Kako smo poboljšanim mjerama praćenja izloženosti i zaštite na radu snizili razine formaldehida u zraku u sveučilišnoj bolnici u Italiji: sažetak 20 godina iskustava

The last two decades have been crucial for the assessment of airborne formaldehyde (FA) exposure in healthcare environments due to changes in limits and reference values, definition of carcinogenicity, and new monitoring methods. The aim of this study was to analyse twenty years (1999–2019) of experience in automatic, continuous airborne FA monitoring in the Pathology Laboratory and operating rooms at the Careggi University Hospital, Florence, Italy. These 20 years saw gradual improvements in FA monitoring of exposed employees considered at maximum risk, including improvements in analytical methods of detection and sampling strategies, which came with changes in procedures and workflow operations. In 2019, after the adoption of safe practices, including a closed-circuit system using pre-loaded containers and a vacuum sealing, 94 % of the total measurements (FA concentrations) were lower than 16 μg/m3, and only 6 % ranged from 21 to 75 μg/m3. In the studied work units, the ratio between area and personal readings ranged from 0.9 to 1.0, both for long and short-term sampling. Personal sampling was simplified with a new workstation, which integrated different monitoring systems into an innovative ergonomic armchair equipped with personal sampling devices. Area monitoring was also improved with a real-time, continuous photoacoustic instrument. Over these 20 years, FA exposure significantly dropped, which coincided with optimised histology workflow and implementation of safety practices. For high-throughput screening and cost savings we propose an innovative ergonomic armchair station which allows remote continuous monitoring.Posljednja dva desetljeća bila su iznimno važna za procjenu izloženosti formaldehidu (FA) u zraku u zdravstvenim ustanovama zahvaljujući promjenama u preporučenim maksimalnim i referentnim vrijednostima, definiciji njegove kancerogenosti i novim metodama mjerenja/praćenja. Cilj je ovog istraživanja bio analizirati dvadeset godina (1999. – 2000.) iskustva u automatskom, kontinuiranom mjerenju razina FA-a u laboratoriju za patologiju i operacijskim dvoranama talijanske sveučilišne bolnice Careggi u Firenzi. Tijekom tih dvadeset godina bolnica je postupno poboljšavala metode praćenja razina FA-a i osoblja izloženoga najvećem riziku, analitičke metode detekcije i strategije uzorkovanja koje su bile popraćene promjenama u odgovarajućim postupcima i organizaciji rada. Nakon usvajanja novih postupaka zaštite na radu 2019., uključujući i zatvoreni sustav rukovanja spremnicima i sustav vakuumskoga zatvaranja, razine FA-a u 94 % izmjera bile su niže od 16 μg/m3, a samo 6 % izmjera kretalo se u rasponu od 21 do 75 μg/m3. Omjer izmjerenih razina prostornih i osobnih skupljača uzoraka u ispitanim scenarijima kretao se od 0,9 do 1,0, bez obzira na to je li posrijedi kratkoročno ili dugoročno mjerenje. Mjerenje osobnim mjeračima dodatno je pojednostavljeno novom radnom stanicom u obliku ergonomskoga radnog stolca, koji u sebi objedinjuje različite sustave praćenja i osobne mjerače. Nisu zaostala ni poboljšanja u prostornom mjerenju, budući da je uveden novi fotoakustični uređaj za kontinuirano mjerenje u stvarnom vremenu. U tih 20 godina izloženost FA-u drastično se smanjila, što je popraćeno poboljšanom organizacijom obrade histoloških uzoraka i zaštite na radu. Radnu stanicu u obliku ergonomskoga stolca svakako preporučujemo zbog velikog kapaciteta protoka za probirno mjerenje, značajnih ušteda i mogućnosti daljinskog upravljanja

