Caffeine affects the biological responses of human hematopoietic cells of myeloid lineage via downregulation of the mTOR pathway and xanthine oxidase activity

Correction of human myeloid cell function is crucial for the prevention of inflammatory and allergic reactions as well as leukaemia progression. Caffeine, a naturally occurring food component, is known to display anti-inflammatory effects which have previously been ascribed largely to its inhibitory actions on phosphodiesterase. However, more recent studies suggest an additional role in affecting the activity of the mammalian target of rapamycin (mTOR), a master regulator of myeloid cell translational pathways, although detailed molecular events underlying its mode of action have not been elucidated. Here, we report the cellular uptake of caffeine, without metabolisation, by healthy and malignant hematopoietic myeloid cells including monocytes, basophils and primary acute myeloid leukaemia mononuclear blasts. Unmodified caffeine downregulated mTOR signalling, which affected glycolysis and the release of pro-inflammatory/pro-angiogenic cytokines as well as other inflammatory mediators. In monocytes, the effects of caffeine were potentiated by its ability to inhibit xanthine oxidase, an enzyme which plays a central role in human purine catabolism by generating uric acid. In basophils, caffeine also increased intracellular cyclic adenosine monophosphate (cAMP) levels which further enhanced its inhibitory action on mTOR. These results demonstrate an important mode of pharmacological action of caffeine with potentially wide-ranging therapeutic impact for treating non-infectious disorders of the human immune system, where it could be applied directly to inflammatory cells

Abstract involutions of algebraic groups and of Kac-Moody groups

Based on the second author's thesis in this article we provide a uniform treatment of abstract involutions of algebraic groups and of Kac-Moody groups using twin buildings, RGD systems, and twisted involutions of Coxeter groups. Notably we simultaneously generalize the double coset decompositions established by Springer and by Helminck-Wang for algebraic groups and by Kac-Wang for certain Kac-Moody groups, we analyze the filtration studied by Devillers-Muhlherr in the context of arbitrary involutions, and we answer a structural question on the combinatorics of involutions of twin buildings raised by Bennett-Gramlich-Hoffman-Shpectorov

