Energy functional for the three-level Lipkin model

We compute the energy functional of a three-level Lipkin model via a Legrendre transform and compare exact numerical results with analytical solutions obtained from the random phase approximation (RPA). Except for the region of the phase transition, the RPA solutions perform very well. We also study the case of three non-degenerate levels and again find that the RPA solution agrees well with the exact numerical result. For this case, the analytical results give us insight into the form of the energy functional in the presence of symmetry-breaking one-body potentials.Comment: 6 pages, 5 figure

Advanced burning stages and fate of 8-10 Mo stars

The stellar mass range 8<M/Mo<12 corresponds to the most massive AGB stars and the most numerous massive stars. It is host to a variety of supernova progenitors and is therefore very important for galactic chemical evolution and stellar population studies. In this paper, we study the transition from super-AGB star to massive star and find that a propagating neon-oxygen burning shell is common to both the most massive electron capture supernova (EC-SN) progenitors and the lowest mass iron-core collapse supernova (FeCCSN) progenitors. Of the models that ignite neon burning off-center, the 9.5Mo model would evolve to an FeCCSN after the neon-burning shell propagates to the center, as in previous studies. The neon-burning shell in the 8.8Mo model, however, fails to reach the center as the URCA process and an extended (0.6 Mo) region of low Ye (0.48) in the outer part of the core begin to dominate the late evolution; the model evolves to an EC-SN. This is the first study to follow the most massive EC-SN progenitors to collapse, representing an evolutionary path to EC-SN in addition to that from SAGB stars undergoing thermal pulses. We also present models of an 8.75Mo super-AGB star through its entire thermal pulse phase until electron captures on 20Ne begin at its center and of a 12Mo star up to the iron core collapse. We discuss key uncertainties and how the different pathways to collapse affect the pre-supernova structure. Finally, we compare our results to the observed neutron star mass distribution.Comment: 20 pages, 14 figures, 1 table. Submitted to ApJ 2013 February 19; accepted 2013 June

Multistate Assessment of Public Health Surveillance Relevant to American Indians and Alaska Natives, 2007

Improving the health of American Indian and Alaska Native (AI/AN) populations involves multiple agencies, levels of government, and jurisdictions. We assessed collaboration between state health departments and AI/AN Tribes and agencies through an online survey of State Epidemiologists. Frequencies and percentages of responses were examined by univariate and bivariate analyses. Among 39 states with federally recognized or state-recognized Tribes or federally funded urban Indian health centers, 25 (64%) participated. Nineteen had discussed public health surveillance with an AI/ AN government or nongovernment entity in the past 2 years (10 (53%) of these had ongoing, regular discussions about public health surveillance; nine (47%) had these discussions as needed). Nine (36%) responding states have a point person for working with AI/AN communities and/or agencies on public health surveillance. Four (16%) states have an active memorandum of understanding or other formal agreement with an AI/AN government or nongovernment entity regarding surveillance. To prepare for public health emergencies, six (24%) states involve the Indian Health Service, and eight (47%) involve another AI/AN entity. Functional relationships between state health departments and AI/AN agencies have not been consistently established. Strengthening these relationships will facilitate surveillance and response capacity to address continuing and emerging public health problems

The i-process and CEMP-r/s stars

© Copyright owned by the author(s) under the terms of the Creative Commons Attribution-NonCommercial-ShareAlike Licence. We investigate whether the anomalous elemental abundance patterns in some of the C-enhanced metal-poor-r/s (CEMP-r/s) stars are consistent with predictions of nucleosynthesis yields from the i-process, a neutron-capture regime at neutron densities intermediate between those typical for the slow (s) and rapid (r) processes. Conditions necessary for the i-process are expected to be met at multiple stellar sites, such as the He-core and He-shell flashes in low-metallicity low-mass stars, super-AGB and post-AGB stars, as well as low-metallicity massive stars. We have found that single-exposure one-zone simulations of the i-process reproduce the abundance patterns in some of the CEMP-r/s stars much better than the model that assumes a superposition of yields from s and r-process sources. Our previous study of nuclear data uncertainties relevant to the i-process revealed that they could have a significant impact on the i-process yields obtained in our idealized one-zone calculations, leading, for example, to ∼ 0:7dex uncertainty in our predicted [Ba/La] ratio. Recent 3D hydrodynamic simulations of convection driven by a He-shell flash in post-AGB Sakurai's object have discovered a new mode of non-radial instabilities: the Global Oscillation of Shell H-ingestion. This has demonstrated that spherically symmetric stellar evolution simulations cannot be used to accurately model physical conditions for the i-process

