Goddess, King, and Grail: Aspects of Sovereignty within the Early Medieval Heroic Tradition of the British Isles

When studying the heroic tales and epics of medieval cultures, more questions about their origins and influences remain than answers. The search for sources for a single work, Beowulf, for example, can and has been examined within Germanic, Brittanic, Norse, and even Irish traditions. Scores of sources, parallels, and analogues have been found and analyzed, but so many possibilities may only serve to obfuscate the actual origins of the Beowulf poet\u27s myriad influences. However, the search for analogous works can build a stronger sense of context for certain motifs and greater themes within a large number of similar texts. Thus, repetitive elements, especially of the mythological sort, can provide scholars with a glimpse of shared mythologies between otherwise very different cultures. The problem is that so many of these memes are hidden by centuries of redactions and revisions by scribes who had no firsthand knowledge of the original composer\u27s cultural identity. The few shared elements that survive the transition from oral to written literacy are among the strongest arguments for a shared Celtic mythology that existed before the Christians or Anglo-Saxons. The surprising frequency in which these memes appear in Irish, Anglo, Germanic, and Welsh texts would seem to indicate that some motifs more accurately reflect the earlier Celtic mythology than the more whitewashed elements found in later manuscripts. Two particular motifs appear regularly within the context of the great heroic tales of medieval Britain, Ireland, and Wales: the goddess of sovereignty and fertility, and the magical properties of a certain cauldron, sometimes known as the Grail

Covid lessons on information literacy instruction

This paper explores howthe COVID pandemicand other geopolitical eventshighlighted the need for information literacy(IL)instruction in universities. Weargue that teaching students to understand how corporatized information resources exist for profit is a cornerstone of helping transform them into responsible digital citizens and information-literate learners in the world. In this study, weexplain misinformation and disinformation, then explore how our current information systemspreads and nurtures this “disruptive communication” (Bennett &Livingston,2021). Next, weprovideexamples of how academic librariesresponded to the pandemic and sought to combat disruptive communication. This is contrasted with the catastrophic consequences witnessed worldwide due to the spread of misinformation and disinformation. To underscore the paramount importance of this, weprovide examples of the outcomes of mis-/disinformation campaigns—including an attempted coup d’état.Because we have witnessed the devastation that a lack of IL can engender, it is evident that it should therefore be included in all university courses.weprovide a handful ofsuggestionsfor instructors, along with teaching resourcesand other suggestions for further research.Este estudo explora como a pandemia da COVID e outros eventos geopolíticos destacaram a necessidade ensinar literacia informacional (IL) nas universidades. Neste estudo, defendemos que ensinar os estudantes que os de recursos de informação corporativos têm fins lucrativos é uma pedra angular para os ajudar a transformar em cidadãos digitais responsáveis e com literacia informacional. Neste estudo, explica-se o que é informação errada e desinformação e explora-se como o nosso sistema de informação atual dissimina e alimenta esta "comunicação confusa" (Bennett & Livingston, 2021). A seguir, dão-se exemplos de como as bibliotecas das universidades responderam à pandemia e procuraram combater a comunicação confusa. Contrasta-se esta prática com as consequências catastróficas testemunhadas em todo o mundo, devido à disseminação de informação errada e desinformação. Para sublinhar a importância deste facto, dão-se exemplos de resultados de campanhas de informação errada e de desinformação -incluindo uma tentativa de coup d’état. As consequências negativas que testemunhámos devido à falta de IL leva-nos a sugerir que esta competência deve ser incluída em todos os cursos universitários, pelo que apresento algumas sugestões para professores, juntamente com recursos didáticos e outras sugestões para mais investigação.info:eu-repo/semantics/publishedVersio

Quality Control in Induction Hardness and Computer Numerical Control Grinding

The purpose of this research was to conduct an investigation into the improvement of quality of the products produced by the Cooper Hand Tools Division of Cooper Industries and make recommendations where applicable. Two processes were chosen: induction hardness and computer numerical control (CNC) grinding. The Jaw 0010C and the Jaw 311C were two products involved in the induction hardness process that were under experimentation. In the CNC grinding area, the following products\u27 quality were studied: 166L shear (top blade only), 766 shear ( bottom blade only), and the IDS-SB shear (top blade only). Using statistical procedures and designs, some recommendations and observations were recorded and reported to Cooper Hand Tools. A full explanation of the two topics follows, along with a summary of each experiment and its results

A study of permissive loans in Red Cross cases, July 1950-June 1951, at Boston Metropolitan Chapter.