Elliptic flow in Au+Au collisions at sqrt sNN = 130 GeV

Elliptic flow from nuclear collisions is a hadronic observable sensitive to the early stages of system evolution. We report first results on elliptic flow of charged particles at midrapidity in Au+Au collisions at sqrt[sNN] = 130 GeV using the STAR Time Projection Chamber at the Relativistic Heavy Ion Collider. The elliptic flow signal, v2, averaged over transverse momentum, reaches values of about 6% for relatively peripheral collisions and decreases for the more central collisions. This can be interpreted as the observation of a higher degree of thermalization than at lower collision energies. Pseudorapidity and transverse momentum dependence of elliptic flow are also presented.alle Autoren: K. H. Ackermann19, N. Adams28, C. Adler12, Z. Ahammed27, S. Ahmad28, C. Allgower13, J. Amsbaugh34, M. Anderson6, E. Anderssen17, H. Arnesen3, L. Arnold14, G. S. Averichev10, A. Baldwin16, J. Balewski13, O. Barannikova10,27, L. S. Barnby16, J. Baudot14, M. Beddo1, S. Bekele24, V. V. Belaga10, R. Bellwied35, S. Bennett35, J. Bercovitz17, J. Berger12, W. Betts24, H. Bichsel34, F. Bieser17, L. C. Bland13, M. Bloomer17, C. O. Blyth4, J. Boehm17, B. E. Bonner28, D. Bonnet14, R. Bossingham17, M. Botlo3, A. Boucham30, N. Bouillo30, S. Bouvier30, K. Bradley17, F. P. Brady6, E. S. Braithwaite2, W. Braithwaite2, A. Brandin21, R. L. Brown3, G. Brugalette34, C. Byrd2, H. Caines24, M. Calderón de la Barca Sánchez36, A. Cardenas27, L. Carr34, J. Carroll17, J. Castillo30, B. Caylor17, D. Cebra6, S. Chatopadhyay35, M. L. Chen3, W. Chen3, Y. Chen7, S. P. Chernenko10, M. Cherney9, A. Chikanian36, B. Choi31, J. Chrin9, W. Christie3, J. P. Coffin14, L. Conin30, C. Consiglio3, T. M. Cormier35, J. G. Cramer34, H. J. Crawford5, V. I. Danilov10, D. Dayton3, M. DeMello28, W. S. Deng16, A. A. Derevschikov26, M. Dialinas30, H. Diaz3, P. A. DeYoung8, L. Didenko3, D. Dimassimo3, J. Dioguardi3, W. Dominik32, C. Drancourt30, J. E. Draper6, V. B. Dunin10, J. C. Dunlop36, V. Eckardt19, W. R. Edwards17, L. G. Efimov10, T. Eggert19, V. Emelianov21, J. Engelage5, G. Eppley28, B. Erazmus30, A. Etkin3, P. Fachini29, C. Feliciano3, D. Ferenc6, M. I. Ferguson7, H. Fessler19, E. Finch36, V. Fine3, Y. Fisyak3, D. Flierl12, I. Flores5, K. J. Foley3, D. Fritz17, N. Gagunashvili10, J. Gans36, M. Gazdzicki12, M. Germain14, F. Geurts28, V. Ghazikhanian7, C. Gojak14, J. Grabski33, O. Grachov35, M. Grau3, D. Greiner17, L. Greiner5, V. Grigoriev21, D. Grosnick1, J. Gross9, G. Guilloux30, E. Gushin21, J. Hall35, T. J. Hallman3, D. Hardtke17, G. Harper34, J. W. Harris36, P. He5, M. Heffner6, S. Heppelmann25, T. Herston27, D. Hill1, B. Hippolyte14, A. Hirsch27, E. Hjort27, G. W. Hoffmann31, M. Horsley36, M. Howe34, H. Z. Huang7, T. J. Humanic24, H. Hümmler19, W. Hunt13, J. Hunter17, G. J. Igo7, A. Ishihara31, Yu. I. Ivanshin11, P. Jacobs17, W. W. Jacobs13, S. Jacobson17, R. Jared17, P. Jensen31, I. Johnson17, P. G. Jones4, E. Judd5, M. Kaneta17, M. Kaplan8, D. Keane16, V. P. Kenney23*, A. Khodinov21, J. Klay6, S. R. Klein17, A. Klyachko13, G. Koehler17, A. S. Konstantinov26, V. Kormilitsyne7,26, L. Kotchenda21, I. Kotov24, A. D. Kovalenko10, M. Kramer22, P. Kravtsov21, K. Krueger1, T. Krupien3, P. Kuczewski3, C. Kuhn14, G. J. Kunde36, C. L. Kunz8, R. Kh. Kutuev11, A. A. Kuznetsov10, L. Lakehal-Ayat30, J. Lamas-Valverde28, M. A. C. Lamont4, J. M. Landgraf3, S. Lange12, C. P. Lansdell31, B. Lasiuk36, F. Laue24, A. Lebedev3, T. LeCompte1, W. J. Leonhardt3, V. M. Leontiev26, P. Leszczynski33, M. J. LeVine3, Q. Li35, Q. Li17, Z. Li3, C.