The molecular genetics of life satisfaction: Extending findings from a recent genome-wide association study and examining the role of the serotonin transporter

In a recent genome-wide association study (GWAS), three polymorphisms (rs3756290, RAPGEF6; rs2075677, CSE1L; rs4958581, NMUR2) were suggested as potentially being related to subjective-well-being and life satisfaction. Additionally, associations between the 5-HTTLPR polymorphism (serotonin transporter) and subjective well-being have been reported in other previous studies. In the current study, we therefore sought to further investigate the findings of the GWAS and examine the association between 5-HTTLPR and subjective well-being. A total of 1174 participants (821 females) were recruited and asked to provide information on their demographics, life satisfaction, and positive affect. All participants provided a genetic sample. We found associations between one SNP derived from the GWAS (rs4958581, NMUR2) and life satisfaction. We also replicated findings involving 5-HTTLPR and life satisfaction, but only for the housing, leisure and family life satisfaction variables, and not for overall life satisfaction or positive affect. Our study underlines that research investigating complex traits in the field of behavioral genetics is challenging due to their (a) pleiotropic and (b) polygenic effects, resulting in tiny effect sizes of each marker investigated. The current study also highlights the importance of investigating genetic markers of distinct areas of life satisfaction

Associations between the dark triad of personality and unspecified/specific forms of Internet-use disorder

Background and aims: Despite indications that the dark triad of personality might be associated with Internet-use disorder (IUD), research about these associations is lacking. Methods: Two studies were performed to grasp the links between these variables. In the first study, a sample consisting of N = 468 participants (n = 130 males) filled in the Short Dark Triad Questionnaire to assess scores in the dark triad of personality and the short Internet Addiction Test to assess tendencies toward unspecified IUD. In the second study, another independent sample of N = 472 participants (n = 143 males) filled in the same questionnaires plus items about specific forms of IUD. Results: Traits Machiavellianism and psychopathy were positively linked to tendencies toward unspecified IUD in both samples and males and females. Regarding the associations between tendencies toward specific IUDs and the dark triad of personality, no significant associations were found in males (at least not passing correction procedures for multiple testing). In females, trait Machiavellianism/psychopathy and tendencies toward Internet-shopping disorder, trait psychopathy, and tendencies toward Internet-pornography-use disorder as well as trait Machiavellianism and tendencies toward Internet-communication disorder were significantly positively correlated [at least one of the (sub)scales assessing the respective specific IUD was significantly associated with the respective dark triad trait even after correction procedures for multiple testing]. No robust pattern of associations between trait narcissism and unspecified/specific forms of IUD could be observed across (sub)samples. Discussion and conclusions: These results indicate positive associations of the traits Machiavellianism and psychopathy (on a subclinical level) with tendencies toward IUD, especially unspecified IUD. The associations with tendencies toward specific forms of IUD seem more complex with differential personality correlates for each specific IUD. These associations need to be replicated

The 2D:4D-Ratio and Neuroticism Revisited: Empirical Evidence from Germany and China

The 2D:4D-Ratio, as an indirect measure of the fetal testosterone to estradiol ratio, is potentially very important for understanding and explaining different personality traits. It was the aim of the present study to replicate the findings from Fink et al. (2004) about the relation between individual differences in 2D:4D-Ratios and the Five Factor Model in different cultural groups. Therefore a sample of n = 78 Chinese and n = 370 German participants was recruited. Every participant provided hand scans of both hands, from which 2D:4D-Ratios were computed. Moreover, all participants filled in the NEO Five Factor Inventory (NEO-FFI). Significant sex differences were found for ratios of both hands in the expected direction, with females showing higher ratios than males. With respect to links between personality and the digit ratio, a positive association was observed between 2D:4D-Ratio and Neuroticism in females, as shown in the earlier study. These findings were observed in both female subsamples from China and Germany, as well as in the full sample of participants. But in contrast to the results for the whole and the German female sample, where 2D:4D-Ratio of both hands were related to Neuroticism, in the Chinese female sample only left hand 2D:4D-Ratio was significantly and positively related to Neuroticism. There were no significant correlations found in any of the male samples. Thus, prenatal exposure to sex steroids appears to influence the personality factor Neuroticism in females specifically. This finding potentially has implications for mental health, as Neuroticism has been shown to be a risk factor for various forms of psychopathology

Temporary antimetabolite treatment hold boosts SARS-CoV-2 vaccination–specific humoral and cellular immunity in kidney transplant recipients

