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Bioactivity and antibacterial behaviors of nanostructured lithium-doped hydroxyapatite for bone scaffold application
The material for bone scaffold replacement should be biocompatible and antibacterial to prevent scaffold-associated infection. We biofunctionalized the hydroxyapatite (HA) properties by doping it with lithium (Li). The HA and 4 Li-doped HA (0.5, 1.0, 2.0, 4.0 wt.%) samples were investigated to find the most suitable Li content for both aspects. The synthesized nanoparticles, by the mechanical alloying method, were cold-pressed uniaxially and then sintered for 2 h at 1250 °C. Characterization using field-emission scanning electron microscopy (FE-SEM) revealed particle sizes in the range of 60 to 120 nm. The XRD analysis proved the formation of HA and Li-doped HA nanoparticles with crystal sizes ranging from 59 to 89 nm. The bioactivity of samples was investigated in simulated body fluid (SBF), and the growth of apatite formed on surfaces was evaluated using SEM and EDS. Cellular behavior was estimated by MG63 osteoblast-like cells. The results of apatite growth and cell analysis showed that 1.0 wt.% Li doping was optimal to maximize the bioactivity of HA. Antibacterial characteristics against Escherichia coli (E. coli) and Staphylococcus aureus (S. aureus) were performed by colony-forming unit (CFU) tests. The results showed that Li in the structure of HA increases its antibacterial properties. HA biofunctionalized by Li doping can be considered a suitable option for the fabrication of bone scaffolds due to its antibacterial and unique bioactivity properties
A view on organic binder effects on technical properties of ceramic Raschig rings
Organic binders such as polyvinyl alcohol, carboxymethyl cellulose and Arabic gum are widely used to control the technological parameters required for green and sintered ceramic bodies. An industrial ceramic Raschig ring composed of kaolinite, illite, pyrophillite and quartz minerals was separately mixed with different content of above binders and formed by extrusion process in the shape of Raschig ring. The dried specimens were sintered at 1270°C and the physicalmechanical characteristics of sintered bodies were evaluated by measuring bulk density, total and closed porosities and compressive strength. In addition, the effect of binder type and amount on reliability of ceramic Raschig rings was evaluated by computing Weibull modulus. The obtained data exhibited optimum strength and reliability in presence 0,75 wt.% carboxymethyl cellulose.<br><br>Los compuestos orgánicos tales como el alcohol polivinilico, la carboxilmetil celulosa y la goma Arábica son ampliamente utilizados para conseguir aglomerar los polvos cerámicos en verde. Se han preparado, por el método de extrusión, materiales cerámicos en forma de anillos Raschig a partir de minerales (caolina, illita, pirofilita y cuarzo) mezclados con diferentes contenidos de alguno de los aglomerantes mencionados. Los anillos, una vez secos, fueron sinterizados a 1270 ºC y caracterizados físicamente; se midieron la densidad, porosidad total y cerrada y las propiedades mecánicas. Asimismo se evaluó el efecto del tipo y cantidad de aglomerante empleado en el procesamiento de los anillos calculando el módulo de Weibull para los distintos anillos. Los datos obtenidos indican que la mayor resistencia mecánica se presenta cuando se ha utilizado 0,75% en peso de carboxilmetil celulosa como ligante
Antibacterial and cellular behaviors of novel zinc-doped hydroxyapatite/graphene nanocomposite for bone tissue engineering
10.3390/ijms22179564International Journal of Molecular Sciences2217956