (29%, 95% CI − 8–53%). The adjusted effectiveness of two doses of CoronaVac for COVID-19 infection was not significant (21.0%, 95% CI − 20.7–48.3%) but increased significantly with a booster dose of CoronaVac or BNT162b2. One or two doses of the BNT162b2 booster demonstrated higher effectiveness in comparison to a single dose of the CoronaVac booster. These results indicate the need for a booster dose, and heterologous boosting with BNT162b2 may be a better option for higher effectiveness for those who received two doses of CoronaVac. Future studies should evaluate the need for further booster doses and their long-term effects

COVID-19 Vaccine Hesitancy in Healthcare Personnel: A University Hospital Experience

Healthcare workers are among risk groups in the COVID-19. Even if they are not infected with the disease, they witness the effects of the pandemic. The aim of the study is to determine the factors affecting COVID-19 vaccination status and reasons for vaccine hesitancy of healthcare personnel in our hospital. Firstly, the vaccination status and demographic characteristics of all healthcare personnel was evaluated. After that, a survey was applied to 408 vaccinated and 297 nonvaccinated personnel. Within the first month after the beginning of vaccination, 66% of 3937 healthcare personnel received a COVID-19 vaccine. The number of vaccinated personnel was higher among doctors, master graduates or higher educational levels and basic science-laboratory unit workers. In the surveyed group, being under the age of 50 (OR:1.85), being nondoctor healthcare personnel (nurse/midwife OR:1.78, administrative personnel OR:3.42, patient attendant/cleaning staff OR:4.11, security guard/other OR:2.96), having had the disease before (OR:2.36), not having the flu vaccine (OR:3.24) and hesitancy about other vaccines (OR:6.61) were found to be independent risk factors for not having a COVID-19 vaccine or having it late. The three most common reasons for not getting vaccinated were doubt on the efficacy of the vaccine, distrust of its content, and fear of side effects. Taking steps by considering the main factors of hesitancy among healthcare personnel will increase the vaccine acceptance

Homologous or heterologous COVID-19 vaccine schemes: Comparison of immune responses and side effects

Real-life data are needed regarding the appropriate time and selection of vaccination strategies, homologous or heterologous. We aimed to compare neutralizing antibody levels and side effects in different vaccination schemes. The study included 310 Health Care Workers (HCWs) vaccinated with 5 different schemes. Antispike/RBD IgG levels were measured between 28 and 60 days after the last dose. Side effects in participants were recorded, and pharmacovigilance records were reviewed from the outpatient vaccine clinic. Mean age of the participants was 38 ± 11 years of whom 226 (72.9%) were female, and 84 (27.1%) were male. After booster doses, increasing antibody levels were detected in all groups. Mean antibody levels were detected to be statistically lower in 3 doses of inactivated vaccines group. The side effects were no significant difference between groups. Booster dose administration with mRNA vaccines stands out as the most accurate strategy for those at risk of contracting severe COVID-19 and HCWs caring for this population.IU-Cerrahpaşa Scientific Research Projects Uni

Waning immunity to inactive SARS-CoV-2 vaccine in healthcare workers: booster required

Aims Despite high vaccination rates, increasing case numbers continue to be reported with the identification of new variants of concern, and the issue of durability of the vaccine-induced immune response remains hot topic. Real-life data regarding time-dependent immunogenicity of inactivated COVID-19 vaccines are scarce. We aimed to investigate the changes in the antibody at the different times after the second dose of the CoronaVac vaccine. Methods The study included 175 HCWs vaccinated with inactive CoronaVac (Sinovac Life Sciences, China) SARS-CoV-2 vaccine in two doses. Anti-spike/RBD IgG levels were measured first, third, and sixth months after the second dose. Chemiluminescent microparticle immunoassay (IgG II Quant test, Abbott, USA), which is 100% compatible with plaque reduction neutralization test, was used. Results Mean age of the participants was 38 +/- 11.23 years (range between 22 and 66) of whom 119 (63.9%) were female, and 56 (32%) were male. Dramatic reductions were demonstrated in median antibody levels particularly in the infection-naive group, comprising 138 HCWs compared to those with prior history of COVID-19 infection (n = 37) (p < 0.001). There was no difference between the two groups in terms of age, gender, blood groups, BMI, and comorbid diseases. Conclusions While antibody positivity remained above 90% in the 6th month after two doses of inactivated vaccine in HCWs, the median titers of neutralizing antibodies decreased rapidly. The decrease was more rapid and significant in those with no history of prior COVID-19 infection. In this critical phase of the pandemic, where we are facing the dominance of the Omicron variant after Delta, booster doses have become vital

Inactive SARS-CoV-2 vaccine generates high antibody responses in healthcare workers with and without prior infection

Background and Objectives: Healthcare workers (HCWs) were among the first groups to be vaccinated in Turkey. The data to be obtained by the vaccination of HCWs would guide wide spread vaccination programs