Thesis (M.S.)--Boston Universit

Vocational Evaluation of the Adult Deaf in a Comprehensive Rehabilitation Facility

Non

Old English Manuscripts in the Early Age of Print: Matthew Parker and his Scribes

Covering the first dedicated program in the study of and publication of Anglo-Saxon texts, my dissertation examines the sixteenth-century origins of medieval studies as an academic discipline. By placing recent scholarship on media, materiality, cognition, and intellectual history in conversation with traditional paleographical methods on medieval and renaissance manuscript culture, I argue for a new way of understanding how early modern scholars studied and presented the medieval past. I take as my focus a corpus of emulative Anglo-Saxon manuscript transcriptions produced under Elizabethan Archbishop Matthew Parker. Equal parts facsimile and edition, these transcriptions are a unique example of early modern scholars navigating the often competing demands of late sixteenth century manuscript and print culture. This dissertation is, in part, an attempt to catalogue and document the extent of Parkerian Anglo-Saxon manuscript transcriptions. Temporally displaced from their source texts, Parker and his scribes directly modified many of the medieval manuscripts they recovered by editing, rebinding, cropping, and annotating them according to their own interpretive desires and publication needs. These transcriptions place Parker’s early modern scribes into the textual community of early medieval scribal culture, but their printed manuscript editions are an attempt to bring medieval documents into contemporary discourse. They developed new typefaces modeled on manuscript exemplars and attempted to reframe the printed version of a medieval text as an authoritative surrogate for the manuscript original—image and text worked together to craft new meanings. By examining the material scribal practices of Parker’s household, considering the choices made by Parker in preserving texts through both print and manuscript media, and rethinking how early modern antiquaries approached scholarship, I argue that his transcribed manuscripts offer insights into the early modern origins of medieval literary scholarship

CORSSTOL: Cylinder Optimization of Rings, Skin, and Stringers with Tolerance sensitivity

Cylinder Optimization of Rings, Skin, and Stringers with Tolerance (CORSSTOL) sensitivity is a design optimization program incorporating a method to examine the effects of user-provided manufacturing tolerances on weight and failure. CORSSTOL gives designers a tool to determine tolerances based on need. This is a decisive way to choose the best design among several manufacturing methods with differing capabilities and costs. CORSSTOL initially optimizes a stringer-stiffened cylinder for weight without tolerances. The skin and stringer geometry are varied, subject to stress and buckling constraints. Then the same analysis and optimization routines are used to minimize the maximum material condition weight subject to the least favorable combination of tolerances. The adjusted optimum dimensions are provided with the weight and constraint sensitivities of each design variable. The designer can immediately identify critical tolerances. The safety of parts made out of tolerance can also be determined. During design and development of weight-critical systems, design/analysis tools that provide product-oriented results are of vital significance. The development of this program and methodology provides designers with an effective cost- and weight-saving design tool. The tolerance sensitivity method can be applied to any system defined by a set of deterministic equations

3D-Printed Energy-Absorbing Polymer Structures for Reducing Injury Risk from Overhead Impacts to Hard Hats

Project of Merit Winner Struck-by accidents (i.e., being hit by a falling object) are a leading cause of traumatic brain injuries (TBIs) in the construction industry. While hardhats are the conventional means of head protection in this setting, their overall design has not appreciably changed in decades. In this project, a commercially available hardhat was augmented by creating a compliant cantilever on the superior surface supported by a 3D-printed block (10 x 10 x 50mm, with hexagonal lattice infill) to serve as a sacrificial energy-absorbing structure. The lattices were created using three polymer materials (PLA, ABS, and High-Impact Polystyrene (HIPS)) at four levels of porosity (0%, 32.5%, 56%, and 69.3%). A Hybrid III head/neck assembly was fitted with each hardhat design, and a vertical impact test was conducted using a 1.8-kg steel impactor dropped from 1.83 m. The maximum acceleration and head injury criterion (HIC) were calculated from the impact data for each test. Analysis of variance (ANOVA) revealed that HIC was significantly reduced for all lattices with 56% porosity (

