Invariance quantum groups of the deformed oscillator algebra

A differential calculus is set up on a deformation of the oscillator algebra. It is uniquely determined by the requirement of invariance under a seven-dimensional quantum group. The quantum space and its associated differential calculus are also shown to be invariant under a nine generator quantum group containing the previous one.Comment: 13 pages, Late

Follicular lymphoma-like B cells in healthy individuals: a novel intermediate step in early lymphomagenesis

Follicular lymphoma is one of the most common adult lymphoma, and remains virtually incurable despite its relatively indolent nature. t(14;18)(q32;q21) translocation, the genetic hallmark and early initiating event of follicular lymphoma (FL) pathogenesis, is also present at low frequency in the peripheral blood of healthy individuals. It has long been assumed that in healthy individuals t(14;18) is carried by circulating quiescent naive B cells, where its oncogenic potential would be restrained. Here, we question this current view and demonstrate that in healthy individuals, t(14;18) is actually carried by an expanding population of atypical B cells issued from germinal centers, displaying genotypic and phenotypic features of FL, and prone to constitute potent premalignant FL niches. These findings strongly impact both on the current understanding of disease progression and on the proper handling of t(14;18) frequency in blood as a potential early biomarker for lymphoma

Corallistin A, a second example of a free porphyrin from a living organism : isolation from the demosponge Corallistes sp. of the coral see and inhibition of abnormal cells

It is shown that the demosponge #Corallistes sp. (#Tetractinomorpha, #Lithistida, #Corallistidae) collected in the Coral Sea, contains corallistin A, the second example, of a free porphyrin from a living organism. The compound proved to be active against the Kb cell line. In contrast with the geoporphyrins which do not bear any O-atom corallistin A carries two carboxylic groups. (Résumé d'auteur

Cell-to-cell heterogeneity in Sox2 and Bra expression guides progenitor motility and destiny.

Although cell-to-cell heterogeneity in gene and protein expression within cell populations has been widely documented, we know little about its biological functions. By studying progenitors of the posterior region of bird embryos, we found that expression levels of transcription factors Sox2 and Bra, respectively involved in neural tube (NT) and mesoderm specification, display a high degree of cell-to-cell heterogeneity. By combining forced expression and downregulation approaches with time-lapse imaging, we demonstrate that Sox2-to-Bra ratio guides progenitor's motility and their ability to stay in or exit the progenitor zone to integrate neural or mesodermal tissues. Indeed, high Bra levels confer high motility that pushes cells to join the paraxial mesoderm, while high levels of Sox2 tend to inhibit cell movement forcing cells to integrate the NT. Mathematical modeling captures the importance of cell motility regulation in this process and further suggests that randomness in Sox2/Bra cell-to-cell distribution favors cell rearrangements and tissue shape conservation

Different immune responses to three different vaccines following H6N1 low pathogenic avian influenza virus challenge in Taiwanese local chicken breeds.

BACKGROUND: H6N1 low pathogenic avian influenza virus (LPAIV) are frequently isolated in Taiwan and lead to significant economic losses, either directly or indirectly through association with other infectious diseases. This study investigates immune responses to three different vaccines following a H6N1 challenge in different local breeds. METHODS: Experimental animals were sampled from six local chicken breeds maintained at the National Chung-Hsing University, namely Hsin-Yi, Ju-Chi, Hua-Tung (Taiwan), Quemoy (Quemoy Island), Shek-Ki (China), Nagoya (Japan) and a specific pathogen free (SPF) White Leghorn line. A total number of 338 chickens have been distributed between a control and a challenge group, H6N1 challenge was performed at 7 weeks of age; vaccination against Newcastle Disease (ND), Infectious Bursal Disease (IBD) and Infectious Bronchitis (IB) was performed at 11 weeks. The anti-H6N1 LPAIV antibody titers were measured by ELISA at days 0, 7, 14 and 21 after challenge, and the anti-ND, anti-IBD and anti-IB antibody titers were measured by inhibition of hemagglutination test and ELISA at days 0, 14, 28 after vaccination. RESULTS: There was no effect of the H6N1 LPAIV challenge at 7 weeks of age on the subsequent responses to ND and IBD vaccine at 11 weeks of age, but, surprisingly, the H6N1 LPAIV challenge significantly affected antibody levels to IB vaccine in some breeds, since IB0 and IB14 antibody titers were lower in the challenge groups. However, there was no significant difference in IB28 antibody titers among the experimental groups. CONCLUSIONS: Local breeds have different immune response to H6N1 LPAIV challenge and subsequent vaccines. Differences dealt mainly with kinetics of response and with peak values. Quemoy exhibited higher antibody levels to H6N1, ND and IBD. The negative effect of the H6N1 LPAIV challenge on IB vaccine response may be related to the fact that both viruses target the lung tissues, and the type of local immune response induced by LPAIV challenge may not be favourable for birds to make optimum IB-specific antibody response.RIGHTS : This article is licensed under the BioMed Central licence at http://www.biomedcentral.com/about/license which is similar to the 'Creative Commons Attribution Licence'. In brief you may : copy, distribute, and display the work; make derivative works; or make commercial use of the work - under the following conditions: the original author must be given credit; for any reuse or distribution, it must be made clear to others what the license terms of this work are