Transplant recipients exhibit an impaired protective immunity after SARS-CoV-2 vaccination, potentially caused by mycophenolate (MPA) immunosuppression. Recent data from patients with autoimmune disorders suggest that temporary MPA hold might greatly improve booster vaccination outcomes. We applied a fourth dose of SARS-CoV-2 vaccine to 29 kidney transplant recipients during a temporary (5 weeks) MPA/azathioprine hold, who had not mounted a humoral immune response to previous vaccinations. Seroconversion until day 32 after vaccination was observed in 76% of patients, associated with acquisition of virus-neutralizing capacity. Interestingly, 21/25 (84%) calcineurin inhibitor-treated patients responded, but only 1/4 belatacept-treated patients responded. In line with humoral responses. counts and relative frequencies of spike receptor binding domain-specific (RBD-specific) B cells were markedly increased on day 7 after vaccination, with an increase in RBD-specific CD27(++)CD38(+) plasmablasts. Whereas overall proportions of spike-reactive CD4(+) T cells remained unaltered after the fourth dose, frequencies were positively correlated with specific IgG levels. Importantly, antigen-specific proliferating Ki67(+) and in vivo-activated programmed cell death 1-positive T cells significantly increased after revaccination during MPA hold, whereas cytokine production and memory differentiation remained unaffected. In summary, antimetabolite hold augmented all arms of immunity during booster vaccination. These data suggest further studies of antimetabolite hold in kidney transplant recipients

Using Peer Support in Developing Empowering Mental Health Services (UPSIDES): Background, Rationale and Methodology

Background: Peers are people with lived experience of mental illness. Peer support is an established intervention in which peers offer support to others with mental illness. A large proportion of people living with severe mental illness receive no care. The care gap is largest in low- and middle-income countries, with detrimental effects on individuals and societies. The global shortage of human resources for mental health is an important driver of the care gap. Peers are an under-used resource in global mental health. Objectives: To describe rationale and methodology of an international multicentre study which will scale-up peer support for people with severe mental illness in high-, middle-, and low-income countries through mixed-methods implementation research. Methods: UPSIDES is an international community of research and practice for peer support, including peer support workers, mental health researchers, and other relevant stakeholders in eight study sites across six countries in Europe, Africa, and Asia. During the first two years of UPSIDES, a series of qualitative studies and systematic reviews will explore stakeholders’ perceptions and the current state of peer support at each site. Findings will be incorporated into a conceptual framework to guide the development of a culturally appropriate peer support intervention to be piloted across all study sites. All intervention and study materials will be translated according to internationally recognised guidelines. Expected Impact: UPSIDES: will leverage the unique expertise of people with lived experience of mental illness to strengthen mental health systems in high-, middle- and low-income countries. UPSIDES will actively involve and empower service users and embed patient-centeredness, recovery orientation, human rights approaches, and community participation into services. The focus on capacity-building of peers may prove particularly valuable in low-resource settings in which shortages of human capital are most severe

The association between frailty and MRI features of cerebral small vessel disease

Abstract: Frailty is a common syndrome in older individuals that is associated with poor cognitive outcome. The underlying brain correlates of frailty are unclear. The aim of this study was to investigate the association between frailty and MRI features of cerebral small vessel disease in a group of non-demented older individuals. We included 170 participants who were classified as frail (n = 30), pre-frail (n = 85) or non-frail (n = 55). The association of frailty and white matter hyperintensity volume and shape features, lacunar infarcts and cerebral perfusion was investigated by regression analyses adjusted for age and sex. Frail and pre-frail participants were older, more often female and showed higher white matter hyperintensity volume (0.69 [95%-CI 0.08 to 1.31], p = 0.03 respectively 0.43 [95%-CI: 0.04 to 0.82], p = 0.03) compared to non-frail participants. Frail participants showed a non-significant trend, and pre-frail participants showed a more complex shape of white matter hyperintensities (concavity index: 0.04 [95%-CI: 0.03 to 0.08], p = 0.03; fractal dimensions: 0.07 [95%-CI: 0.00 to 0.15], p = 0.05) compared to non-frail participants. No between group differences were found in gray matter perfusion or in the presence of lacunar infarcts. In conclusion, increased white matter hyperintensity volume and a more complex white matter hyperintensity shape may be structural brain correlates of the frailty phenotype

What Does Our Personality Say About Our Dietary Choices? Insights on the Associations Between Dietary Habits, Primary Emotional Systems and the Dark Triad of Personality

The awareness of the consequences of consuming animal products for the environment and one’s own health has been growing in recent years. The aim of the present research project was to examine the relationship between individual differences in biologically rooted primary emotional systems arising from phylogenetically old brain areas and dietary habits including being a vegan/vegetarian or omnivore (Study 1). Additionally, the link between the Dark Triad personality traits and dietary habits was investigated (also Study 1). In Study 2 it was aimed to replicate the associations between the Dark Triad traits and dietary habits in a new sample. In total 1140 (Study 1) and 444 (Study 2) participants took part in the research project. The Affective Neuroscience Personality Scales (ANPS) were applied to assess individual differences in six primary emotional systems. The Short Dark Triad Scale (SD3) was administered to assess individual differences in Machiavellianism, psychopathy and narcissism. The eating style of participants was measured with the Eating Behavior Questionnaire (EBQ). Results of Study 1 demonstrated higher CARE, SADNESS and spirituality scores, and lower PLAY scores in vegans/vegetarians than in omnivores. However, after the sex of the participants was included in the model, the effect on CARE got weaker. Additionally, omnivores scored higher on Machiavellianism, however, this association disappeared when sex was added to the model. In Study 2, higher scores in Machiavellianism, narcissism and psychopathy were reported for the group of omnivores compared to vegans/vegetarians, however, those effects got weaker or disappeared after the sex of participants was added to the model. The present research project adds to the literature by investigating the ANPS model and the Dark Triad of personality in the context of eating style for the first time. The findings of these two studies might help to better understand how people following different types of diet, might differ in their personalities.Peer Reviewe