-J. Liaw3, J. Lin9, S. J. Lindenbaum22, V. Lindenstruth5, P. J. Lindstrom5, M. A. Lisa24, H. Liu16, T. Ljubicic3, W. J. Llope28, G. LoCurto19, H. Long7, R. S. Longacre3, M. Lopez-Noriega24, D. Lopiano1, W. A. Love3, J. R. Lutz14, D. Lynn3, L. Madansky15§, R. Maier19, R. Majka36, A. Maliszewski33, S. Margetis16, K. Marks17, R. Marstaller19, L. Martin30, J. Marx17, H. S. Matis17, Yu. A. Matulenko26, E. A. Matyushevski10, C. McParland17, T. S. McShane9, J. Meier9, Yu. Melnick26, A. Meschanin26, P. Middlekamp3, N. Mikhalin7,26, B. Miller3, Z. Milosevich8, N. G. Minaev26, B. Minor17, J. Mitchell15, E. Mogavero3, V. A. Moiseenko11, D. Moltz17, C. F. Moore31, V. Morozov17, R. Morse17, M. M. de Moura29, M. G. Munhoz29, G. S. Mutchler28, J. M. Nelson4, P. Nevski3, T. Ngo7, M. Nguyen3, T. Nguyen3, V. A. Nikitin11, L. V. Nogach26, T. Noggle17, B. Norman16, S. B. Nurushev26, T. Nussbaum28, J. Nystrand17, G. Odyniec17, A. Ogawa25, C. A. Ogilvie18, K. Olchanski3, M. Oldenburg19, D. Olson17, G. A. Ososkov10, G. Ott31, D. Padrazo3, G. Paic24, S. U. Pandey35, Y. Panebratsev10, S. Y. Panitkin16, A. I. Pavlinov26, T. Pawlak33, M. Pentia10, V. Perevotchikov3, W. Peryt33, V. A Petrov11, W. Pinganaud30, S. Pirogov7, E. Platner28, J. Pluta33, I. Polk3, N. Porile27, J. Porter3, A. M. Poskanzer17, E. Potrebenikova10, D. Prindle34, C. Pruneau35, J. Puskar-Pasewicz13, G. Rai17, J. Rasson17, O. Ravel30, R. L. Ray31, S. V. Razin10,13, D. Reichhold9, J. Reid34, R. E. Renfordt12, F. Retiere30, A. Ridiger21, J. Riso35, H. G. Ritter17, J. B. Roberts28, D. Roehrich12, O. V. Rogachevski10, J. L. Romero6, C. Roy30, D. Russ8, V. Rykov35, I. Sakrejda17, R. Sanchez7, Z. Sandler7, J. Sandweiss36, P. Sappenfield28, A. C. Saulys3, I. Savin11, J. Schambach31, R. P. Scharenberg27, J. Scheblien3, R. Scheetz3, R. Schlueter17, N. Schmitz19, L. S. Schroeder17, M. Schulz3,19, A. Schüttauf19, J. Sedlmeir3, J. Seger9, D. Seliverstov21, J. Seyboth19, P. Seyboth19, R. Seymour34, E. I. Shakaliev10, K. E. Shestermanov26, Y. Shi7, S. S. Shimanskii10, D. Shuman17, V. S. Shvetcov11, G. Skoro10, N. Smirnov36, L. P. Smykov10, R. Snellings17, K. Solberg13, J. Sowinski13, H. M. Spinka1, B. Srivastava27, E. J. Stephenson13, R. Stock12, A. Stolpovsky35, N. Stone3, R. Stone17, M. Strikhanov21, B. Stringfellow27, H. Stroebele12, C. Struck12, A. A. P. Suaide29, E. Sugarbaker24, C. Suire14, T. J. M. Symons17, J. Takahashi29, A. H. Tang16, A. Tarchini14, J. Tarzian17, J. H. Thomas17, V. Tikhomirov21, A. Szanto de Toledo29, S. Tonse17, T. Trainor34, S. Trentalange7, M. Tokarev10, M. B. Tonjes20, V. Trofimov21, O. Tsai7, K. Turner3, T. Ullrich36, D. G. Underwood1, I. Vakula7, G. Van Buren3, A. M. VanderMolen20, A. Vanyashin17, I. M. Vasilevski11, A. N. Vasiliev26, S. E. Vigdor13, G. Visser5, S. A. Voloshin35, C. Vu17, F. Wang27, H. Ward31, D. Weerasundara34, R. Weidenbach17, R. Wells17, R. Wells24, T. Wenaus3, G. D. Westfall20, J. P. Whitfield8, C. Whitten, Jr.7, H. Wieman17, R. Willson24, K. Wilson35, J. Wirth17, J. Wisdom7, S. W. Wissink13, R. Witt16, J. Wolf17, L. Wood6, N. Xu17, Z. Xu36, A. E. Yakutin26, E. Yamamoto7, J. Yang7, P. Yepes28, A. Yokosawa1, V. I. Yurevich10, Y. V. Zanevski10, J. Zhang17, W. M. Zhang16, J. Zhu34, D. Zimmerman17, R. Zoulkarneev11, and A. N. Zubare

