Antidepressant Use During Pregnancy

There are no studies that have shown any antidepressant to be absolutely safe for use during any stage of pregnancy. The use of selective serotonin reuptake inhibitors (SSRIs) or tricyclic antidepressants (TCAs) during pregnancy does not increase the risk of congenital malformations or miscarriage. (Strength of Recommendation [SOR]: B, based on limited-quality, patient-oriented evidence.) The use of SSRIs or TCAs during pregnancy may increase the risk of preterm birth, low birth weight, respiratory distress, and neonatal convulsions, without obvious subsequent adverse neurodevelopmental outcomes. (SOR: B, based on limited-quality, patient-oriented evidence.

Prophylactic oxytocin: Before or after placental delivery?

Timing alone doesn't influence the drug's efficacy in preventing postpartum bleeding (strength of recommendation: B, randomized controlled trial [RCT] and prospective cohort studies)

Do antibiotics shorten symptoms in patients with purulent nasal discharge?

For most patients with purulent nasal discharge, antibiotics don't decrease symptom duration; they do increase adverse events (strength of recommendation [SOR]: A, 3 meta-analyses and 2 randomized controlled trials [RCTs]). Researchers in the field don't recommend using antibiotics as routine treatment for purulent rhinorrhea associated with symptoms of upper respiratory infection ([SOR]: C, expert opinion)