5,321 research outputs found

    Identifying empirically supported treatments: What if we didn't?

    Get PDF

    The Clustering Of Galaxies Around Radio-Loud AGNs

    Full text link
    We examine the hypothesis that mergers and close encounters between galaxies can fuel AGNs by increasing the rate at which gas accretes towards the central black hole. We compare the clustering of galaxies around radio-loud AGNs with the clustering around a population of radio-quiet galaxies with similar masses, colors and luminosities. Our catalog contains 2178 elliptical radio galaxies with flux densities greater than 2.8 mJy at 1.4 GHz from the 6dFGS survey. We find that radio AGNs with more than 200 times the median radio power have, on average, more close (r<160 kpc) companions than their radio-quiet counterparts, suggestive that mergers play a role in forming the most powerful radio galaxies. For ellipticals of fixed stellar mass, the radio power is not a function of large-scale environment nor halo mass, consistent with the radio powers of ellipticals varying by orders of magnitude over billions of years.Comment: 12 pages, 6 figure

    Heterozygous mis-sense mutations in Prkcb as a critical determinant of anti-polysaccharide antibody formation

    Get PDF
    To identify rate-limiting steps in T cell-independent type 2 (TI-2) antibody production against polysaccharide antigens, we performed a genome-wide screen by immunizing several hundred pedigrees of C57BL/6 mice segregating ENU-induced mis-sense mutations. Two independent mutations, Tilcara and Untied, were isolated that semi-dominantly diminished antibody against polysaccharide but not protein antigens. Both mutations resulted from single amino acid substitutions within the kinase domain of Protein Kinase C Beta (PKCβ). In Tilcara, a Ser552>Pro mutation occurred in helix G, in close proximity to a docking site for the inhibitory N-terminal pseudosubstrate domain of the enzyme, resulting in almost complete loss of active, autophosphorylated PKCβI whereas the amount of alternatively spliced PKCβII protein was not markedly reduced. Circulating B cell subsets were normal and acute responses to BCR-stimulation such as CD25 induction and initiation of DNA synthesis were only measurably diminished in Tilcara homozygotes, whereas the fraction of cells that had divided multiple times was decreased to an intermediate degree in heterozygotes. These results, coupled with evidence of numerous mis-sense PRKCB mutations in the human genome, identify Prkcb as a genetically sensitive step likely to contribute substantially to population variability in anti-polysaccharide antibody levels

    Osculating orbits in Schwarzschild spacetime, with an application to extreme mass-ratio inspirals

    Full text link
    We present a method to integrate the equations of motion that govern bound, accelerated orbits in Schwarzschild spacetime. At each instant the true worldline is assumed to lie tangent to a reference geodesic, called an osculating orbit, such that the worldline evolves smoothly from one such geodesic to the next. Because a geodesic is uniquely identified by a set of constant orbital elements, the transition between osculating orbits corresponds to an evolution of the elements. In this paper we derive the evolution equations for a convenient set of orbital elements, assuming that the force acts only within the orbital plane; this is the only restriction that we impose on the formalism, and we do not assume that the force must be small. As an application of our method, we analyze the relative motion of two massive bodies, assuming that one body is much smaller than the other. Using the hybrid Schwarzschild/post-Newtonian equations of motion formulated by Kidder, Will, and Wiseman, we treat the unperturbed motion as geodesic in a Schwarzschild spacetime whose mass parameter is equal to the system's total mass. The force then consists of terms that depend on the system's reduced mass. We highlight the importance of conservative terms in this force, which cause significant long-term changes in the time-dependence and phase of the relative orbit. From our results we infer some general limitations of the radiative approximation to the gravitational self-force, which uses only the dissipative terms in the force.Comment: 18 pages, 6 figures, final version to be published in Physical Review

    Identifying empirically supported treatments: What if we didn't?

