Meta-analysis of death and myocardial infarction in the DEFINE-FLAIR and iFR-SWEDEHEART trials: a hypothesis generating note of caution

In patients with coronary heart disease, revascularization can improve symptoms and in certain high-risk subgroups may improve prognosis. Coronary angiography provides anatomical information and the physiological significance of a stenosis can be determined using fractional flow reserve (FFR). Decisions on the need for and mode of revascularization can be optimized using FFR, however this involves administering adenosine to induce hyperemia. Generally, this test is well tolerated, but in some healthcare systems adenosine is either not licensed, unavailable, or expensive, limiting the use of FFR-guided management

Measurements of Pilot Time Delay as Influenced by Controller Characteristics and Vehicles Time Delays

A study to measure and compare pilot time delay when using a space shuttle rotational hand controller and a more conventional control stick was conducted at NASA Ames Research Center's Dryden Flight Research Facility. The space shuttle controller has a palm pivot in the pitch axis. The more conventional controller used was a general-purpose engineering simulator stick that has a pivot length between that of a typical aircraft center stick and a sidestick. Measurements of the pilot's effective time delay were obtained through a first-order, closed-loop, compensatory tracking task in pitch. The tasks were implemented through a space shuttle cockpit simulator and a critical task tester device. The study consisted of 450 data runs with four test pilots and one nonpilot, and used three control stick configurations and two system delays. Results showed that the heavier conventional stick had the lowest pilot effective time delays associated with it, whereas the shuttle and light conventional sticks each had similar higher pilot time delay characteristics. It was also determined that each control stick showed an increase in pilot time delay when the total system delay was increased

Handling qualities aspects of NASA YF-12 flight experience

The handling qualities of the YF-12 airplane as observed during NASA research flights over the past five years were reviewed. Aircraft behavior during takeoff, acceleration, climb, cruise, descent, and landing are discussed. Pilot comments on the various flight phases and tasks are presented. Handling qualities parameters such as period, damping, amplitude ratios, roll-yaw coupling, and flight path response sensitivity are compared to existing and proposed handling qualities criteria. The influence of the propulsion systems, stability augmentation, autopilot systems, atmospheric gusts, and temperature changes are also discussed. YF-12 experience correlates well with flying qualities criteria, except for longitudinal short period damping, where existing and proposed criteria appear to be more stringent than necessary

Adaptive Measurements in the Optical Quantum Information Laboratory

Adaptive techniques make practical many quantum measurements that would otherwise be beyond current laboratory capabilities. For example: they allow discrimination of nonorthogonal states with a probability of error equal to the Helstrom bound; they allow measurement of the phase of a quantum oscillator with accuracy approaching (or in some cases attaining) the Heisenberg limit; and they allow estimation of phase in interferometry with a variance scaling at the Heisenberg limit, using only single qubit measurement and control. Each of these examples has close links with quantum information, in particular experimental optical quantum information: the first is a basic quantum communication protocol; the second has potential application in linear optical quantum computing; the third uses an adaptive protocol inspired by the quantum phase estimation algorithm. We discuss each of these examples, and their implementation in the laboratory, but concentrate upon the last, which was published most recently [Higgins {\em et al.}, Nature vol. 450, p. 393, 2007].Comment: 12 pages, invited paper to be published in IEEE Journal of Selected Topics in Quantum Electronics: Quantum Communications and Information Scienc

Quantum Charged Spinning Particles in a Strong Magnetic Field (a Quantal Guiding Center Theory)

A quantal guiding center theory allowing to systematically study the separation of the different time scale behaviours of a quantum charged spinning particle moving in an external inhomogeneous magnetic filed is presented. A suitable set of operators adapting to the canonical structure of the problem and generalizing the kinematical momenta and guiding center operators of a particle coupled to a homogenous magnetic filed is constructed. The Pauli Hamiltonian rewrites in this way as a power series in the magnetic length $l_B= \sqrt{\hbar c/eB}$ making the problem amenable to a perturbative analysis. The first two terms of the series are explicitly constructed. The effective adiabatic dynamics turns to be in coupling with a gauge filed and a scalar potential. The mechanism producing such magnetic-induced geometric-magnetism is investigated in some detail.Comment: LaTeX (epsfig macros), 27 pages, 2 figures include

Ferrotoroidic Moment as a Quantum Geometric Phase

We present a geometric characterization of the ferrotoroidic moment in terms of a set of Abelian Berry phases. We also introduce a fundamental complex quantity which provides an alternative way to calculate the ferrotoroidic moment and its moments, and is derived from a second order tensor. This geometric framework defines a natural computational approach for density functional and many-body theories

Towards a grid-enabled simulation framework for nano-CMOS electronics

The electronics design industry is facing major challenges as transistors continue to decrease in size. The next generation of devices will be so small that the position of individual atoms will affect their behaviour. This will cause the transistors on a chip to have highly variable characteristics, which in turn will impact circuit and system design tools. The EPSRC project "Meeting the Design Challenges of Nano-CMOS Electronics" (Nana-CMOS) has been funded to explore this area. In this paper, we describe the distributed data-management and computing framework under development within Nano-CMOS. A key aspect of this framework is the need for robust and reliable security mechanisms that support distributed electronics design groups who wish to collaborate by sharing designs, simulations, workflows, datasets and computation resources. This paper presents the system design, and an early prototype of the project which has been useful in helping us to understand the benefits of such a grid infrastructure. In particular, we also present two typical use cases: user authentication, and execution of large-scale device simulations

Berry phase and quantized Hall effect in three-dimension

We consider Bloch electrons in the electromagnetic field and argue the relation between the Berry phase and the quantized Hall conductivity in three-dimension. The Berry phase we consider here is induced by the adiabatic change of the time-dependent vector potential. The relation has been shown in two-dimensional systems, and we generalize the relation in three-dimensional systems.Comment: corrected some typos. Accepted for publication in J. Phys. Soc. Jp

Why do gallium clusters have a higher melting point than the bulk?

Density functional molecular dynamical simulations have been performed on Ga$_{17}$ and Ga$_{13}$ clusters to understand the recently observed higher-than-bulk melting temperatures in small gallium clusters [Breaux {\em et al.}, Phys. Rev. Lett. {\bf 91}, 215508 (2003)]. The specific-heat curve, calculated with the multiple-histogram technique, shows the melting temperature to be well above the bulk melting point of 303 K, viz. around 650 K and 1400 K for Ga$_{17}$ and Ga$_{13}$, respectively. The higher-than-bulk melting temperatures are attributed mainly to the covalent bonding in these clusters, in contrast with the covalent-metallic bonding in the bulk.Comment: 4 pages, including 6 figures. accepted for publication in Phys. Rev. Let