Addictive Features of Social Media/Messenger Platforms and Freemium Games against the Background of Psychological and Economic Theories

Currently about 2.71 billion humans use a smartphone worldwide. Although smartphone technology has brought many advances, a growing number of scientists discuss potential detrimental effects due to excessive smartphone use. Of importance, the likely culprit to understand over-usage is not the smartphone itself, but the excessive use of applications installed on smartphones. As the current business model of many app-developers foresees an exchange of personal data for allowance to use an app, it is not surprising that many design elements can be found in social media apps and Freemium games prolonging app usage. It is the aim of the present work to analyze several prominent smartphone apps to carve out such elements. As a result of the analysis, a total of six different mechanisms are highlighted to illustrate the prevailing business model in smartphone app development. First, these app-elements are described and second linked to classic psychological/economic theories such as the mere-exposure effect, endowment effect, and Zeigarnik effect, but also to psychological mechanisms triggering social comparison. It is concluded that many of the here presented app-elements on smartphones are able to prolong usage time, but it is very hard to understand such an effect on the level of a single element. A systematic analysis would require insights into app data usually only being available for the app-designers, but not for independent scientists. Nevertheless, the present work supports the notion that it is time to critically reflect on the prevailing business model of ‘user data in exchange for app-use allowance’. Instead of using a service in exchange for data, it ultimately might be better to ban or regulate certain design elements in apps to come up with less addictive products. Instead, users could pay a reasonable fee for an app service

Commuting, Life-Satisfaction and Internet Addiction

The focus of the present work was on the association between commuting (business and private), life satisfaction, stress, and (over-) use of the Internet. Considering that digital devices are omnipresent in buses and trains, no study has yet investigated if commuting contributes to the development of Internet addiction. Overall, N = 5039 participants (N = 3477 females, age M = 26.79, SD = 10.68) took part in an online survey providing information regarding their commuting behavior, Internet addiction, personality, life satisfaction, and stress perception. Our findings are as follows: Personality seems to be less suitable to differentiate between commuter and non-commuter groups, which is possibly due to commuters often not having a choice but simply must accept offered job opportunities at distant locations. Second, the highest levels of satisfaction were found with income and lodging in the group commuting for business purposes. This might be related to the fact that commuting results in higher salaries (hence also better and more expensive housing style) due to having a job in another city which might exceed job opportunities at one’s own living location. Third, within the business-commuters as well as in the private-commuter groups, females had significantly higher levels of stress than males. This association was not present in the non-commuter group. For females, commuting seems to be a higher burden and more stressful than for males, regardless of whether they commute for business or private reasons. Finally, we observed an association between higher stress perception (more negative attitude towards commuting) and Internet addiction. This finding suggests that some commuters try to compensate their perceived stress with increased Internet use

Linking Internet Communication and Smartphone Use Disorder by taking a closer look at the Facebook and WhatsApp applications

Introduction: Smartphones are ubiquitous in the digital society. Although this powerful device is useful because it supports and simplifies many tasks in everyday life, a growing number of researchers is concerned that smartphones might have detrimental effects on the human brain and related psychological processes. Evidence indicates that social media platforms such as WhatsApp and Facebook are essential drivers of smartphone usage. Thus, a critical, yet unexplored issue is how excessive use of those platforms is related to Smartphone Use Disorder (SUD). Furthermore, since the roles of life satisfaction and fear of missing out (FoMo) have been demonstrated to be of particular importance for Internet Use and Internet Communication Disorder, those constructs were examined in the context of SUD. Methods: In total, n = 2299 participants filled in questionnaires assessing SUD, WhatsApp and Facebook Use Disorder, FoMO, life satisfaction, and reported owning a WhatsApp and Facebook account. Results: The study revealed that SUD was linked to WhatsApp Use Disorder, and to a lesser extent, to Facebook Use Disorder. Associations between SUD and WhatsApp Use Disorder were most strongly pronounced in females. Additionally, FoMo predicted SUD, WhatsApp, Facebook Use Disorder, and (fully) mediated the relationship between life satisfaction and those variables. Conclusion: The findings of the present study suggest that WhatsApp use plays an important role to understand SUD. Regarding the mediating role of FoMO, the present work might help disentangle inconsistent results on the link between life satisfaction and (excessive) social networking sites use. Keywords: Smartphone Use Disorder, Internet Communication Disorder, WhatsApp, Facebook, FoMo, Life satisfactio