Impact of Radiotherapy, Chemotherapy and Surgery in Multimodal Treatment of Locally Advanced Esophageal Cancer

Objectives: It was the aim of this study to assess our institutional experience with definitive chemoradiation (CRT) versus induction chemotherapy followed by CRT with or without surgery (C-CRT/S) in esophageal cancer. Methods: We retrospectively analyzed 129 institutional patients with locally advanced esophageal cancer who had been treated by either CRT in analogy to the RTOG 8501 trial (n = 78) or C-CRT/S (n = 51). Results: The median, 2-and 5-year overall survival (OS) of the entire collective was 17.6 months, 42 and 24%, respectively, without a significant difference between the CRT and C-CRT/S groups. In C-CRT/S patients, surgery statistically improved the locoregional control (LRC) rates (2-year LRC 73.6 vs. 21.2%; p = 0.003); however, this was translated only into a trend towards improved OS (p = 0.084). The impact of escalated radiation doses (>= 60.0 vs. <60.0 Gy) on LRC was detectable only in T1-3 N0-1 M0 patients of the CRT group (2-year LRC 77.8 vs. 42.3%; p = 0.036). Conclusion: Definitive CRT and a trimodality approach including surgery (C-CRT/S) had a comparable outcome in this unselected patient collective. Surgery and higher radiation doses improve LRC rates in subgroups of patients, respectively, but without effect on OS. Copyright (C) 2012 S. Karger AG, Base

Net charge fluctuations in Au+Au collisions at sqrt[sNN ]=130 GeV

We present the results of charged particle fluctuations measurements in Au+Au collisions at sqrt[sNN ]=130 GeV using the STAR detector. Dynamical fluctuations measurements are presented for inclusive charged particle multiplicities as well as for identified charged pions, kaons, and protons. The net charge dynamical fluctuations are found to be large and negative providing clear evidence that positive and negative charged particle production is correlated within the pseudorapidity range investigated. Correlations are smaller than expected based on model-dependent predictions for a resonance gas or a quark-gluon gas which undergoes fast hadronization and freeze-out. Qualitative agreement is found with comparable scaled p+p measurements and a heavy ion jet interaction generation model calculation based on independent particle collisions, although a small deviation from the 1/N scaling dependence expected from this model is observed.alle Autoren: J. Adams, C. Adler, M. M. Aggarwal, Z. Ahammed, J. Amonett, B. D. Anderson, M. Anderson, D. Arkhipkin, G. S. Averichev, S. K. Badyal, J. Balewski, O. Barannikova, L. S. Barnby, J. Baudot, S. Bekele, V. V. Belaga, R. Bellwied, J. Berger, B. I. Bezverkhny, S. Bhardwaj, P. Bhaskar, A. K. Bhati, H. Bichsel, A. Billmeier, L. C. Bland, C. O. Blyth, B. E. Bonner, M. Botje, A. Boucham, A. Brandin, A. Bravar, R. V. Cadman, X. Z. Cai, H. Caines, M. Calderón de la Barca Sánchez, A. Cardenas, J. Carroll, J. Castillo, M. Castro, D. Cebra, P. Chaloupka, S. Chattopadhyay, H. F. Chen, Y. Chen, S. P. Chernenko, M. Cherney, A. Chikanian, B. Choi, W. Christie, J. P. Coffin, T. M. Cormier, J. G. Cramer, H. J. Crawford, D. Das, S. Das, A. A. Derevschikov, L. Didenko, T. Dietel, X. Dong, J. E. Draper, F. Du, A. K. Dubey, V. B. Dunin, J. C. Dunlop, M. R. Dutta Majumdar, V. Eckardt, L. G. Efimov, V. Emelianov, J. Engelage, G. Eppley, B. Erazmus, P. Fachini, V. Faine, J. Faivre, R. Fatemi, K. Filimonov, P. Filip, E. Finch, Y. Fisyak, D. Flierl, K. J. Foley, J. Fu, C. A. Gagliardi, M. S. Ganti, T. D. Gutierrez, N. Gagunashvili, J. Gans, L. Gaudichet, M. Germain, F. Geurts, V. Ghazikhanian, P. Ghosh, J. E. Gonzalez, O. Grachov, V. Grigoriev, S. Gronstal, D. Grosnick, M. Guedon, S. M. Guertin, A. Gupta, E. Gushin, T. J. Hallman, D. Hardtke, J. W. Harris, M. Heinz, T. W. Henry, S. Heppelmann, T. Herston, B. Hippolyte, A. Hirsch, E. Hjort, G. W. Hoffmann, M. Horsley, H. Z. Huang, S. L. Huang, T. J. Humanic, G. Igo, A. Ishihara, P. Jacobs, W. W. Jacobs, M. Janik, I. Johnson, P. G. Jones, E. G. Judd, S. Kabana, M. Kaneta, M. Kaplan, D. Keane, J. Kiryluk, A. Kisiel, J. Klay, S. R. Klein, A. Klyachko, D. D. Koetke, T. Kolleger, A. S. Konstantinov, M. Kopytine, L. Kotchenda, A. D. Kovalenko, M. Kramer, P. Kravtsov, K. Krueger, C. Kuhn, A. I. Kulikov, A. Kumar, G. J. Kunde, C. L. Kunz, R. Kh. Kutuev, A. A. Kuznetsov, M. A. C. Lamont, J. M. Landgraf, S. Lange, C. P. Lansdell, B. Lasiuk, F. Laue, J. Lauret, A. Lebedev, R. Lednický, V. M. Leontiev, M. J. LeVine, C. Li, Q. Li, S. J. Lindenbaum, M. A. Lisa, F. Liu, L. Liu, Z. Liu, Q. J. Liu, T. Ljubicic, W. J. Llope, H. Long, R. S. Longacre, M. Lopez-Noriega, W. A. Love, T. Ludlam, D. Lynn, J. Ma, Y. G. Ma, D. Magestro, S. Mahajan, L. K. Mangotra, D. P. Mahapatra, R. Majka, R. Manweiler, S. Margetis, C. Markert, L. Martin, J. Marx, H. S. Matis, Yu. A. Matulenko, T. S. McShane, F. Meissner, Yu. Melnick, A. Meschanin, M. Messer, M. L. Miller, Z. Milosevich, N. G. Minaev, C. Mironov, D. Mishra, J. Mitchell, B. Mohanty, L. Molnar, C. F. Moore, M. J. Mora-Corral, V. Morozov, M. M. de Moura, M. G. Munhoz, B. K. Nandi, S. K. Nayak, T. K. Nayak, J. M. Nelson, P. Nevski, V. A. Nikitin, L. V. Nogach, B. Norman, S. B. Nurushev, G. Odyniec, A. Ogawa, V. Okorokov, M. Oldenburg, D. Olson, G. Paic, S. U. Pandey, S. K. Pal, Y. Panebratsev, S. Y. Panitkin, A. I. Pavlinov, T. Pawlak, V. Perevoztchikov, W. Peryt, V. A. Petrov, S. C. Phatak, R. Picha, M. Planinic, J. Pluta, N. Porile, J. Porter, A. M. Poskanzer, M. Potekhin, E. Potrebenikova, B. V. K. S. Potukuchi, D. Prindle, C. Pruneau, J. Putschke, G. Rai, G. Rakness, R. Raniwala, S. Raniwala, O. Ravel, S. V. Razin, D. Reichhold, J. G. Reid, G. Renault, F. Retiere, A. Ridiger, H. G. Ritter, J. B. Roberts, O. V. Rogachevski, J. L. Romero, A. Rose, C. Roy, L. J. Ruan, V. Rykov, R. Sahoo, I. Sakrejda, S. Salur, J. Sandweiss, I. Savin, J. Schambach, R. P. Scharenberg, N. Schmitz, L. S. Schroeder, K. Schweda, J. Seger, D. Seliverstov, P. Seyboth, E. Shahaliev, M. Shao, M. Sharma, K. E. Shestermanov, S. S. Shimanskii, R. N. Singaraju, F. Simon, G. Skoro, N. Smirnov, R. Snellings, G. Sood, P. Sorensen, J. Sowinski, H. M. Spinka, B. Srivastava, S. Stanislaus, R. Stock, A. Stolpovsky, M. Strikhanov, B. Stringfellow, C. Struck, A. A. P. Suaide, E. Sugarbaker, C. Suire, M. Šumbera, B. Surrow, T. J. M. Symons, A. Szanto de Toledo, P. Szarwas, A. Tai, J. Takahashi, A. H. Tang, D. Thein, J. H. Thomas, V. Tikhomirov, M. Tokarev, M. B. Tonjes, S. Trentalange, R. E. Tribble, M. D. Trivedi, V. Trofimov, O. Tsai, T. Ullrich, D. G. Underwood, G. Van Buren, A. M. VanderMolen, A. N. Vasiliev, M. Vasiliev, S. E. Vigdor, Y. P. Viyogi, S. A. Voloshin, W. Waggoner, F. Wang, G. Wang, X. L. Wang, Z. M. Wang, H. Ward, J. W. Watson, R. Wells, G. D. Westfall, C. Whitten, Jr., H. Wieman, R. Willson, S. W. Wissink, R. Witt, J. Wood, J. Wu, N. Xu, Z. Xu, Z. Z. Xu, A. E. Yakutin, E. Yamamoto, J. Yang, P. Yepes, V. I. Yurevich, Y. V. Zanevski, I. Zborovský, H. Zhang, H. Y. Zhang, W. M. Zhang, Z. P. Zhang, P. A. Zo&#322;nierczuk, R. Zoulkarneev, J. Zoulkarneeva, and A. N. Zubare