TRANSCRIPTIONAL ADAPTATION TO TARGETED INHIBITORS VIA BET BROMODOMAIN PROTEINS IN TRIPLE-NEGATIVE BREAST CANCER

Targeted kinase inhibitors have displayed limited efficacy in treating breast cancer due to the ability of tumor cells to upregulate bypass signaling networks in response to treatment. Triple-negative breast cancers (TNBCs) often present with dysregulation of the BRaf-MEK-ERK pathway, making them sensitive to MEK inhibitor (MEKi) treatment. Despite initial clinical responses, drug resistance often develops involving non-genomic adaptive bypass mechanisms. Inhibition of MEK1/2 by trametinib in TNBC patients induced dramatic transcriptional responses, including upregulation of receptor tyrosine kinases (RTKs) when comparing tumor samples before and after one week of treatment. In preclinical models, MEK inhibition induced genome-wide enhancer formation involving the seeding of BRD4, MED1, H3K27 acetylation and p300 that drove transcriptional adaptation. Inhibition of P-TEFb associated proteins arrested enhancer seeding and RTK upregulation. BRD4 bromodomain inhibitors or RNAi knockdown of BRD4 overcame trametinib resistance, producing sustained growth inhibition in cells, xenografts and syngeneic mouse TNBC models. These data highlight pharmacological targeting of P-TEFb members, including BET bromodomains, in conjunction with MEK inhibition as an effective strategy to durably inhibit epigenomic remodeling required for adaptive resistance. The ability of BET bromodomain inhibitors to block the adaptive response of TNBC to MEKi made us question whether BET bromodomain inhibitors could block adaptation to targeted inhibition of additional kinases or signaling pathways. Screening of an inhibitor library targeting kinases and epigenetic regulators identified a series of molecules which displayed anti-proliferative synergy with BET bromodomain inhibitors (JQ1, OTX015) in TNBC. GSK2801, an inhibitor of BAZ2A/B bromodomains, of the imitation switch chromatin remodeling complexes, and BRD9, of the SWI/SNF complex, demonstrated unique synergy independent of BRD4 control of P-TEFb-mediated pause-release of RNA polymerase II. GSK2801, or RNAi knockdown of BAZ2A/B, in combination with JQ1 selectively displaced BRD2 at promoters/enhancers of ETS-regulated genes. Additional displacement of BRD2 from ribosomal DNA in the nucleolus coincided with decreased 45S rRNA, revealing a function of BRD2 in regulating RNA polymerase I transcription. In 2D cultures, enhanced displacement of BRD2 from chromatin by combination drug treatment induced senescence. In spheroid cultures, combination treatment induced cleaved caspase-3 characteristic of apoptosis in tumor cells but not co-cultured mammary fibroblasts. Thus, GSK2801 blocks BRD2-driven transcription in combination with BET inhibition and induces apoptosis of TNBC. Cumulatively, the data presented in this thesis provides a series of synergistic drug combinations which effectively inhibit growth and survival of TNBC in combination with targeted inhibitors via inhibition of P-TEFb transcriptional elongation by BRD4, or regulation of ETS target genes and rRNA transcription by BRD2.Doctor of Philosoph

Uncertainty Quantification in Emission Quantitative Imaging

Imaging detectors have potential to improve the reliability of plutonium holdup measurements. Holdup measurement is a significant challenge for nuclear safeguards and criticality safety. To infer holdup mass today, inspectors must combine data from counting (non-imaging) detectors with spatial measurements, process knowledge, and survey estimates. This process results in limited certainty about the holdup mass. Imaging detectors provide more information about the spatial distribution of the source, increasing certainty. In this dissertation we focus on the emission quantitative imaging problem using a fast-neutron coded aperture detector. We seek a reliable way to infer the total intensity of a neutron source with an unknown spatial distribution. The source intensity can be combined with other measurements to infer the holdup mass. To do this we first create and validate a model of the imager. This model solves the forward problem of estimating data given a known source distribution. We use cross-validation to show that the model reliably predicts new measurements (with predictable residuals). We then demonstrate a non-Bayesian approach to process new imager data. The approach solves the inverse problem of inferring source intensity, given various sources of information (imager data, physical constraints) and uncertainty (measurement noise, modeling error, absence of information, etc). Bayesian approaches are also considered, but preliminary findings indicate the need for advanced Markov chain algorithms beyond the scope of this dissertation. The non-Bayesian results reliably provide confidence intervals for medium-scale problems, as demonstrated using a blind-inspector measurement. However, the confidence interval is quite large, due chiefly to modeling error.PHDNuclear Engineering & Radiological SciencesUniversity of Michigan, Horace H. Rackham School of Graduate Studieshttps://deepblue.lib.umich.edu/bitstream/2027.42/136929/1/ambevill_1.pd