    Full text link
    The conclusion of the Division 12 Task Force&apos;s report on empirically supported treatments raises 3 questions: (a) Is it desirable for the profession to specify what treatments are effective? (b) Do the criteria, either selected by the Task Force or modified by others, represent a reasonable way of identifying effective treatments? (c) Would different and less controversial conclusions have been reached if the criteria used were broadened to include naturalistic and quasi-experimental studies? It is concluded that the Task Force&apos;s selection of criteria, particularly as modified by D. L. Chambless and S. D. Hollon (1998) , was a reasonable response to these pressures. Findings from studies using less stringent and controlled research designs suggest that the proposals may have resulted in less palatable conclusions than those offered in its original report. Correspondence may be addressed to Larry E. Beutler, Counseling/Clinical/School Psychology Program

    Molecular cloning and nucleotide sequence of human glucocerebrosidase cDNA.

    Full text link

    Evaluation of HCMM data for assessing soil moisture and water table depth

    Get PDF
    Soil moisture in the 0-cm to 4-cm layer could be estimated with 1-mm soil temperatures throughout the growing season of a rainfed barley crop in eastern South Dakota. Empirical equations were developed to reduce the effect of canopy cover when radiometrically estimating the soil temperature. Corrective equations were applied to an aircraft simulation of HCMM data for a diversity of crop types and land cover conditions to estimate the soil moisture. The average difference between observed and measured soil moisture was 1.6% of field capacity. Shallow alluvial aquifers were located with HCMM predawn data. After correcting the data for vegetation differences, equations were developed for predicting water table depths within the aquifer. A finite difference code simulating soil moisture and soil temperature shows that soils with different moisture profiles differed in soil temperatures in a well defined functional manner. A significant surface thermal anomaly was found to be associated with shallow water tables

    Evaluation of HCMM data for assessing soil moisture and water table depth

    Get PDF
    Data were analyzed for variations in eastern South Dakota. Soil moisture in the 0-4 cm layer could be estimated with 1-mm soil temperatures throughout the growing season of a rainfed barley crop (% cover ranging from 30% to 90%) with an r squared = 0.81. Empirical equations were developed to reduce the effect of canopy cover when radiometrically estimating the 1-mm soil temperature, r squared = 0.88. The corrective equations were applied to an aircraft simulation of HCMM data for a diversity of crop types and land cover conditions to estimate the 0-4 cm soil moisture. The average difference between observed and measured soil moisture was 1.6% of field capacity. HCMM data were used to estimate the soil moisture for four dates with an r squared = 0.55 after correction for crop conditions. Location of shallow alluvial aquifers could be accomplished with HCMM predawn data. After correction of HCMM day data for vegetation differences, equations were developed for predicting water table depths within the aquifer (r=0.8)

    Unusual polyphosphate inclusions observed in a marine Beggiatoa strain

    Get PDF
    Sulfide-oxidizing bacteria of the genus Beggiatoa are known to accumulate phosphate intracellularly as polyphosphate but little is known about the structure and properties of these inclusions. Application of different staining techniques revealed the presence of unusually large polyphosphate inclusions in the marine Beggiatoa strain 35Flor. The inclusions showed a co-occurrence of polyphosphate, calcium and magnesium when analyzed by scanning electron microscopy and energy dispersive X-ray analysis. Similar to polyphosphate-enriched acidocalcisomes of prokaryotes and eukaryotes, the polyphosphate inclusions in Beggiatoa strain 35Flor are enclosed by a lipid layer and store cations. However, they are not notably acidic. 16S rRNA gene sequence-based phylogenetic reconstruction showed an affiliation of Beggiatoa strain 35Flor to a monophyletic branch, comprising other narrow vacuolated and non-vacuolated Beggiatoa species. The polyphosphate inclusions represent a new type of membrane surrounded storage compartment within the genus Beggiatoa, distinct from the mostly nitrate-storing vacuoles known from other marine sulfide-oxidizing bacteria of the family Beggiatoaceae
    corecore