25 research outputs found
Antiproliferative and anti-inflammatory activity from aerial parts of Psychotria cupularis (Rubiaceae) / Atividade antiproliferativa e anti-inflamatória das partes aéreas de Psychotria cupularis (Rubiaceae)
The crude extract and fractions of aerial parts from Psychotria cupularis, collected at Camacan (Brazil), were tested for anti-inflammatory and antiproliferative activity. A phytochemical screening indicated the presence of tannins, anthraquinones, triterpenes, steroids and flavonoids. The crude extract and fractions inhibited the ear oedema in mice between 50.2 to 87.2% and the myeloperoxidase enzyme activity between 51.6 to 97.1%. The butanolic and ethyl acetate fractions was active against glioma, breast, ovary, kidney, colon and leukaemia cell line (IG50 = 4.3 to 16.9 ?g/mL).Â
Preliminary studies on gastric anti-ulcerogenic effects of Averrhoa carambola in rats
El potencial antiúlcera del extracto hidroalcohólico de las hojas de Averrhoa carambola (ACE) fue investigado en los modelos experimentales de úlcera: lesiones inducidas por etanol acidificado, indomethacin y estrés agudo. ACE a las dosis de 800 y 1200 mg/Kg, sólo mostró actividad antiúlcera significante en el modelo inducido por etanol-acidificado. ACE en modelos experimentales de ulcera inducidos por la indometacina y por el estrés agudo no han demonstrado effectividad. Los resultados indican que la actividad antiúlcera del extracto es baja y presenta diferentes mecanismos de acción.In this study we investigated the anti-ulcerogenic potential of the water-alcohol extract of leaves of Averrhoa carambola (ACE). The acute effects of ACE administered by oral gavage on anti-ulcer activity were investigated in the following ulcer models in rats: lesions induced by acidified ethanol, indomethacin and acute stress. ACE, at doses of 800 and 1200 mg/Kg, p.o., only showed significant anti-ulcer activity in the acidified-ethanol-induced ulcer model in rats. ACE tested by indomethacin and acute stress ulcerogenic models did not show this activity. The results suggest low anti-ulcer activity with different mechanisms of action for the anti-ulcerogenic activity observed for ACE.Colegio de Farmacéuticos de la Provincia de Buenos Aire
Preliminary studies on gastric anti-ulcerogenic effects of Averrhoa carambola in rats
El potencial antiúlcera del extracto hidroalcohólico de las hojas de Averrhoa carambola (ACE) fue investigado en los modelos experimentales de úlcera: lesiones inducidas por etanol acidificado, indomethacin y estrés agudo. ACE a las dosis de 800 y 1200 mg/Kg, sólo mostró actividad antiúlcera significante en el modelo inducido por etanol-acidificado. ACE en modelos experimentales de ulcera inducidos por la indometacina y por el estrés agudo no han demonstrado effectividad. Los resultados indican que la actividad antiúlcera del extracto es baja y presenta diferentes mecanismos de acción.In this study we investigated the anti-ulcerogenic potential of the water-alcohol extract of leaves of Averrhoa carambola (ACE). The acute effects of ACE administered by oral gavage on anti-ulcer activity were investigated in the following ulcer models in rats: lesions induced by acidified ethanol, indomethacin and acute stress. ACE, at doses of 800 and 1200 mg/Kg, p.o., only showed significant anti-ulcer activity in the acidified-ethanol-induced ulcer model in rats. ACE tested by indomethacin and acute stress ulcerogenic models did not show this activity. The results suggest low anti-ulcer activity with different mechanisms of action for the anti-ulcerogenic activity observed for ACE.Colegio de Farmacéuticos de la Provincia de Buenos Aire