Minimally-destructive detection of magnetically-trapped atoms using frequency-synthesised light

We present a technique for atomic density measurements by the off-resonant phase-shift induced on a two-frequency, coherently-synthesised light beam. We have used this scheme to measure the column density of a magnetically trapped atom cloud and to monitor oscillations of the cloud in real time by making over a hundred non-destructive local density measurments. For measurements using pulses of 10,000-100,000 photons lasting ~10 microsecond, the precision is limited by statistics of the photons and the photodiode avalanche. We explore the relationship between measurement precision and the unwanted loss of atoms from the trap and introduce a figure of merit that characterises it. This method can be used to probe the density of a BEC with minimal disturbance of its phase.Comment: Submitted to New Journal of Physic

Trans-arterial therapy for Fibrolamellar carcinoma: A case report and literature review

Introduction: Fibrolamellar carcinoma (FLC) is a rare pathologically distinct primary liver cancer. Surgical resection is the only treatment associated with prolonged survival. Trans-arterial embolization (TAE), which is a recognised treatment for hepatocellular carcinoma has been used to treat FLC. We present a case and performed a literature review of patients with FLC treated with TAE. Case presentation: We present a 19-year old female with a large potentially resectable FLC which was initially treated with trans-arterial chemo-embolization (TACE) with drug eluting beads. The TACE was followed by surgical resection. Histology confirmed tumour necrosis related to the previous TACE. Discussion & literature review: We identified seven case reports and one case series of TAE for FLC. TAE was either used as a neo-adjuvant therapy to facilitate subsequent tumour resection or as a palliative treatment modality. We propose an algorithm for the treatment of FLC that includes TAE. Conclusion: The rarity of FLC and the paucity of data precludes establishing clear evidence-based standards of care. We propose an algorithm for the treatment of FLC. The establishment of an international registry may facilitate the collection of better quality evidence

Adapting Quality Assurance to Adaptive Systems: The Scenario Coevolution Paradigm

From formal and practical analysis, we identify new challenges that self-adaptive systems pose to the process of quality assurance. When tackling these, the effort spent on various tasks in the process of software engineering is naturally re-distributed. We claim that all steps related to testing need to become self-adaptive to match the capabilities of the self-adaptive system-under-test. Otherwise, the adaptive system's behavior might elude traditional variants of quality assurance. We thus propose the paradigm of scenario coevolution, which describes a pool of test cases and other constraints on system behavior that evolves in parallel to the (in part autonomous) development of behavior in the system-under-test. Scenario coevolution offers a simple structure for the organization of adaptive testing that allows for both human-controlled and autonomous intervention, supporting software engineering for adaptive systems on a procedural as well as technical level.Comment: 17 pages, published at ISOLA 201

Carbon brainprint - An estimate of the intellectual contribution of research institutions to reducing greenhouse gas emissions

This is the accepted manuscript of a paper published in Process Safety and Environmental Protection (Chatterton J, et al., Process Safety and Environmental Protection, 2015, 96, 74-81, doi:10.1016/j.psep.2015.04.008). The final version is available at http://dx.doi.org/10.1016/j.psep.2015.04.008Research and innovation have considerable, currently unquantified potential to reduce greenhouse gas emissions by, for example, increasing energy efficiency. Furthermore, the process of knowledge transfer in itself can have a significant impact on reducing emissions, by promoting awareness and behavioural change. The concept of the ‘carbon brainprint’ was proposed to convey the intellectual contribution of higher education institutions to the reduction of greenhouse gas emissions by other parties through research and teaching/training activities. This paper describes an investigation of the feasibility of quantifying the carbon brainprint, through six case studies. The potential brainprint of higher education institutes is shown to be significant: up to 500 kt CO2e/year for one project. The most difficult aspect is attributing the brainprint among multiple participants in joint projects.The Carbon Brainprint project was supported by the Higher Education Funding Council for England (HEFCE) under its Leading Sustainable Development in Higher Education programme, with support for case studies from Santander Universities. HEFCE, Research Councils UK and the Carbon Trust were members of the Steering Committee, which provided guidance, but did not direct the research. The Carbon Trust also advised on best practice in carbon footprinting. We are grateful to the many university staff at Cranfield, Cambridge and Reading Universities who shared their work with us so enthusiastically. We also thank the external partners and clients for the projects on which these case studies are based: Rolls-Royce plc, the ETI NOVA consortium, IGD, the Environment Agency, Esso, Repsol YPF, Carnego Systems Ltd. and Newera Controls Ltd

Les Houches 2015: Physics at TeV colliders - new physics working group report

We present the activities of the 'New Physics' working group for the 'Physics at TeV Colliders' workshop (Les Houches, France, 1-19 June, 2015). Our report includes new physics studies connected with the Higgs boson and its properties, direct search strategies, reinterpretation of the LHC results in the building of viable models and new computational tool developments. Important signatures for searches for natural new physics at the LHC and new assessments of the interplay between direct dark matter searches and the LHC are also considered.Comment: Proceedings of the New Physics Working Group of the 2015 Les Houches Workshop, Physics at TeV Colliders, Les Houches 1-19 June 2015. 197 page

A generic testing framework for agent-based simulation models

International audienceAgent-based modelling and simulation (ABMS) had an increasing attention during the last decade. However, the weak validation and verification of agent-based simulation models makes ABMS hard to trust. There is no comprehensive tool set for verification and validation of agent-based simulation models, which demonstrates that inaccuracies exist and/or reveals the existing errors in the model. Moreover, on the practical side, many ABMS frameworks are in use. In this sense, we designed and developed a generic testing framework for agent-based simulation models to conduct validation and verification of models. This paper presents our testing framework in detail and demonstrates its effectiveness by showing its applicability on a realistic agent-based simulation case study