Synthesis and photochromic properties of a bis(diarylethene)-naphthopyran hybrid

The synthesis and photochromic properties of a triphotochromic molecule consisting of one naphthopyran flanked by two diarylethene units investigated by UV-Visible and NMR spectroscopies are reported. Six different states resulting from the open/closed naphthopyran associated with one or two open/cyclized diarylethenes have been characterized. Switching of the naphthopyran group is possible, independently of the state of the diarylethene groups, permitting the controlled generation of electronically connected diarylethene groups. However, the diarylethene groups cannot be closed if the naphthopyran group is open

Découverte de vestiges funéraires laténiens à Saint-Ferjeux « La Canotte » (Haute-Saône)

Cet article est une présentation d’une sépulture laténienne à incinération découverte récemment à Saint-Ferjeux (Haute-Saône), au cours d’un diagnostic archéologique. Le dépôt funéraire est constitué entre autres de restes osseux incinérés et d’objets d’accompagnement variés, datant de la fin de La Tène C2, tout début de La Tène D1.This paper presents a cremation burial dating from the La Tène period recently discovered at Saint-Ferjeux (Haut-Saône) during an archaeological evaluation. The burial consists of cremated remains and various grave goods dating from the end of the La Tène C2 and the beginning and the La Tène D1 period.Dieser Artikel behandelt ein latènezeitliches Brandgrab, das kürzlich in Saint-Ferjeux (Departement Haute-Saône) bei einer archäologischen Voruntersuchung entdeckt wurde. Das Grab enthielt neben verbrannten Knochenresten verschiedene Grabbeigaben aus der späten Latène C2, oder der frühen Latène D1 Zeit

Isolation of secondary metabolites from Geranium molle L. with anticancer potential

Two flavone glycosides, apigenin-6-C-glucoside (1) and lutelin-6-C-glucoside (2), and an anomeric mixture of 2,3-dygalloyl-4,6-HHDP-D-glucose (3a/3b) were isolated for the first time from Geranium molle L., a medicinal plant used in the folk medicine of northeast of Portugal for the treatment of a variety of ailments, including cancer. The cytotoxic activity of the isolated compounds was assessed against several human tumour cell lines and non-tumour porcine liver primary cells. The anomeric mixture of ellagitannins 3a/3b, with the two anomers showing considerably different hydrophobicities, was found to be significantly cytotoxic against cancer cells, with only moderate hepatotoxicity.This work was supported by European Investment Funds by FEDER/ COMPETE/POCI – Operational Competitiveness and Internationalization Programme, under Project POCI-01-0145-FEDER- 006958 and National Funds by FCT – Portuguese Foundation for Science and Technology under the projects UID/AGR/00690/2013 (CIMO) and UID/QUI/00616/2013 (CQ-VR). V.C. Graça thanks FCT for her grant (SFRH/BD/52542/2014) and L. Barros for her contract. The authors are also grateful to Interreg España-Portugal for financial support through the project 0377_Iberphenol_6_E.info:eu-repo/semantics/publishedVersio

Immune and Genetic Signatures of Breast Carcinomas Triggering Anti-Yo–Associated Paraneoplastic Cerebellar Degeneration

International audienceBackground and Objectives Paraneoplastic cerebellar degeneration (PCD) with anti-Yo antibodies is a cancer-related autoimmune disease directed against neural antigens expressed by tumor cells. A putative trigger of the immune tolerance breakdown is genetic alteration of Yo antigens. We aimed to identify the tumors' genetic and immune specificities involved in Yo-PCD pathogenesis. Methods Using clinicopathologic data, immunofluorescence (IF) imaging, and whole-transcriptome analysis, 22 breast cancers (BCs) associated with Yo-PCD were characterized in terms of oncologic characteristics, genetic alteration of Yo antigens, differential gene expression profiles, and morphofunctional specificities of their in situ antitumor immunity by comparing them with matched control BCs. Results Yo-PCD BCs were invasive carcinoma of no special type, which early metastasized to lymph nodes. They overexpressed human epidermal growth factor receptor 2 (HER2) but were hormone receptor negative. All Yo-PCD BCs carried at least 1 genetic alteration (variation or gain in copy number) on CDR2L, encoding the main Yo antigen that was found aberrantly overexpressed in Yo-PCD BCs. Analysis of the differentially expressed genes found 615 upregulated and 54 downregulated genes in Yo-PCD BCs compared with HER2-driven control BCs without PCD. Ontology enrichment analysis found significantly upregulated adaptive immune response pathways in Yo-PCD BCs. IF imaging confirmed an intense immune infiltration with an overwhelming predominance of immunoglobulin G-plasma cells. Discussion These data confirm the role of genetic alterations of Yo antigens in triggering the immune tolerance breakdown but also outline a specific biomolecular profile in Yo-PCD BCs, suggesting a cancer-specific pathogenesis

The first cyclopentadienyl complex of uranyl

The U(IV) linear pentacyano metallocene [U(C5Me5)2(CN)5] [NEt4]3 reacted with 2 molar equivalents of pyridine N-oxide in THF or acetonitrile to give the U(VI) complex [UO2(C5Me5)(CN)3][NEt4]2, the first uranyl species containing the cyclopentadienyl ligand; the crystal structure revealed that the steric effects of the (C5Me5) ligand force the {UO2}2+ ion to deviate from linearity

Central limit theorem and almost sure results for bivariate empirical W 1 distances

International audienceIn this paper we study the behavior of the Wasserstein distance of order 1 (also called Kantorovich distance) between the two marginal empirical measures of a stationary sequence of bi-variate random variables. We give sufficient conditions for the central limit theorem, the compact law of the iterated logarithm and the Maricinkiewicz-Zygmund strong law