Pion-kaon correlations in central Au+Au collisions at sqrt[sNN]=130 GeV

Pion-kaon correlation functions are constructed from central Au+Au STAR data taken at sqrt[sNN]=130 GeV by the STAR detector at the Relativistic Heavy Ion Collider (RHIC). The results suggest that pions and kaons are not emitted at the same average space-time point. Space-momentum correlations, i.e., transverse flow, lead to a space-time emission asymmetry of pions and kaons that is consistent with the data. This result provides new independent evidence that the system created at RHIC undergoes a collective transverse expansion.alle Autoren: J. Adams, C. Adler, M. M. Aggarwal, Z. Ahammed, J. Amonett, B. D. Anderson, M. Anderson, D. Arkhipkin, G. S. Averichev, S. K. Badyal, J. Balewski, O. Barannikova, L. S. Barnby, J. Baudot, S. Bekele, V. V. Belaga, R. Bellwied, J. Berger, B. I. Bezverkhny, S. Bhardwaj, P. Bhaskar, A. K. Bhati, H. Bichsel, A. Billmeier, L. C. Bland, C. O. Blyth, B. E. Bonner, M. Botje, A. Boucham, A. Brandin, A. Bravar, R. V. Cadman, X. Z. Cai, H. Caines, M. Calderón de la Barca Sánchez, J. Carroll, J. Castillo, M. Castro, D. Cebra, P. Chaloupka, S. Chattopadhyay, H. F. Chen, Y. Chen, S. P. Chernenko, M. Cherney, A. Chikanian, B. Choi, W. Christie, J. P. Coffin, T. M. Cormier, J. G. Cramer, H. J. Crawford, D. Das, S. Das, A. A. Derevschikov, L. Didenko, T. Dietel, X. Dong, J. E. Draper, F. Du, A. K. Dubey, V. B. Dunin, J. C. Dunlop, M. R. Dutta Majumdar, V. Eckardt, L. G. Efimov, V. Emelianov, J. Engelage, G. Eppley, B. Erazmus, P. Fachini, V. Faine, J. Faivre, R. Fatemi, K. Filimonov, P. Filip, E. Finch, Y. Fisyak, D. Flierl, K. J. Foley, J. Fu, C. A. Gagliardi, M. S. Ganti, T. D. Gutierrez, N. Gagunashvili, J. Gans, L. Gaudichet, M. Germain, F. Geurts, V. Ghazikhanian, P. Ghosh, J. E. Gonzalez, O. Grachov, V. Grigoriev, S. Gronstal, D. Grosnick, M. Guedon, S. M. Guertin, A. Gupta, E. Gushin, T. J. Hallman, D. Hardtke, J. W. Harris, M. Heinz, T. W. Henry, S. Heppelmann, T. Herston, B. Hippolyte, A. Hirsch, E. Hjort, G. W. Hoffmann, M. Horsley, H. Z. Huang, S. L. Huang, T. J. Humanic, G. Igo, A. Ishihara, P. Jacobs, W. W. Jacobs, M. Janik, I. Johnson, P. G. Jones, E. G. Judd, S. Kabana, M. Kaneta, M. Kaplan, D. Keane, J. Kiryluk, A. Kisiel, J. Klay, S. R. Klein, A. Klyachko, D. D. Koetke, T. Kollegger, A. S. Konstantinov, M. Kopytine, L. Kotchenda, A. D. Kovalenko, M. Kramer, P. Kravtsov, K. Krueger, C. Kuhn, A. I. Kulikov, A. Kumar, G. J. Kunde, C. L. Kunz, R. Kh. Kutuev, A. A. Kuznetsov, M. A. C. Lamont, J. M. Landgraf, S. Lange, C. P. Lansdell, B. Lasiuk, F. Laue, J. Lauret, A. Lebedev, R. Lednický, V. M. Leontiev, M. J. LeVine, C. Li, Q. Li, S. J. Lindenbaum, M. A. Lisa, F. Liu, L. Liu, Z. Liu, Q. J. Liu, T. Ljubicic, W. J. Llope, H. Long, R. S. Longacre, M. Lopez-Noriega, W. A. Love, T. Ludlam, D. Lynn, J. Ma, Y. G. Ma, D. Magestro, S. Mahajan, L. K. Mangotra, D. P. Mahapatra, R. Majka, R. Manweiler, S. Margetis, C. Markert, L. Martin, J. Marx, H. S. Matis, Yu. A. Matulenko, T. S. McShane, F. Meissner, Yu. Melnick, A. Meschanin, M. Messer, M. L. Miller, Z. Milosevich, N. G. Minaev, C. Mironov, D. Mishra, J. Mitchell, B. Mohanty, L. Molnar, C. F. Moore, M. J. Mora-Corral, V. Morozov, M. M. de Moura, M. G. Munhoz, B. K. Nandi, S. K. Nayak, T. K. Nayak, J. M. Nelson, P. Nevski, V. A. Nikitin, L. V. Nogach, B. Norman, S. B. Nurushev, G. Odyniec, A. Ogawa, V. Okorokov, M. Oldenburg, D. Olson, G. Paic, S. U. Pandey, S. K. Pal, Y. Panebratsev, S. Y. Panitkin, A. I. Pavlinov, T. Pawlak, V. Perevoztchikov, W. Peryt, V. A. Petrov, S. C. Phatak, R. Picha, M. Planinic, J. Pluta, N. Porile, J. Porter, A. M. Poskanzer, M. Potekhin, E. Potrebenikova, B. V. K. S. Potukuchi, D. Prindle, C. Pruneau, J. Putschke, G. Rai, G. Rakness, R. Raniwala, S. Raniwala, O. Ravel, R. L. Ray, S. V. Razin, D. Reichhold, J. G. Reid, G. Renault, F. Retiere, A. Ridiger, H. G. Ritter, J. B. Roberts, O. V. Rogachevski, J. L. Romero, A. Rose, C. Roy, L. J. Ruan, V. Rykov, R. Sahoo, I. Sakrejda, S. Salur, J. Sandweiss, I. Savin, J. Schambach, R. P. Scharenberg, N. Schmitz, L. S. Schroeder, K. Schweda, J. Seger, D. Seliverstov, P. Seyboth, E. Shahaliev, M. Shao, M. Sharma, K. E. Shestermanov, S. S. Shimanskii, R. N. Singaraju, F. Simon, G. Skoro, N. Smirnov, R. Snellings, G. Sood, P. Sorensen, J. Sowinski, H. M. Spinka, B. Srivastava, S. Stanislaus, R. Stock, A. Stolpovsky, M. Strikhanov, B. Stringfellow, C. Struck, A. A. P. Suaide, E. Sugarbaker, C. Suire, M. Šumbera, B. Surrow, T. J. M. Symons, A. Szanto de Toledo, P. Szarwas, A. Tai, J. Takahashi, A. H. Tang, D. Thein, J. H. Thomas, V. Tikhomirov, M. Tokarev, M. B. Tonjes, T. A. Trainor, S. Trentalange, R. E. Tribble, M. D. Trivedi, V. Trofimov, O. Tsai, T. Ullrich, D. G. Underwood, G. Van Buren, A. M. VanderMolen, A. N. Vasiliev, M. Vasiliev, S. E. Vigdor, Y. P. Viyogi, S. A. Voloshin, W. Waggoner, F. Wang, G. Wang, X. L. Wang, Z. M. Wang, H. Ward, J. W. Watson, R. Wells, G. D. Westfall, C. Whitten, Jr., H. Wieman, R. Willson, S. W. Wissink, R. Witt, J. Wood, J. Wu, N. Xu, Z. Xu, Z. Z. Xu, A. E. Yakutin, E. Yamamoto, J. Yang, P. Yepes, V. I. Yurevich, Y. V. Zanevski, I. Zborovský, H. Zhang, H. Y. Zhang, W. M. Zhang, Z. P. Zhang, P. A. &#379;o&#322;nierczuk, R. Zoulkarneev, J. Zoulkarneeva, and A. N. Zubarev (STAR Collaboration

