375 research outputs found

    Tibolone and Bone

    Get PDF

    The constructive evolution of taste in Astyanax cavefish: A review

    Get PDF
    Animals inhabiting subterranean environments tend to evolve a constellation of ‘regressive’ and ‘constructive’ features. Regressive traits like vision and pigmentation are reduced or lost in derived organisms. In contrast, constructive traits like non-visual sensation, are commonly augmented and evolving under strong selection. Numerous studies have examined the genetic, developmental and molecular bases for regressive traits, while constructive traits have received less attention. A key constructive sensory feature in cave animals is the gustatory system which is likely useful for animals living in complete darkness, given the need to secure food for survival. Interestingly, despite having been studied for decades in the Mexican tetra, Astyanax mexicanus, much remains unknown regarding the biological basis, and adaptive relevance, of taste system evolution in cave morphs. Here, we present a brief review of taste system research in this system, conducted over the past ~90  years. We underscore key differences in gustation between cave and surface fish that reside at the levels of anatomy, perception and behavior. From this review, we sought to identify key knowledge gaps in our understanding of constructive taste system evolution. Future studies will provide further insights to the nature of constructive trait evolution by determining if constructive and regressive traits evolve through similar or different genetic and developmental mechanisms, and provide an essential case study for examining convergence of constructive traits across geographically distinct populations

    Tibolone and bone

    Get PDF

    Unique Multiorganizational Collaborative Proves Effective in Delivering 2014 Farm Bill Education

    Get PDF
    The Agricultural Act of 2014 is critical to the economic safety net for U.S. producers. This act represented a major change in philosophy, requiring producers to make key decisions about their options on the basis of risk management. To add to the complexity of the issue, the time period for delivering applicable education to landowners before sign-up deadlines was relatively short. This article highlights a unique multiorganizational statewide approach to delivering the applicable education. It involved University of Minnesota Extension, the Center for Farm Financial Management, the U.S. Department of Agriculture, and banks and resulted in substantive evaluative outcomes

    Biology - Cruise Report No. M51, Leg 1

    Get PDF
    "Ostatlantik-Mittelmeer-Schwarzes Meer

    Liquid flyback booster pre-phase: A study assessment

    Get PDF
    The concept of a flyback booster has been around since early in the shuttle program. The original two-stage shuttle concepts used a manned flyback booster. These boosters were eliminated from the program for funding and size reasons. The current shuttle uses two Redesigned Solid Rocket Motors (RSRM's), which are recovered and refurbished after each flight; this is one of the major cost factors of the program. Replacement options have been studied over the past ten years. The conclusion reached by the most recent study is that the liquid flyback booster (LFBB) is the only competitive option from a life-cycle cost perspective. The purpose of this study was to assess the feasibility and practicality of LFBB's. The study provides an expansion of the recommendations made during the aforementioned study. The primary benefits are the potential for enhanced reusability and a reduction of recurring costs. The potential savings in vehicle turnaround could offset the up-front costs. Development of LFBB's requires a commitment to the shuttle program for 20 to 30 years. LFBB's also offer enhanced safety and abort capabilities. Currently, any failure of an RSRM can be considered catastrophic, since there are no intact abort capabilities during the burn of the RSRM's. The performance goal of the LFBB's was to lift a fully loaded orbiter under optimal conditions, so as not to be the limiting factor of the performance capability of the shuttle. In addition, a final benefit is the availability of growth paths for applications other than shuttle

    Liquid Flyback Booster Pre-Phase A Study Assessment

    Get PDF
    Mw concept of a flyback booster has been around since early in the Shuttle program. The original two-stage Shuttle concepts used a manned flyback booster. These boosters were eliminated from the program for funding and size reasons. The current Shuttle uses two Redesigned Solid Rocket Motors (RSRMs), which are recovered and refurbished after each flight; this is one of the major cost factors of the program. Replacement options have been studied over the past ten years. The conclusion reached by the most recent study is that the liquid flyback booster (LFBB) is the only competitive option from a life-cycle cost perspective. The purpose of this study was to assess the feasibility and practicality of LFBBs. The study provides an expansion of the recommendations made during the during the aforementioned study. The primary benefits are the potential for enhanced reusability and a reuction of recurring costs. The potential savings in vehicle turnaround could offset the up-front costs. Development of LFBBs requires a commitment to the Shuttle program for 20 to 30 years. LFBBs also offer enhanced safety and abort capabilities. Currently, any failure of an RSRM can be considered catastrophic since them we no intact abort capabilities during the burn of the RSRMS. The performance goal of the LFBBs was to lift a fully loaded Orbiter under optimal conditions, so as not to be the limiting factor of the performance capability of the Shuttle. In addition, a final benefit is the availability of growth paths for applications other than the Shuttle
    • …
    corecore