Lithiasis-induced acute kidney injury: Is ultrasonography enough?

Obstructive acute kidney injury(AKI) is relatively common, reported in 8% to 17% of cases presenting with community-acquired AKI. It is more frequent in males of advanced age, usually from bladder outlet obstruction. Guidelines recommend imaging, namely a renal tract ultrasound (US), within 24 hours from admission to rule-out obstruction and guarantee recovery of renal function. Lithiasis is not a common cause of AKI (1\u20132% of obstructive cases) and it is reported that only 0.72% of patients with urinary calculi develop AKI from stones. It is known that US may have difficulties in demonstrating stones-related obstructionand that unenhanced CT ismost sensitive and specific for this purpose. We report therefore the imaging findings in a series of patients with lithiasis-induced AKI to understand the respective roles of these techniques

Etude de la reactivite du dioxyde d'uranium monocristallin vis-a-vis des processus de dissolution en milieu acide cinetique et reactivite aux interfaces.

International audienc

Environmental impact caused by wild ungulates in protected areas

Protected areas play a crucial role for conservation of natural habilats and ecosystems. Protecting biodiversity means maintaining in good condition ecological processes in order to ensure a good state of harmony between natural resources and environmental conservation. It is known that one of the major threats of the Conservation is the presence of alien or invasive species, especial/y if they are introduced in protected areas. The International Union for Conservation of Nature (IUCN) writes in the list of the 100 invasive species the wild boar (Sus scrofa L.) and the goat (Capra hircus L.). These ungulates represent a serious threat for natural ecosystems because they are able to alter natural habilats reducing biodiversity. The primary aim of this study is to evaluate some aspects connected with environmental relationships mainly between flora and fauna in protected areas, focusing on wild boars and feral goats. Secondly, it is analysed "Human dimension" aspect caused by presence and damage of wild animals finked to damage to crops and to dry stone wall supporting the typical cultivated terraces. To reach our goal we use as a case study the Portofino Natural Park in North-West Italy, because it houses one of the largest biodiversity concentration in the Mediterranean area. In this protected area the wild boar is the most invasive between the two studied animai species, because of soil damages that influence hydro-geological balance of territory. Finally, this species can quickly increase its population for the high prolificacy and low biological and predator mortality

The added value of simultaneous palpation during scrotal ultrasound

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The role of models in science: an experience with Drosophila

Model organisms play an important role in conveying biological concepts. They are more amenable to asking certain questions due to their simplicity of structure and features. The fruit fly Drosophila melanogaster has been the most popular eukaryotic organism used in classrooms, with a short life cycle of two weeks, making it possible to study numerous generations in a short period. The use of Drosophila is a powerful tool also in teaching Life Sciences. In fact, it allows the observation of sexual dimorphism, of mutants and of the life cycle

Myostatin mediates abdominal aortic atherosclerosis progression by inducing vascular smooth muscle cell dysfunction and monocyte recruitment

Myostatin (Mstn) is a skeletal muscle growth inhibitor involved in metabolic disorders and heart fibrosis. In this study we sought to verify whether Mstn is also operative in atherosclerosis of abdominal aorta. In human specimens, Mstn expression was almost absent in normal vessels, became detectable in the media of non-progressive lesions and increased with the severity of the damage. In progressive atherosclerotic lesions, Mstn was present in the media, neointima, plaque shoulder and in infiltrating macrophages. Mstn co-localized with \uce\ub1-smooth muscle actin (\uce\ub1-SMA) staining and with some CD45+ cells, indicating Mstn expression in VSMCs and bloodstream-derived leukocytes. In vitro, Mstn was tested in VSMCs and monocytes. In A7r5 VSMCs, Mstn downregulated proliferation and Smoothelin mRNA, induced cytoskeletal rearrangement, increased migratory rate and MCP-1/CCR2 expression. In monocytes (THP-1 cells and human monocytes), Mstn acted as a chemoattractant and increased the MCP-1-dependent chemotaxis, F-actin, \uce\ub1-SMA, MCP-1 and CCR2 expression; in turn, MCP-1 increased Mstn mRNA. Mstn induced JNK phosphorylation both in VSMCs and monocytes. Our results indicate that Mstn is overexpressed in abdominal aortic wall deterioration, affects VSMCs and monocyte biology and sustains a chronic inflammatory milieu. These findings propose to consider Mstn as a new playmaker in atherosclerosis progression