Transverse-momentum and collision-energy dependence of high-pT hadron suppression in Au+Au collisions at ultrarelativistic energies

We report high statistics measurements of inclusive charged hadron production in Au+Au and p+p collisions at sqrt[sNN]=200 GeV. A large, approximately constant hadron suppression is observed in central Au+Au collisions for 5<pT<12 GeV/c. The collision energy dependence of the yields and the centrality and pT dependence of the suppression provide stringent constraints on theoretical models of suppression. Models incorporating initial-state gluon saturation or partonic energy loss in dense matter are largely consistent with observations. We observe no evidence of pT-dependent suppression, which may be expected from models incorporating jet attenuation in cold nuclear matter or scattering of fragmentation hadrons.Alle Autoren: J. Adams, C. Adler, M. M. Aggarwal, Z. Ahammed, J. Amonett, B. D. Anderson, M. Anderson, D. Arkhipkin, G. S. Averichev, S. K. Badyal, J. Balewski, O. Barannikova, L. S. Barnby, J. Baudot, S. Bekele, V. V. Belaga, R. Bellwied, J. Berger, B. I. Bezverkhny, S. Bhardwaj, P. Bhaskar, A. K. Bhati, H. Bichsel, A. Billmeier, L. C. Bland, C. O. Blyth, B. E. Bonner, M. Botje, A. Boucham, A. Brandin, A. Bravar, R. V. Cadman, X. Z. Cai, H. Caines, M. Calderón de la Barca Sánchez, J. Carroll, J. Castillo, M. Castro, D. Cebra, P. Chaloupka, S. Chattopadhyay, H. F. Chen, Y. Chen, S. P. Chernenko, M. Cherney, A. Chikanian, B. Choi, W. Christie, J. P. Coffin, T. M. Cormier, J. G. Cramer, H. J. Crawford, D. Das, S. Das, A. A. Derevschikov, L. Didenko, T. Dietel, X. Dong, J. E. Draper, K. A. Drees, F. Du, A. K. Dubey, V. B. Dunin, J. C. Dunlop, M. R. Dutta Majumdar, V. Eckardt, L. G. Efimov, V. Emelianov, J. Engelage, G. Eppley, B. Erazmus, P. Fachini, V. Faine, J. Faivre, R. Fatemi, K. Filimonov, P. Filip, E. Finch, Y. Fisyak, D. Flierl, K. J. Foley, J. Fu, C. A. Gagliardi, M. S. Ganti, N. Gagunashvili, J. Gans, L. Gaudichet, M. Germain, F. Geurts, V. Ghazikhanian, P. Ghosh, J. E. Gonzalez, O. Grachov, V. Grigoriev, S. Gronstal, D. Grosnick, M. Guedon, S. M. Guertin, A. Gupta, E. Gushin, T. D. Gutierrez, T. J. Hallman, D. Hardtke, J. W. Harris, M. Heinz, T. W. Henry, S. Heppelmann, T. Herston, B. Hippolyte, A. Hirsch, E. Hjort, G. W. Hoffmann, M. Horsley, H. Z. Huang, S. L. Huang, T. J. Humanic, G. Igo, A. Ishihara, P. Jacobs, W. W. Jacobs, M. Janik, I. Johnson, P. G. Jones, E. G. Judd, S. Kabana, M. Kaneta, M. Kaplan, D. Keane, J. Kiryluk, A. Kisiel, J. Klay, S. R. Klein, A. Klyachko, T. Kollegger, A. S. Konstantinov, M. Kopytine, L. Kotchenda, A. D. Kovalenko, M. Kramer, P. Kravtsov, K. Krueger, C. Kuhn, A. I. Kulikov, A. Kumar, G. J. Kunde, C. L. Kunz, R. Kh. Kutuev, A. A. Kuznetsov, M. A. C. Lamont, J. M. Landgraf, S. Lange, C. P. Lansdell, B. Lasiuk, F. Laue, J. Lauret, A. Lebedev, R. Lednický, V. M. Leontiev, M. J. LeVine, C. Li, Q. Li, S. J. Lindenbaum, M. A. Lisa, F. Liu, L. Liu, Z. Liu, Q. J. Liu, T. Ljubicic, W. J. Llope, H. Long, R. S. Longacre, M. Lopez-Noriega, W. A. Love, T. Ludlam, D. Lynn, J. Ma, Y. G. Ma, D. Magestro, S. Mahajan, L. K. Mangotra, D. P. Mahapatra, R. Majka, R. Manweiler, S. Margetis, C. Markert, L. Martin, J. Marx, H. S. Matis, Yu. A. Matulenko, T. S. McShane, F. Meissner, Yu. Melnick, A. Meschanin, M. Messer, M. L. Miller, Z. Milosevich, N. G. Minaev, C. Mironov, D. Mishra, J. Mitchell, B. Mohanty, L. Molnar, C. F. Moore, M. J. Mora-Corral, V. Morozov, M. M. de Moura, M. G. Munhoz, B. K. Nandi, S. K. Nayak, T. K. Nayak, J. M. Nelson, P. Nevski, V. A. Nikitin, L. V. Nogach, B. Norman, S. B. Nurushev, G. Odyniec, A. Ogawa, V. Okorokov, M. Oldenburg, D. Olson, G. Paic, S. U. Pandey, S. K. Pal, Y. Panebratsev, S. Y. Panitkin, A. I. Pavlinov, T. Pawlak, V. Perevoztchikov, W. Peryt, V. A. Petrov, S. C. Phatak, R. Picha, M. Planinic, J. Pluta, N. Porile, J. Porter, A. M. Poskanzer, M. Potekhin, E. Potrebenikova, B. V. K. S. Potukuchi, D. Prindle, C. Pruneau, J. Putschke, G. Rai, G. Rakness, R. Raniwala, S. Raniwala, O. Ravel, R. L. Ray, S. V. Razin, D. Reichhold, J. G. Reid, G. Renault, F. Retiere, A. Ridiger, H. G. Ritter, J. B. Roberts, O. V. Rogachevski, J. L. Romero, A. Rose, C. Roy, L. J. Ruan, V. Rykov, R. Sahoo, I. Sakrejda, S. Salur, J. Sandweiss, I. Savin, J. Schambach, R. P. Scharenberg, N. Schmitz, L. S. Schroeder, K. Schweda, J. Seger, D. Seliverstov, P. Seyboth, E. Shahaliev, M. Shao, M. Sharma, K. E. Shestermanov, S. S. Shimanskii, R. N. Singaraju, F. Simon, G. Skoro, N. Smirnov, R. Snellings, G. Sood, P. Sorensen, J. Sowinski, H. M. Spinka, B. Srivastava, S. Stanislaus, R. Stock, A. Stolpovsky, M. Strikhanov, B. Stringfellow, C. Struck, A. A. P. Suaide, E. Sugarbaker, C. Suire, M. Šumbera, B. Surrow, T. J. M. Symons, A. Szanto de Toledo, P. Szarwas, A. Tai, J. Takahashi, A. H. Tang, D. Thein, J. H. Thomas, V. Tikhomirov, M. Tokarev, M. B. Tonjes, T. A. Trainor, S. Trentalange, R. E. Tribble, M. D. Trivedi, V. Trofimov, O. Tsai, T. Ullrich, D. G. Underwood, G. Van Buren, A. M. VanderMolen, A. N. Vasiliev, M. Vasiliev, S. E. Vigdor, Y. P. Viyogi, S. A. Voloshin, W. Waggoner, F. Wang, G. Wang, X. L. Wang, Z. M. Wang, H. Ward, J. W. Watson, R. Wells, G. D. Westfall, C. Whitten, Jr., H. Wieman, R. Willson, S. W. Wissink, R. Witt, J. Wood, J. Wu, N. Xu, Z. Xu, Z. Z. Xu, A. E. Yakutin, E. Yamamoto, J. Yang, P. Yepes, V. I. Yurevich, Y. V. Zanevski, I. Zborovský, H. Zhang, H. Y. Zhang, W. M. Zhang, Z. P. Zhang, P. A. &#379;o&#322;nierczuk, R. Zoulkarneev, J. Zoulkarneeva, and A. N. Zubarev (STAR Collaboration