Coding of Far and Near Space in Neglect Patients

Far (extrapersonal) and near (peripersonal) spaces are behaviorally defined as the space outside armreaching distance and the space within arm-reaching distance. Animal and human studies have shown that this behavioral distinction corresponds in the brain to a composite neural architecture for space representation. In this paper we discuss how the activation of the neural correlates of far and near space can be modulated by the use of tools that change the effective spatial relationship between the agent’s body and the target object. When subjects reach for a far object with a tool, it is possible to show that far space is remapped as near. We shall also argue that space remapping may not occur when far space is reached by walking instead of using a tool

Constraining the fraction of binary black holes formed in isolation and young star clusters with gravitational-wave data

Ten binary black-hole mergers have already been detected during the first two observing runs of advanced LIGO and Virgo, and many more are expected to be observed in the near future. This opens the possibility for gravitational-wave astronomy to better constrain the properties of black hole binaries, not only as single sources, but as a whole astrophysical population. In this paper, we address the problem of using gravitational-wave measurements to estimate the proportion of merging black holes produced either via isolated binaries or binaries evolving in young star clusters. To this end, we use a Bayesian hierarchical modeling approach applied to catalogs of merging binary black holes generated using state-of-the-art population synthesis and N-body codes. In particular, we show that, although current advanced LIGO/Virgo observations only mildly constrain the mixing fraction $f \in [0,1]$ between the two formation channels, we expect to narrow down the fractional errors on $f$ to $10-20\%$ after a few hundreds of detections.Comment: 17 pages, 4 figure

Constraining modifications of black hole perturbation potentials near the light ring with quasinormal modes

In modified theories of gravity, the potentials appearing in the Schr\"odinger-like equations that describe perturbations of non-rotating black holes are also modified. In this paper we ask: can these modifications be constrained with high-precision gravitational-wave measurements of the black hole's quasinormal mode frequencies? We expand the modifications in a small perturbative parameter regulating the deviation from the general-relativistic potential, and in powers of $M/r$. We compute the quasinormal modes of the modified potential up to quadratic order in the perturbative parameter. Then we use Markov-chain-Monte-Carlo (MCMC) methods to recover the coefficients in the $M/r$ expansion in an ``optimistic'' scenario where we vary them one at a time, and in a ``pessimistic'' scenario where we vary them all simultaneously. In both cases, we find that the bounds on the individual parameters are not robust. Because quasinormal mode frequencies are related to the behavior of the perturbation potential near the light ring, we propose a different strategy. Inspired by Wentzel-Kramers-Brillouin (WKB) theory, we demonstrate that the value of the potential and of its second derivative at the light ring can be robustly constrained. These constraints allow for a more direct comparison between tests based on black hole spectroscopy and observations of black hole `shadows'' by the Event Horizon Telescope and future instruments.Comment: 12 pages, 7 figure

Stakeholder perspectives to prevent soil organic matter decline in Northeastern Italy

A transition from conventional to more sustainable soil management measures (SMMs) is required to reverse the current soil organic matter (SOM) losses in the agroecosystems. Despite the innovations and technologies that are available to prevent SOM decline, top–down knowledge transfer schemes that incentivize a certain measure are often ineffective. Here, we discuss relevant outcomes from a participatory approach where researchers, farmers, practitioners and government officials have discussed opportunities and barriers around SMM application to prevent SOM decline. Within a series of workshops, stakeholders identified, scored, and selected SMMs to fieldtests and evaluated the benefits and drawbacks from their application. Results showed that the stakeholders recognized the need for innovations, although they valued the most promising SMM as already available continuous soil cover and conservation agriculture. In contrast, more innovative SMMs, such as biochar use and the variable rate application of organic amendments through precision farming, were the least valued, suggesting that people’s resistance to new technologies is often governed by the socio-cultural perception of them that goes beyond the economic and technological aspects. The valuation of benefits and drawbacks by stakeholders on trialed measures emphasized that stakeholders’ perspective about soil management is a combination of economic, environmental, and socio-cultural aspects, thus corroborating the need for transdisciplinary bottom–up approaches to prevent SOM depletion and increase soil rehabilitation and SOM content

