Dis-orientation: spatial abilities performance in London

This report investigates the relation of the Spatial Configuration with the orientation performance of the individual in urban Navigation. Spatial Orientation is defined as a function of the mind involving ‘awareness of place’ in the environment, and is a key aspect of Navigation in terms of maintaining a sense of where the subject is relative to its goal as it is moving. The aim of this thesis is to shed light on Spatial Orientation performance and how it is linked to spatial and syntactic properties of space. This topic is intrinsic in the Space Syntax theory due its fundamental relation between spatiality and human activity. The research method used was a set of questionnaires done in London specifically in Covent Garden and Soho areas, asking people to point to five Landmarks and North. The results were overlaid with spatial analysis and compared through directions diagrams and statistical data analysis. The findings show relations between the Spatial Configuration and the given Landmarks directions with grid angularity, grid visibility and familiarity with the place. The discussion is developed through the research findings and theories of spatial Navigation, Wayfinding and spatial cognition, putting forward varied interpretations related with the research topic and the selected areas. The report concludes that the Spatial Orientation in Soho and Covent Garden is determined by Spatial Configuration of the place and related with the grid structure. Furthermore, it is argued that the Navigation System in Central London is based in Path Integration rather than Landmark recognition and it is dependant on the familiarity of the subject with the Space of Navigation

Patterns and Mechanisms of Ancestral Histone Protein Inheritance in Budding Yeast

Tracking of ancestral histone proteins over multiple generations of genome replication in yeast reveals that old histones move along genes from 3′ toward 5′ over time, and that maternal histones move up to around 400 bp during genomic replication

Conditional growth of Escherichia coli caused by expression of vaccinia virus DNA topoisomerase I.

Active vaccinia virus topoisomerase I is expressed in Escherichia coli containing plasmid p1940 (S. Shuman, M. Golder, and B. Moss, J. Biol. Chem. 263:16401-16407, 1988). Growth curves showed a decline of 2 to 3 logs in the number of viable cells at 42 degrees C after shift from 30 degrees C because of increased vaccinia virus topoisomerase I level. Mutations in the gyrA and gyrB genes allowed cells to grow equally well at 42 and 30 degrees C. The presence of gyrase inhibitor also improved growth at 42 degrees C

SMART DOMOTIX: IMPLEMENTATION OF LOW ENERGY RADIO FREQUENCY TO HOME AUTOMATION

Home automation is a well-known concept since the rise of information technologies. Today, with the increasing availability of internet access, implementation of home automation system will be practical, however today's commercially available home automation systems are expensive, not compatible with other technologies or not user friendly (prior knowledge to electronics is required in order to use the system). This study aims to design, develop and implement a home automation system which is user-friendly, easily deployable and has a plug-and-play capability. The system implementation is an internet-based and has four main parts: smart plugs, user interface, server and main controller. The appliances will be directly connected to the smart plugs. The smart plugs are responsible for the actuation and power monitoring of these appliances. The user interface, namely the web app and the mobile app can be accessed by the users allowing them to control the system. The instructions from the users and informations from the smart plugs are stored in the server. The server acts as the communication medium between the appliances and the users. The main controller on the other hand, communicates to both the smart plugs and the server. It accesses the instructions from the server and controls the smart plugs. Through the survey results as shown in Figure 1, we have confirmed that indeed, the system we have developed is user-friendly and is plug-and-play, although further improvements with the size of the smart plug and the speed of the system were highly recommended by the respondents. Figure 2 We also conducted power accuracy tests of the smart plugs and computed for the percent error of the power readings compared to a Voltcraft (comercial power meter) and got a result of an average of 2.27% error which is close enough to commercially available energy meters. Though further improvements can be added to the such as using of much accurate power meters to achieve a more error free results. Also the smart plug can be fabricated using Surface mount devices to minimize the size of the plugs

Dios, ser humano, mundo : entre la filosofía y la teología

Dios, ser humano y mundo son los tres grandes temas del pensamiento occidental. Estas tres ideas no constituyen solamente el objeto de las metafísicas especiales, sino que también conforman el núcleo problemático de la teología; aunque los acentos y enfoques varíen entre los diversos abordajes. Esto es así pues Dios, ser humano y mundo, en sus relaciones múltiples, plantean las cuestiones fundamentales que desvelan, condicionan y transforman nuestra existencia: la existencia de un ser humano en el mundo ante Dios o ante su ausencia. La tradición del pensamiento occidental, en sus diversas vertientes, ha intentado pensar esta compleja articulación hasta nuestros días. Este libro busca abordar de forma interdisciplinaria estas problemáticas comunes a la filosofía y a la teología desde un diálogo abierto entre los dos saberes, buscando encontrar aquellas convergencias y divergencias que permitan enriquecer sus propuestas en virtud de su responsabilidad teórica y práctica.Libros de Cátedr

Table_1_Non-severe thermal burn injuries induce long-lasting downregulation of gene expression in cortical excitatory neurons and microglia.PDF

Burn injuries are devastating traumas, often leading to life-long consequences that extend beyond the observable burn scar. In the context of the nervous system, burn injury patients commonly develop chronic neurological disorders and have been suggested to have impaired motor cortex function, but the long-lasting impact on neurons and glia in the brain is unknown. Using a mouse model of non-severe burn injury, excitatory and inhibitory neurons in the primary motor cortex were labelled with fluorescent proteins using adeno-associated viruses (AAVs). A total of 5 weeks following the burn injury, virus labelled excitatory and inhibitory neurons were isolated using fluorescence-activated cell sorting (FACS). In addition, microglia and astrocytes from the remaining cortical tissue caudal to the motor cortex were immunolabelled and isolated with FACS. Whole transcriptome RNA-sequencing was used to identify any long-lasting changes to gene expression in the different cell types. RNA-seq analysis showed changes to the expression of a small number of genes with known functions in excitatory neurons and microglia, but not in inhibitory neurons or astrocytes. Specifically, genes related to GABA-A receptors in excitatory neurons and several cellular functions in microglia were found to be downregulated in burn injured mice. These findings suggest that non-severe burn injuries lead to long lasting transcriptomic changes in the brain, but only in specific cell types. Our findings provide a broad overview of the long-lasting impact of burn injuries on the central nervous system which may help identify potential therapeutic targets to prevent neurological dysfunction in burn patients.</p