Secure care pathway and standards : co-production process and implementation plans

The development of the Secure Care Pathway and Standards sets out, for the first time, national standards of what support children and young people in Scotland should expect when in, or on the edges of, secure care. Launched in October 2020, the Standards seek to ensure support is provided before, during and after a stay in secure care and that the rights of children and young people, often facing extreme vulnerabilities and risks in their lives, are respected. When implemented, the Standards will deliver a consistent, unified approach to caring for vulnerable children in all council areas, and to all children placed in secure care in Scotland. Crucially, the Standards were developed using co-production methods alongside children and young people. This article describes some of the elements of that process, as well as the impact that the new Standards will have on young people's lives in Scotland

Maine’s High- Risk Infants and Maternal Health and Wellbeing: The Maine Infant Follow-Up Project

The Maine Infant Follow-Up Project is a research-based effort to accelerate early identification of devel­opmental risk for infants whose mothers use drugs or alcohol. These infants are at high risk for neurodevel­opmental disorders, and early identification will enable early-early intervention. Targeted interven­tions will increase the chance for children to catch up developmentally during the period of most rapid brain growth in the first three years of life

A Large-Scale Evaluation of Acoustic and Subjective Music Similarity Measures

Subjective similarity between musical pieces and artists is an elusive concept, but one that music be pursued in support of applications to provide automatic organization of large music collections. In this paper, we examine both acoustic and subjective approaches for calculating similarity between artists, comapring their performance on a common database of 400 popular artists. Specifically, we evaluate acoustic techniques based on Mel-frequency cepstral coefficients and an intermediate `anchor space' of genre classification, and subjective techniques which use data from The All Music Guide, from a survey, from playlists and personal collections, and from web-text mining. We find the following: (1) Acoustic-base measures can acheive agreement with ground truth data that is at least comparable to the internal agreement between different subjective sources. However, we observe significant differences between suerficially similar distribution modeling and comparison techniques. (2) Subjective measures from diverse sources show reasonable agreement, with the measure derived from co-occurrence in personal music collections being the most reliable overall. (3) Our methodology for large-scale cross-site music similarity evaluations is practical and convenient, yielding directly comparable numbers for different approaches. In particular, we hope that for out information-retrieval-based approach to scoring similarity measures, our paradigm of sharing common feature representations, and even our particular dataset of features for 400 artists, will be useful to other researchers

A Hybrid Approach to Music Playlist Continuation Based on Playlist-Song Membership

Automated music playlist continuation is a common task of music recommender systems, that generally consists in providing a fitting extension to a given playlist. Collaborative filtering models, that extract abstract patterns from curated music playlists, tend to provide better playlist continuations than content-based approaches. However, pure collaborative filtering models have at least one of the following limitations: (1) they can only extend playlists profiled at training time; (2) they misrepresent songs that occur in very few playlists. We introduce a novel hybrid playlist continuation model based on what we name "playlist-song membership", that is, whether a given playlist and a given song fit together. The proposed model regards any playlist-song pair exclusively in terms of feature vectors. In light of this information, and after having been trained on a collection of labeled playlist-song pairs, the proposed model decides whether a playlist-song pair fits together or not. Experimental results on two datasets of curated music playlists show that the proposed playlist continuation model compares to a state-of-the-art collaborative filtering model in the ideal situation of extending playlists profiled at training time and where songs occurred frequently in training playlists. In contrast to the collaborative filtering model, and as a result of its general understanding of the playlist-song pairs in terms of feature vectors, the proposed model is additionally able to (1) extend non-profiled playlists and (2) recommend songs that occurred seldom or never in training~playlists

Birth characteristics and childhood carcinomas

BACKGROUND: Carcinomas in children are rare and have not been well studied. METHODS: We conducted a population-based case–control study and examined associations between birth characteristics and childhood carcinomas diagnosed from 28 days to 14 years during 1980–2004 using pooled data from five states (NY, WA, MN, TX, and CA) that linked their birth and cancer registries. The pooled data set contained 57 966 controls and 475 carcinoma cases, including 159 thyroid and 126 malignant melanoma cases. We used unconditional logistic regression to calculate odds ratios (ORs) and 95% confidence intervals (CIs). RESULTS: White compared with ‘other' race was positively associated with melanoma (OR=3.22, 95% CI 1.33–8.33). Older maternal age increased the risk for melanoma (OR(per 5-year age increase)=1.20, 95% CI 1.00–1.44), whereas paternal age increased the risk for any carcinoma (OR=1.10(per 5-year age increase), 95% CI 1.01–1.20) and thyroid carcinoma (OR(per 5-year age increase)=1.16, 95% CI 1.01–1.33). Gestational age <37 vs 37–42 weeks increased the risk for thyroid carcinoma (OR=1.87, 95% CI 1.07–3.27). Plurality, birth weight, and birth order were not significantly associated with childhood carcinomas. CONCLUSION: This exploratory study indicates that some birth characteristics including older parental age and low gestational age may be related to childhood carcinoma aetiology

