INDUSTRY AGGLOMERATION AND INVESTMENT IN RURAL BUSINESSES

This paper examines the effects of local industry agglomeration on the investments in equipment and machinery made between 1995 and 1999 by rural Maine businesses. Empirical results indicate that industry agglomeration, measured at the county-industry and municipality-industry levels, has a positive effect on an existing establishment's probability of investment and the amount invested per worker.Community/Rural/Urban Development,

Arlenius in Basel

Betr. Manuskripte von Arnoldus Arlenius in Basel. - Mit einer Edition des Briefes von Arlenius an Oporin vom 7. Mai 1540 (Mscr Fr.-Gryn. 19/II, Nr. 282

The Effects of Amygdalar Size Normalization on Group Analysis in Late-Life Depression

Structural MRI has been utilized in numerous ways to measure morphologic characteristics of subcortical brain regions. Volumetric analysis is frequently used to quantify the size of brain structures to ultimately compare size differences between individuals. In order to make such comparisons, inter-subject variability in brain and/or head size must be taken into consideration. A heterogeneous set of methods are commonly used to normalize regional volume by brain and/or head size yielding inconsistent findings making it diffcult to interpret and compare results from published volumetric studies. This study investigated the effect that various volume normalization methodologies might have on group analysis. Specifically, the amygdalae were the regions of interest in elderly, healthy and depressed individuals. Normalization methods investigated included spatial transformations, brain and head volume, and tissue volume techniques. Group analyses were conducted with independent t-tests by dividing amygdalar volumes by various volume measures, as well as with univariate analysis of covariance (ANCOVA) analyses by using amygdalar volumes as dependent variables and various volume measures as covariates. Repeated measures ANOVA was performed to assess the effect of each normalization procedure. Results indicate that volumetric differences between groups varied based on the normalization method utilized, which may explain, in part, the discrepancy found in amygdalar volumetric studies. We believe the findings of this study are extensible to other brain regions and demographics, and thus, investigators should carefully consider the normalization methods utilized in volumetric studies to properly interpret the results and conclusions

'Trust is good, control is better': the 1974 Herstatt-Bank crisis and its implications for international regulatory reform

With its international supervisory and regulatory implications, the failure of Bankhaus Herstatt is one of the landmarks of post-war financial history. This article offers the first comprehensive historical account of the Herstatt crisis, and contributes to the wider discussions on international supervisory and regulatory reform since the mid-1970s, including regulatory capture, markets' self-regulation and resolution of failed banks. In doing so, it first argues that contrary to a widely held view, the German authorities received early and repeated warnings about Herstatt's dealings but this involved only limited and ineffective regulatory/supervisory responses, then it turns to the actual collapse of the bank in June 1974, and finally explores the wider regulatory issues raised by the Herstatt case

The use of perfluoroether lubricants in unprotected space environments

A series of ball bearing tests in simulated space environment are described which determine durability of perfluoroether lubricants. The results of the examination of the test bearings for each stage are described and experimental techniques designed to overcome lubricant degradation are outlined

Programm des Grossherzoglich hessischen Gymnasiums zu Giessen, als Einladung zu den am 17. und 18. März 1893 stattfindenden öffentlichen Prüfungen : beigegeben wird eine Abhandlung des Gymnasiallehrers Dr. Franz Schmitt: Der Unterricht in Quinta nach dem Konzentrationsprinzip. I. Sprachlich-grammatischer Teil

Da seit Ostern 1877 ein amtlicher Lehrplan für die Landesgymnasien (Revidierte Ausgabe von 1884, Darmstadt, Buchhandlung Grossherzoglichen Staatsverlags) die Aufgaben und Ziele der einzelnen Unterrichtsgegenstände für die betr. Klassen festgestellt hat, so erscheinen nur diejenigen Angaben hier, welche nicht aus dem allgemeinen Lehrplan ersichtlich oder durch die Speciallehrpläne des hiesigen Gymnasiums veranlasst sind. ..

An improved empirical bayes approach to estimating differential gene expression in microarray time-course data: BETR (Bayesian Estimation of Temporal Regulation)

<p>Abstract</p> <p>Background</p> <p>Microarray gene expression time-course experiments provide the opportunity to observe the evolution of transcriptional programs that cells use to respond to internal and external stimuli. Most commonly used methods for identifying differentially expressed genes treat each time point as independent and ignore important correlations, including those within samples and between sampling times. Therefore they do not make full use of the information intrinsic to the data, leading to a loss of power.</p> <p>Results</p> <p>We present a flexible random-effects model that takes such correlations into account, improving our ability to detect genes that have sustained differential expression over more than one time point. By modeling the joint distribution of the samples that have been profiled across all time points, we gain sensitivity compared to a marginal analysis that examines each time point in isolation. We assign each gene a probability of differential expression using an empirical Bayes approach that reduces the effective number of parameters to be estimated.</p> <p>Conclusions</p> <p>Based on results from theory, simulated data, and application to the genomic data presented here, we show that BETR has increased power to detect subtle differential expression in time-series data. The open-source R package <it>betr </it>is available through Bioconductor. BETR has also been incorporated in the freely-available, open-source MeV software tool available from <url>http://www.tm4.org/mev.html</url>.</p