Gravitational-wave detection rates for compact binaries formed in isolation: LIGO/Virgo O3 and beyond

Using simulations performed with the population synthesis code MOBSE, we compute the merger rate densities and detection rates of compact binary mergers formed in isolation for second- and third-generation gravitational-wave detectors. We estimate how rates are affected by uncertainties on key stellar-physics parameters, namely common envelope evolution and natal kicks. We estimate how future upgrades will increase the size of the available catalog of merger events, and we discuss features of the merger rate density that will become accessible with third-generation detectors.Comment: 9 pages, 4 figures, 2 tables Matches the published versio

Potential Impact of Microplastics and Additives on the Health Status of Loggerhead Turtles (Caretta caretta) Stranded Along the Central Adriatic Coast

AbstractLoggerhead sea turtle (C. caretta) is the official European bioindicator of marine litter in the Mediterranean Sea. In 2019, 8 sea turtles, out of 28 specimens loggerhead on the Adriatic coast of Molise, were subjected to necropsy. The intestinal contents were collected and the microplastics until 0.45 μm were extracted. Qualitative and quantitative assessments were performed by stereomicroscope observation and spectroscopic analyses (attenuated total reflection-Fourier transform infrared spectroscopy, ATR-FTIR and Raman microspectroscopy, RMS). Moreover, the analytical quantification of polyethylene terephthalate (PET), polycarbonate (PC), para phthalic acid (PTA) and bisphenol A (BPA) in fat and liver tissues was performed by LC-MS/MS. Microparticles ranging from 0.45 μm to 1 mm were found in all turtles, for a total of 623, while plastic litter greater than 1 mm were found only in 4 specimens (ranging from 0.03 to 0.11 g). Nineteen different polymers and 10 pigments, including polyester (100% of animals), high-density polyethylene (50%) and polypropylene (50%) were identified. BPA, PTA and PET were detected in fat and liver tissues of all animals, while PC was found only in 50%. A major prevalence was registered in the abdominal fat tissue, although only PC compounds were significantly higher in abdominal tissue (p < 0.05), except for free PTA with liver tissue being the most contaminated (p < 0.05). Microplastics and additives surely impact the health status of turtles that showed gastrointestinal impairment and an important level of contamination in tissues. Graphical abstrac

Gemcitabine as frontline treatment for cutaneous T-cell lymphoma: phase II study of 32 patients.

BACKGROUND. Based on the activity of gemcitabine in heavily pretreated patients with cutaneous T-cell lymphoma (CTCL), the objective of the current study was to determine the role of gemcitabine in the treatment of patients with advanced, untreated CTCL. METHODS. Between June 2002 and February 2004, 32 untreated patients with mycosis fungoides (MF) (n = 26 patients); peripheral T-cell lymphoma, unspecified (PTCLU) with exclusive skin involvement (n = 5 patients); and Sezary syndrome (SS) (n = 1 patient) were enrolled in a 7-institution, Phase II trial and treated with gemcitabine. This drug was given on Days 1, 8, and 15 of a 28-day schedule at a dose of 1200 mg/m2 intravenously over 30 minutes for a total of 6 cycles. RESULTS. Of the 32 patients studied, 7 (22%) achieved a complete response (CR) and 17 (53%) achieved a partial response (PR), whereas the remaining 8 patients showed no benefit from the treatment. Five of the CRs were confirmed histologically. The CR and PR rates were found to be the same for patients with MF and PTCLU, respectively. The median duration of CR was 10 months (range, 4-22 mos). Treatment appeared to be well tolerated; hematologic toxicity was mild and no nausea/emesis or organ toxicity was noted. CONCLUSIONS. The results of the current Phase II study demonstrate the activity of gemcitabine as a single agent in untreated CTCL patients. Further studies using gemcitabine in combination, either contemporary or sequentially, with other drugs in patients with advanced stage, untreated CTCL are needed