Creating a best practice template for participant communication plans in global health clinical studies

Background Clinical trial participants have a right to be informed throughout the entire process of human subject research. As part of this pillar of research ethics, participants and other stakeholders should be made aware of research findings after a trial has been completed. Though participants have both a right, and a desire to be informed of research outcomes, studies show that they rarely receive communication about study findings. Our aim was (1) to understand what, if any, role communication plans play in current global health clinical research protocols and (2) to use our findings to develop a communication plan template tailored to clinical research carried out in low-and-middle-income countries (LMIC) while minimizing colonial assumptions. While the template was drafted in the LMIC context, the principles are universally applicable and should be considered best practices for all global health clinical trials. Methods We carried out a mixed-method study over a period of 6 months to understand the role of communication with study participants and other stakeholders in clinical trials. The semiquantitative analysis included mining publicly available clinical trial protocols for communication-related language. Qualitative interviews (n = 7) were used to gather knowledge and insight from clinical trial experts to inform the development of a communication plan template. Results None of the 48 mined clinical trial protocols included a communication plan. Of the 48, 21% (n = 21) protocols included communication-related language, and 10% (n = 5) described plans to share trial results with participants. Conclusion The use of communication plans in global health clinical trials is lacking. To our knowledge, this is the first in-depth analysis of communication plans in clinical trials to date. We recommend that researchers utilize the developed communication plan template throughout the entire research process to ensure a human-centered approach to participant communication. This communication plan should apply to all phases of a research trial, with a particular emphasis on plans to share results in an accessible and engaging manner once the trial has been completed

Understanding the utility of “Talk-to-Me” an online suicide prevention program for Australian university students

Background: Australian university students are at risk of experiencing poor mental health, being vulnerable to self-harm and suicidal ideation. Aim: “Talk-to-Me” is a suicide ideation prevention Massive open online course (MOOC) previously showing it can support Western Australian university students' knowledge of identifying and responding to suicide ideation in themselves and others. Methods: A multi-site one-group pre-test/post-test design with a 12-week follow-up explored the efficacy of “Talk-to-Me” for university students Australia-wide, evaluating the influence of COVID-19 and location. Overall, 217 students (55% female; mage = 24.93 years [18, 60]) enrolled in this study from 2020 to 2021. Participants' responses to suicidal statements, mental health literacy, generalized self-efficacy, help-seeking behavior, and overall utility of the program were collected at baseline, post-MOOC (10 weeks from baseline) and 12-week follow-up. The effect of time and location interaction was explored using a random-effects regression model. Results: Findings indicated significant improvement in participants' knowledge of positive mental health support strategies (ES = 0.42, p &lt; 0.001) and recognizing appropriate responses to suicidal statements (ES = 0.37, p &lt; 0.001) at 10-weeks, with further improvement at 12 weeks follow-up (ES = 0.47 and 0.46, p &lt; 0.001). Students reported higher generalized self-efficacy at the 12-week follow-up compared to baseline (ES = 0.19, p = 0.03) and an increased tendency to seek professional help for mental health issues (ES = 0.22, p = 0.02). Conclusion: These findings provide preliminary evidence of the efficacy of the “Talk-to-Me” program in supporting ‎university students across Australia to increase their suicide-related knowledge and skills, ‎general self-efficacy, and overall mental fitness.</p

Succinate Dehydrogenase Supports Metabolic Repurposing of Mitochondria to Drive Inflammatory Macrophages.

Activated macrophages undergo metabolic reprogramming, which drives their pro-inflammatory phenotype, but the mechanistic basis for this remains obscure. Here, we demonstrate that upon lipopolysaccharide (LPS) stimulation, macrophages shift from producing ATP by oxidative phosphorylation to glycolysis while also increasing succinate levels. We show that increased mitochondrial oxidation of succinate via succinate dehydrogenase (SDH) and an elevation of mitochondrial membrane potential combine to drive mitochondrial reactive oxygen species (ROS) production. RNA sequencing reveals that this combination induces a pro-inflammatory gene expression profile, while an inhibitor of succinate oxidation, dimethyl malonate (DMM), promotes an anti-inflammatory outcome. Blocking ROS production with rotenone by uncoupling mitochondria or by expressing the alternative oxidase (AOX) inhibits this inflammatory phenotype, with AOX protecting mice from LPS lethality. The metabolic alterations that occur upon activation of macrophages therefore repurpose mitochondria from ATP synthesis to ROS production in order to promote a pro-inflammatory state