Surveillance of Infectious Diseases Among American Indians and Alaska Natives

We assessed participation in public health surveillance networks among Indian Health Service, tribal, and urban (I/T/U) Indian health facilities for a group of infectious diseases, and barriers to participation. We conducted surveys of I/T/U facilities and key informant interviews with representatives of tribal, urban, and national American Indian/Alaska Native (AI/AN) agencies. For the surveys, frequencies and percentages of responses in each response category were calculated. Qualitative methods were used to analyze interview content. The proportion of facilities participating in case reporting is suboptimal across facility types and diseases. Even when reporting is occurring, there is little feedback to tribal agencies. Lack of trust between tribal authorities and state/local governments, lack of feedback on surveillance efforts, and gaps in coordination of activities were identified as barriers to participation in surveillance. Our findings indicate weaknesses in surveillance systems for monitoring infectious diseases among AI/AN people, and have implications for addressing health disparities

The i-process and CEMP-r/s stars

© Copyright owned by the author(s) under the terms of the Creative Commons Attribution-NonCommercial-ShareAlike Licence. We investigate whether the anomalous elemental abundance patterns in some of the C-enhanced metal-poor-r/s (CEMP-r/s) stars are consistent with predictions of nucleosynthesis yields from the i-process, a neutron-capture regime at neutron densities intermediate between those typical for the slow (s) and rapid (r) processes. Conditions necessary for the i-process are expected to be met at multiple stellar sites, such as the He-core and He-shell flashes in low-metallicity low-mass stars, super-AGB and post-AGB stars, as well as low-metallicity massive stars. We have found that single-exposure one-zone simulations of the i-process reproduce the abundance patterns in some of the CEMP-r/s stars much better than the model that assumes a superposition of yields from s and r-process sources. Our previous study of nuclear data uncertainties relevant to the i-process revealed that they could have a significant impact on the i-process yields obtained in our idealized one-zone calculations, leading, for example, to ∼ 0:7dex uncertainty in our predicted [Ba/La] ratio. Recent 3D hydrodynamic simulations of convection driven by a He-shell flash in post-AGB Sakurai's object have discovered a new mode of non-radial instabilities: the Global Oscillation of Shell H-ingestion. This has demonstrated that spherically symmetric stellar evolution simulations cannot be used to accurately model physical conditions for the i-process

Structural analysis of pathogenic mutations in the DYRK1A gene in patients with developmental disorders.

Haploinsufficiency in DYRK1A is associated with a recognizable developmental syndrome, though the mechanism of action of pathogenic missense mutations is currently unclear. Here we present 19 de novo mutations in this gene, including five missense mutations, identified by the Deciphering Developmental Disorder study. Protein structural analysis reveals that the missense mutations are either close to the ATP or peptide binding-sites within the kinase domain, or are important for protein stability, suggesting they lead to a loss of the protein's function mechanism. Furthermore, there is some correlation between the magnitude of the change and the severity of the resultant phenotype. A comparison of the distribution of the pathogenic mutations along the length of DYRK1A with that of natural variants, as found in the ExAC database, confirms that mutations in the N-terminal end of the kinase domain are more disruptive of protein function. In particular, pathogenic mutations occur in significantly closer proximity to the ATP and the substrate peptide than the natural variants. Overall, we suggest that de novo dominant mutations in DYRK1A account for nearly 0.5% of severe developmental disorders due to substantially reduced kinase function