Small perturbation of a disordered harmonic chain by a noise and an anharmonic potential

We study the thermal properties of a pinned disordered harmonic chain weakly perturbed by a noise and an anharmonic potential. The noise is controlled by a parameter λ → 0, and the anharmonicity by a parameter λ ≤ λ. Let κ be the conductivity of the chain, defined through the Green-Kubo formula. Under suitable hypotheses, we show that κ = O(λ) and, in the absence of anharmonic potential, that κ ∼ λ. This is in sharp contrast with the ordered chain for which κ ∼ 1/λ, and so shows the persistence of localization effects for a non-integrable dynamic

Drastic fall-off of the thermal conductivity for disordered lattices in the limit of weak anharmonic interactions

We study the thermal conductivity, at fixed positive temperature, of a disordered lattice of harmonic oscillators, weakly coupled to each other through anharmonic potentials. The interaction is controlled by a small parameter $\epsilon > 0$. We rigorously show, in two slightly different setups, that the conductivity has a non-perturbative origin. This means that it decays to zero faster than any polynomial in $\epsilon$ as $\epsilon\rightarrow 0$. It is then argued that this result extends to a disordered chain studied by Dhar and Lebowitz, and to a classical spins chain recently investigated by Oganesyan, Pal and Huse.Comment: 21 page

Hypoxia-Induced Adaptations of miRNomes and Proteomes in Melanoma Cells and Their Secreted Extracellular Vesicles

Reduced levels of intratumoural oxygen are associated with hypoxia-induced pro-oncogenic events such as invasion, metabolic reprogramming, epithelial–mesenchymal transition, metastasis and resistance to therapy, all favouring cancer progression. Small extracellular vesicles (EV) shuttle various cargos (proteins, miRNAs, DNA and others). Tumour-derived EVs can be taken up by neighbouring or distant cells in the tumour microenvironment, thus facilitating intercellular communication. The quantity of extracellular vesicle secretion and their composition can vary with changing microenvironmental conditions and disease states. Here, we investigated in melanoma cells the influence of hypoxia on the content and number of secreted EVs. Whole miRNome and proteome profiling revealed distinct expression patterns in normoxic or hypoxic growth conditions. Apart from the well-known miR-210, we identified miR-1290 as a novel hypoxia-associated microRNA, which was highly abundant in hypoxic EVs. On the other hand, miR-23a-5p and -23b-5p were consistently downregulated in hypoxic conditions, while the protein levels of the miR-23a/b-5p-predicted targetIPO11were concomitantly upregulated. Furthermore, hypoxic melanoma EVs exhibit a signature consisting of six proteins (AKR7A2, DDX39B, EIF3C, FARSA, PRMT5, VARS), which were significantly associated with a poor prognosis for melanoma patients, indicating that proteins and/or miRNAs secreted by cancer cells may be exploited as biomarkers

Enzymatic activity of glycosyltransferase GLT8D1 promotes human glioblastoma cell migration.

peer reviewedGlioblastoma (GBM) is the most aggressive primary brain tumor characterized by infiltrative growth of malignant glioma cells into the surrounding brain parenchyma. In this study, our analysis of GBM patient cohorts revealed a significantly higher expression of Glycosyltransferase 8 domain containing 1 (GLT8D1) compared to normal brain tissue and could be associated with impaired patient survival. Increased in vitro expression of GLT8D1 significantly enhanced migration of two different sphere-forming GBM cell lines. By in silico analysis we predicted the 3D-structure as well as the active site residues of GLT8D1. The introduction of point mutations in the predicted active site reduced its glycosyltransferase activity in vitro and consequently impaired GBM tumor cell migration. Examination of GLT8D1 interaction partners by LC-MS/MS implied proteins associated with cytoskeleton and intracellular transport as potential substrates. In conclusion, we demonstrated that the enzymatic activity of glycosyltransferase GLT8D1 promotes GBM cell migration

Tectonic evolution of the Rehamna metamorphic dome (Morocco) in the context of the Alleghanian-Variscan orogeny

Structural and 40Ar/39Ar geochronological investigations of the Rehamna Massif (Meseta, Moroccan Variscan belt) provide new constraints on the tectonic evolution of the Alleghanian-Variscan orogen during the Upper Paleozoic. Three main tectonic events have been recognized: (1) Southward thrusting of an Ordovician sequence over the Proterozoic basement, its Cambrian sedimentary cover, and the overlying Devono-Carboniferous basin. This event caused subhorizontal shearing and prograde Barrovian metamorphism of the buried rocks. (2) Continuous shortening resulting in the development of a synconvergent extrusion of metamorphosed units to form a dome elongated E-W. This was responsible for synconvergent detachment of the Ordovician upper crustal sequence. The timing of these two episodes is constrained to 310–295 Ma by cooling and metamorphic amphibole and mica ages (3) A NW-WNW convergence in a direction orthogonal to the previous one and characterized by the accretion of the Rehamna dome to the continental basement in the east. Based on 40Ar/39Ar cooling ages from a syntectonic granitoid and its host rocks and metamorphic 40Ar/39Ar ages from greenschist facies mylonite, the timing of this event falls between 295 and 280 Ma. The end of the Variscan orogeny in the Moroccan Meseta is constrained by the 40Ar/39Ar cooling age of a posttectonic pluton dated at ~275 Ma. The tectonic events highlighted in Morocco coincide with the late Variscan-Alleghanian tectonic evolution of southern Europe and North America and can be correlated with the global reorganization of plates that accompanied suturing of Pangaea at around 295 Ma.Peer reviewe

Comparison of the efficiency of various methods for the synthesis of models of metabolites: example of 4a-methylhexahydronaphtalenones

International audienc

Synthesis of models of metabolites: Oxidation of variously substituted chromenes including acronycine, by a porphyrin catalytic system

International audienc