Resultater fra den strategisk analyse af en fast forbindelse mellem Helsingør og Helsingborg: Artikel

Vejdirektoratet, Trafik-, Bygge- og Boligstyrelsen og Trafikverket afsluttede i januar 2021 en strategisk analyse af en fast forbindelse mellem Helsingør og Helsingborg (HH-forbindelsen). En fast vejforbindelse og en baneforbindelse for persontog kan anlægges som to adskilte, borede tunneller under Øresund. Anlægsomkostningerne vurderes at være mellem 21 og 23 mia. danske kr. for en ren vejforbindelse, mens vej og baneforbindelse samlet vurderes at koste 41-42 mia. danske kr. Forbindelsen forventes at få en vejtrafik på ca. 15.000 køretøjer og ca. 19.000 rejsende med kollektiv trafik pr. hverdagsdøgn i 2040.Samfundsøkonomiske beregninger for hhv. Danmark og Sverige peger på at en ren vejforbindelse er samfundsøkonomisk rentabel og kan finansieres af brugerne af den nye forbindelse. En vej- og baneforbindelse får dog en intern rente på 2,9% og en nettoværdikvote på -0,2 i hhv. Danske og Svenske analyser. Den bliver dermed ikke samfundsøkonomisk rentabel og får behov for væsentlige tilskud til finansieringen ud over bidraget fra brugerfinansieringen

Strategisk analyse af en fast forbindelse mellem Helsingør og Helsingborg.

Vejdirektoratet, Trafik-, Bygge og Boligstyrelsen og Trafikverket er, med støtte fra Interreg Øresund-Kattegat-Skagerrak, i gang med en strategisk analyse af en fast forbindelse mellem Helsingør og Helsingborg. Frem til august 2019 har der været fokuseret på tidligere undersøgelser, udviklingen i transportmønstrene på tværs af Øresund, og forskelle og ligheder i modelgrundlag og metoder mellem Danmark og Sverige. Den samlede analyse forventes færdig inden udgangen af 2020.&nbsp

Building a sustainable region? The fourth city region

There are three are three official city regions in Sweden at the moment. This thesis investigates the process to create a fourth, the development of Linköping and Norrköping, twin cities strategically placed in reach of the other three metropolitan areas. Strategic planning implies a perspective where different instruments and indicators which complements or contradicts each other. The importance of the collaboration between different plans could have synergetic or cumulative effects. Urban development is a progress over a long time period and the infrastructural projects will have even longer effects. Environmental assessments like EIA and SEA and other methods, which are used in different parts of strategic planning, aims to identify and reveal goal conflicts. They also discuss alternatives and unsustainable effects as a base for decision making. Sustainable development can be seen as a goal or a process, both perspectives is highly dependent on of infrastructure and other physical structures in the society. The results of this study express an urgency of transition towards a more cautious attitude towards the future development. The alignment of regional development that can be followed through out the investigated plans shows a strong focus of economic growth, rather than finding sustainable solutions

Building a sustainable region? The fourth city region

There are three are three official city regions in Sweden at the moment. This thesis investigates the process to create a fourth, the development of Linköping and Norrköping, twin cities strategically placed in reach of the other three metropolitan areas. Strategic planning implies a perspective where different instruments and indicators which complements or contradicts each other. The importance of the collaboration between different plans could have synergetic or cumulative effects. Urban development is a progress over a long time period and the infrastructural projects will have even longer effects. Environmental assessments like EIA and SEA and other methods, which are used in different parts of strategic planning, aims to identify and reveal goal conflicts. They also discuss alternatives and unsustainable effects as a base for decision making. Sustainable development can be seen as a goal or a process, both perspectives is highly dependent on of infrastructure and other physical structures in the society. The results of this study express an urgency of transition towards a more cautious attitude towards the future development. The alignment of regional development that can be followed through out the investigated plans shows a strong focus of economic growth, rather than finding sustainable solutions

The development of a GPR44 targeting radioligand [11C]AZ12204657 for in vivo assessment of beta cell mass.

BACKGROUND: The G-protein-coupled receptor 44 (GPR44) is a beta cell-restricted target that may serve as a marker for beta cell mass (BCM) given the development of a suitable PET ligand. METHODS: The binding characteristics of the selected candidate, AZ12204657, at human GPR44 were determined using in vitro ligand binding assays. AZ12204657 was radiolabeled using 11C- or 3H-labeled methyl iodide ([11C/3H]CH3I) in one step, and the conversion of [11C/3H]CH3I to the radiolabeled product [11C/3H]AZ12204657 was quantitative. The specificity of radioligand binding to GPR44 and the selectivity for beta cells were evaluated by in vitro binding studies on pancreatic sections from human and non-human primates as well as on homogenates from endocrine and exocrine pancreatic compartments. RESULTS: The radiochemical purity of the resulting radioligand [11C]AZ12204657 was > 98%, with high molar activity (MA), 1351 ± 575 GBq/μmol (n = 18). The radiochemical purity of [3H]AZ12204657 was > 99% with MA of 2 GBq/μmol. Pancreatic binding of [11C/3H]AZ12204657 was co-localized with insulin-positive islets of Langerhans in non-diabetic individuals and individuals with type 2 diabetes (T2D). The binding of [11C]AZ12204657 to GPR44 was > 10 times higher in islet homogenates compared to exocrine homogenates. In human islets of Langerhans GPR44 was co-expressed with insulin, but not glucagon as assessed by co-staining and confocal microscopy. CONCLUSION: We radiolabeled [11C]AZ12204657, a potential PET radioligand for the beta cell-restricted protein GPR44. In vitro evaluation demonstrated that [3H]AZ12204657 and [11C]AZ12204657 selectively target pancreatic beta cells. [11C]AZ12204657 has promising properties as a marker for human BCM