Evidence from d+Au measurements for final-state suppression of high-pT hadrons in Au+Au collisions at RHIC

We report measurements of single-particle inclusive spectra and two-particle azimuthal distributions of charged hadrons at high transverse momentum (high pT) in minimum bias and central d+Au collisions at sqrt[sNN]=200 GeV. The inclusive yield is enhanced in d+Au collisions relative to binary-scaled p+p collisions, while the two-particle azimuthal distributions are very similar to those observed in p+p collisions. These results demonstrate that the strong suppression of the inclusive yield and back-to-back correlations at high pT previously observed in central Au+Au collisions are due to final-state interactions with the dense medium generated in such collisions.alle Autoren: J. Adams, C. Adler, M. M. Aggarwal, Z. Ahammed, J. Amonett, B. D. Anderson, M. Anderson, D. Arkhipkin, G. S. Averichev, S. K. Badyal, J. Balewski, O. Barannikova,, L. S. Barnby, J. Baudot, S. Bekele, V. V. Belaga, R. Bellwied, J. Berger, B. I. Bezverkhny, S. Bhardwaj, P. Bhaskar, A. K. Bhati, H. Bichsel, A. Billmeier, L. C. Bland, C. O. Blyth, B. E. Bonner, M. Botje, A. Boucham, A. Brandin, A. Bravar, R. V. Cadman, X. Z. Cai, H. Caines, M. Calderón de la Barca Sánchez, J. Carroll, J. Castillo, M. Castro, D. Cebra, P. Chaloupka, S. Chattopadhyay, H. F. Chen, Y. Chen, S. P. Chernenko, M. Cherney, A. Chikanian, B. Choi, W. Christie, J. P. Coffin, T. M. Cormier, J. G. Cramer, H. J. Crawford, D. Das, S. Das, A. A. Derevschikov, L. Didenko, T. Dietel, X. Dong,, J. E. Draper, F. Du, A. K. Dubey, V. B. Dunin, J. C. Dunlop, M. R. Dutta Majumdar, V. Eckardt, L. G. Efimov, V. Emelianov, J. Engelage, G. Eppley, B. Erazmus, P. Fachini, V. Faine, J. Faivre, R. Fatemi, K. Filimonov, P. Filip, E. Finch, Y. Fisyak, D. Flierl, K. J. Foley, J. Fu, C. A. Gagliardi, M. S. Ganti, N. Gagunashvili, J. Gans, L. Gaudichet, M. Germain, F. Geurts, V. Ghazikhanian, P. Ghosh, J. E. Gonzalez, O. Grachov, V. Grigoriev, S. Gronstal, D. Grosnick, M. Guedon, S. M. Guertin, A. Gupta, E. Gushin, T. D. Gutierrez, T. J. Hallman, D. Hardtke, J. W. Harris, M. Heinz, T. W. Henry, S. Heppelmann, T. Herston, B. Hippolyte, A. Hirsch, E. Hjort, G. W. Hoffmann, M. Horsley, H. Z. Huang, S. L. Huang, T. J. Humanic, G. Igo, A. Ishihara, P. Jacobs, W. W. Jacobs, M. Janik, I. Johnson, P. G. Jones, E. G. Judd, S. Kabana, M. Kaneta, M. Kaplan, D. Keane, J. Kiryluk, A. Kisiel, J. Klay, S. R. Klein, A. Klyachko, D. D. Koetke, T. Kollegger, A. S. Konstantinov, M. Kopytine, L. Kotchenda, A. D. Kovalenko, M. Kramer, P. Kravtsov, K. Krueger, C. Kuhn, A. I. Kulikov, A. Kumar, G. J. Kunde, C. L. Kunz, R. Kh. Kutuev, A. A. Kuznetsov, M. A. C. Lamont, J. M. Landgraf, S. Lange, C. P. Lansdell, B. Lasiuk, F. Laue, J. Lauret, A. Lebedev, R. Lednický, V. M. Leontiev, M. J. LeVine, C. Li, Q. Li, S. J. Lindenbaum, M. A. Lisa, F. Liu, L. Liu, Z. Liu, Q. J. Liu, T. Ljubicic, W. J. Llope, H. Long, R. S. Longacre, M. Lopez-Noriega, W. A. Love, T. Ludlam, D. Lynn, J. Ma, Y. G. Ma, D. Magestro, S. Mahajan, L. K. Mangotra, D. P. Mahapatra, R. Majka, R. Manweiler, S. Margetis, C. Markert, L. Martin, J. Marx, H. S. Matis, Yu. A. Matulenko, T. S. McShane, F. Meissner, Yu. Melnick, A. Meschanin, M. Messer, M. L. Miller, Z. Milosevich, N. G. Minaev, C. Mironov, D. Mishra, J. Mitchell, B. Mohanty, L. Molnar, C. F. Moore, M. J. Mora-Corral, V. Morozov, M. M. de