Repertory of Reading at the Bogolsovsk Factories at the Middle of the XIXth Century

На основе архивных источников анализируется состав и источники комплектования библиотеки Богословских заводов, что позволяет поставить ее в ряд старейших и богатейших библиотек заводского Урала. Реконструируется репертуар чтения на Богословских заводах в середине XIX в.The inventories and sources of acquisition of books for the library of the Bogoslovsk factories are analyzed on the basis of archival data. This library can be considered as one of the oldest and richest libraries of the Ural. The article gives a reconstruction of the repertory of reading at the Bogoslovsk factories in the middle of the XIXth century

Specializing and profiling of journalistic practice in the terms of multimedia reality

In this article specializing and profiling of journalistic practice are examined as effective media management instruments. The author draws attention to the process of transformation of these elements to multimedia level.Специализация и профилизация журналиста рассматриваются в статье в качестве эффективных инструментов медиаменеджмента. Особое внимание обращается на процесс трансформации этих элементов в условиях мультимедийности

Chemical potential of quasi-equilibrium magnon gas driven by pure spin current

We show experimentally that the spin current generated by the spin Hall effect drives the magnon gas in a ferromagnet into a quasi-equilibrium state that can be described by the Bose-Einstein statistics. The magnon population function is characterized either by an increased effective chemical potential or by a reduced effective temperature, depending on the spin current polarization. In the former case, the chemical potential can closely approach, at large driving currents, the lowest-energy magnon state, indicating the possibility of spin current-driven Bose-Einstein condensation

Possibilities of mitigation measures utilization at brownfield regeneration

Реконструкция заброшенных и пришедших в ветхость городских территорий ресурсоемка и может требовать длительного времени. Не всегда территории находятся на окраине города. Альтернативой реконструкции могут являться меры по смягчению последствий деградации территорий и сооружений. В статье исследуются возможности применения мер по смягчению последствий деградаций на примере Чехии, Словакии, Германи

The 35S U5 snRNP is generated from the activated spliceosome during In vitro splicing

Primary gene transcripts of eukaryotes contain introns, which are removed during processing by splicing machinery. Biochemical studies In vitro have identified a specific pathway in which introns are recognised and spliced out. This occurs by progressive formation of spliceosomal complexes designated as E, A, B, and C. The composition and structure of these spliceosomal conformations have been characterised in many detail. In contrast, transitions between the complexes and the intermediates of these reactions are currently less clear. We have previously isolated a novel 35S U5 snRNP from HeLa nuclear extracts. The protein composition of this particle differed from the canonical 20S U5 snRNPs but was remarkably similar to the activated B* spliceosomes. Based on this observation we have proposed a hypothesis that 35S U5 snRNPs represent a dissociation product of the spliceosome after both transesterification reactions are completed. Here we provide experimental evidence that 35S U5 snRNPs are generated from the activated B* spliceosomes during In vitro splicing

Verification of overall effectivity of brownfield regeneration based on mathematical model

Восстановление заброшенных городских и промышленных территорий (объектов) является актуальным в современных условиях. Практически везде существуют объекты, которые осложняют дальнейшее развитие населенного пункта. Математическое моделирование позволяет спрогнозировать эффективность восстановления таких территорий. В статье показана методология прогнозирования и комплексность получаемого результата, имеющего значительную экономическую ценность на примере заброшенной шахт

Values and preferences for hepatitis C self-testing among people who inject drugs in Kyrgyzstan

Background: The prevalence of hepatitis C virus (HCV) among people who inject drugs (PWID) continues to be a major public-health burden in this highly stigmatised population. To halt transmission of HCV, rapid HCV self-testing kits represent an innovative approach that could enable PWID to know their HCV status and seek treatment. As no HCV test has yet been licenced for self-administration, it is crucial to obtain knowledge around the factors that may deter or foster delivery of HCV self-testing among PWID in resource-constrained countries. Methods: A qualitative study to assess values and preferences relating to HCV self-testing was conducted in mid-2020 among PWID in the Bishkek and Chui regions of Kyrgyzstan. Forty-seven PWID participated in 15 individual interviews, two group interviews (n = 12) and one participatory action-research session (n = 20). Responses were analysed using a thematic analysis approach with 4 predefined themes: awareness of HCV and current HCV testing experiences, and acceptability and service delivery preferences for HCV self-testing. Informants’ insights were analysed using a thematic analysis approach. This research received local ethics approval. Results: Awareness of HCV is low and currently PWID prefer community-based HCV testing due to stigma encountered in other healthcare settings. HCV self-testing would be accepted and appreciated by PWID. Acceptability may increase if HCV self-testing: was delivered in pharmacies or by harm reduction associations; was free of charge; was oral rather than blood-based; included instructions with images and clear information on the test’s accuracy; and was distributed alongside pre- and post-testing counselling with linkage to confirmatory testing support. Conclusions: HCV self-testing could increase awareness of and more frequent testing for HCV infection among PWID in Kyrgyzstan. It is recommended that peer-driven associations are involved in the delivery of any HCV self-testing. Furthermore, efforts should be maximised to end discrimination against PWID at the healthcare institutions responsible for confirmatory HCV testing and treatment provision. © 2021, The Author(s)

Continuous Modeling of Arterial Platelet Thrombus Formation Using a Spatial Adsorption Equation

In this study, we considered a continuous model of platelet thrombus growth in an arteriole. A special model describing the adhesion of platelets in terms of their concentration was derived. The applications of the derived model are not restricted to only describing arterial platelet thrombus formation; the model can also be applied to other similar adhesion processes. The model reproduces an auto-wave solution in the one-dimensional case; in the two-dimensional case, in which the surrounding flow is taken into account, the typical torch- like thrombus is reproduced. The thrombus shape and the growth velocity are determined by the model parameters. We demonstrate that the model captures the main properties of the thrombus growth behavior and provides us a better understanding of which mechanisms are important in the mechanical nature of the arterial thrombus growth