Rushes summarization by IRIM consortium: redundancy removal and multi-feature fusion

International audienceIn this paper, we present the first participation of a consortium of French laboratories, IRIM, to the TRECVID 2008 BBC Rushes Summarization task. Our approach resorts to video skimming. We propose two methods to reduce redundancy, as rushes include several takes of scenes. We also take into account low and midlevel semantic features in an ad-hoc fusion method in order to retain only significant content

Un ensemble funéraire du Haut-Empire le long de la voie de l’Océan (Lyon 9e)

L’aire funéraire découverte au 30-32 rue de Bourgogne, dans la plaine de Vaise à Lyon, a été implantée le long de la voie de l’Océan, dont un tronçon a été mis au jour. La durée de l’occupation funéraire s’étend sur une période relativement courte : du début du Ier siècle ap. J.-C. jusqu’au début du IIe siècle. Cent quarante-cinq structures liées aux rituels funéraires ont été fouillées : dix-neuf bûchers en fosse avec ou sans vestiges osseux humains, soixante-dix-neuf dépôts de crémation mixte ou non, vingt-trois dépôts de résidus, vingt et une inhumations, une aire de crémation, un dépôt de céramique et un four.L’étude de la gestion des tombes dans l’espace démontre un désir de rapprocher certains défunts et exclut un phénomène d’éventuel empiétement induit par l’étroitesse de l’occupation par rapport à la voie. Au cours de son utilisation, l’accès à cet espace funéraire s’est restreint aux adultes et certains gestes se sont modifiés. Le prélèvement des restes osseux crémés sur le bûcher est de plus en plus faible au fil des années. Ce changement dans la collecte des restes du défunt est contemporain du développement du bûcher en fosse. La gestion de l’espace, les structures, les gestes et les rituels auxquels ils sont liés sont conformes à ceux observés sur les sites lyonnais contemporains. L’implantation de l’aire funéraire dans un contexte environnemental plutôt défavorable, probablement responsable de son abandon, est peut-être l’indice que l’installation des tombes dans ce secteur de Lyon était liée à une contrainte financière.The cemetery discovered at 30-32 rue de Bourgogne in the Vaise plain at Lyon was in fact located along the “Ocean” Roman Road, part of which has also been discovered. The funerary activity of the site lasted a relatively short period from the beginning of the 1st to the beginning of the 2nd century AD. 145 funerary structures were unearthed, including nineteen pyres in pits with or without human remains, seventy-nine cremation deposits (mixed or not), twenty-three deposits of cremation residues, twenty-one inhumations, a cremation area, a pottery deposit and an oven.This study reveals how the site was managed by the grouping of tombs, whilst avoiding any encroachment inferred by the narrowness of the site in relation to the road. During the site’s use, its access was restricted to adults and certain practices were progressively modified. The taking of bone remains from the funerary pyres becomes less prominent with time and this change coincides with the development of pit pyres. The site’s management, its structures, funerary practices and rituals are typical of what has been already observed on other sites in the Lyon area. The cemetery’s location in a somewhat unfavourable context is probably why it was abandoned and could also indicate that funerary sites in Lyon were subjected to some kind of tax.Das 30-32, rue de Bourgogne in der Ebene von Vaise in Lyon entdeckte Grabareal zog sich entlang der auf einem Teilstück freigelegten Ozean-Straße. Die Belegung des Grabareals erstreckt sich über eine relativ kurze Zeitspanne, d.h. vom Beginn des 1. bis zum Beginn des 2. Jh. n. Chr. 140 Strukturen, die einen Zusammenhang mit den Grabriten aufweisen, wurden ergraben: 19 Grubenscheiterhaufen mit oder ohne Leichenbrand, 79 gemischte oder ungemischte Aschedepots, 23 Depots von Verbrennungsresten, 21 Körpergräber, ein Verbrennungsareal, ein Keramikdepot und ein Ofen.Die Untersuchung der räumlichen Verteilung der Gräber zeugt von dem Wunsch, einige Verstorbene unweit voneinander zu begraben, sie schließt jedoch aus, dass eine mögliche Überschneidung auf die Eingeengtheit der Nekropole im Vergleich zur Straße zurückzuführen ist. Im Laufe seiner Benutzung beschränkt sich die Belegung des Grabbereichs auf Erwachsene, einige Riten unterliegen einer Wandlung. Mit der Zeit verliert der Brauch, den Leichenbrand auf dem Scheiterhaufen auszulesen, an Bedeutung. Diese Wandlung bezüglich des Auslesens der Überreste des Verstorbenen vollzieht sich gleichzeitig mit der Herausbildung des Grubenscheiterhaufens. Die räumliche Organisation, die Strukturen, die mit diesen verknüpften Gesten und Rituale entsprechen denen der zeitgenössischen Fundstätten Lyons. Die Lage des Grabareals in einer eher ungünstigen Umgebung, die wahrscheinlich zu seiner Aufgabe geführt hat, mag ein Hinweis dafür sein, dass die Anlegung der Gräber in diesem Sektor Lyons finanziell bedingt war