Moura, M. G. Munhoz, B. K. Nandi, S. K. Nayak, T. K. Nayak, J. M. Nelson, P. Nevski, V. A. Nikitin, L. V. Nogach, B. Norman, S. B. Nurushev, G. Odyniec, A. Ogawa, V. Okorokov, M. Oldenburg, D. Olson, G. Paic, S. U. Pandey, S. K. Pal, Y. Panebratsev, S. Y. Panitkin, A. I. Pavlinov, T. Pawlak, V. Perevoztchikov, W. Peryt, V. A. Petrov, S. C. Phatak, R. Picha, M. Planinic, J. Pluta, N. Porile, J. Porter, A. M. Poskanzer, M. Potekhin, E. Potrebenikova, B. V. K. S. Potukuchi, D. Prindle, C. Pruneau, J. Putschke, G. Rai, G. Rakness, R. Raniwala, S. Raniwala, O. Ravel, R. L. Ray, S. V. Razin,, D. Reichhold, J. G. Reid, G. Renault, F. Retiere, A. Ridiger, H. G. Ritter, J. B. Roberts, O. V. Rogachevski, J. L. Romero, A. Rose, C. Roy, L. J. Ruan,, V. Rykov, R. Sahoo, I. Sakrejda, S. Salur, J. Sandweiss, I. Savin, J. Schambach, R. P. Scharenberg, N. Schmitz, L. S. Schroeder, K. Schweda, J. Seger, D. Seliverstov, P. Seyboth, E. Shahaliev, M. Shao, M. Sharma, K. E. Shestermanov, S. S. Shimanskii, R. N. Singaraju, F. Simon, G. Skoro, N. Smirnov, R. Snellings, G. Sood, P. Sorensen, J. Sowinski, H. M. Spinka, B. Srivastava, S. Stanislaus, R. Stock, A. Stolpovsky, M. Strikhanov, B. Stringfellow, C. Struck, A. A. P. Suaide, E. Sugarbaker, C. Suire, M. Šumbera, B. Surrow, T. J. M. Symons, A. Szanto de Toledo, P. Szarwas, A. Tai, J. Takahashi, A. H. Tang,, D. Thein, J. H. Thomas, V. Tikhomirov, M. Tokarev, M. B. Tonjes, T. A. Trainor, S. Trentalange, R. E. Tribble, M. D. Trivedi, V. Trofimov, O. Tsai, T. Ullrich, D. G. Underwood, G. Van Buren, A. M. VanderMolen, A. N. Vasiliev, M. Vasiliev, S. E. Vigdor, Y. P. Viyogi, S. A. Voloshin, W. Waggoner, F. Wang, G. Wang, X. L. Wang, Z. M. Wang, H. Ward, J. W. Watson, R. Wells, G. D. Westfall, C. Whitten, Jr., H. Wieman, R. Willson, S. W. Wissink, R. Witt, J. Wood, J. Wu, N. Xu, Z. Xu, Z. Z. Xu, A. E. Yakutin, E. Yamamoto, J. Yang, P. Yepes, V. I. Yurevich, Y. V. Zanevski, I. Zborovský, H. Zhang,, H. Y. Zhang, W. M. Zhang, Z. P. Zhang, P. A. &#379;o&#322;nierczuk, R. Zoulkarneev, J. Zoulkarneeva, and A. N. Zubarev (STAR Collaboration

Subcellular duplex DNA and G‐quadruplex interaction profiling of a hexagonal PtII metallacycle

[Abstract] Metal‐driven self‐assembly afforded a multitude of fascinating supramolecular coordination complexes (SCCs) with applications as catalysts, host–guest, and stimuli‐responsive systems. However, the interest in the biological applications of SCCs is only starting to emerge and thorough characterization of their behavior in biological milieus is still lacking. Herein, we report on the synthesis and detailed in‐cell tracking of a Pt2L2 metallacycle. We show that our hexagonal supramolecule accumulates in cancer cell nuclei, exerting a distinctive blue fluorescence staining of chromatin resistant to UV photobleaching selectively in nucleolar G4‐rich regions. SCC co‐localizes with epitopes of the quadruplex‐specific antibody BG4 and replaces other well‐known G4 stabilizers. Moreover, the photophysical changes accompanying the metallacycle binding to G4s in solution (fluorescence quenching, absorption enhancement) also take place intracellularly, allowing its subcellular interaction tracking.Ministerio de Economía, Industria y Competitividad; CTQ2016-75629-

Minimum Decision Cost for Quantum Ensembles

For a given ensemble of $N$ independent and identically prepared particles, we calculate the binary decision costs of different strategies for measurement of polarised spin 1/2 particles. The result proves that, for any given values of the prior probabilities and any number of constituent particles, the cost for a combined measurement is always less than or equal to that for any combination of separate measurements upon sub-ensembles. The Bayes cost, which is that associated with the optimal strategy (i.e., a combined measurement) is obtained in a simple closed form.Comment: 11 pages, uses RevTe