Diabetes and Hypertension: Is There a Common Metabolic Pathway?

Diabetes and hypertension frequently occur together. There is substantial overlap between diabetes and hypertension in etiology and disease mechanisms. Obesity, inflammation, oxidative stress, and insulin resistance are thought to be the common pathways. Recent advances in the understanding of these pathways have provided new insights and perspectives. Physical activity plays an important protective role in the two diseases. Knowing the common causes and disease mechanisms allows a more effective and proactive approach in their prevention and treatment

Strings in Gravimagnetic Fields

We provide a complete solution of closed strings propagating in Nappi-Witten space. Based on the analysis of geodesics we construct the coherent wavefunctions which approximate as closely as possible the classical trajectories. We then present a new free field realization of the current algebra using the gamma, beta ghost system. Finally we construct the quantum vertex operators, for the tachyon, by representing the wavefunctions in terms of the free fields. This allows us to compute the three- and four-point amplitudes, and propose the general result for N-point tachyon scattering amplitude.Comment: final version, 29 pages + 4 app

The KCNJ11 E23K Polymorphism and Progression of Glycaemia in Southern Chinese: A Long-Term Prospective Study

Context: The KCNJ11 E23K variant is associated with type 2 diabetes mellitus (T2DM) in cross-sectional studies, but conflicting findings have been reported from prospective studies. Objective: This study aimed to evaluate whether the E23K variant could predict glycaemic progression in a Southern Chinese population. Methods/Principal Findings: We performed a long-term prospective study on 1912 subjects from the Hong Kong Cardiovascular Risk Factors Prevalence Study (CRISPS). The KCNJ11 E23K variant was associated with the progression to prediabetes after a median interval of 12 years on multinomial logistic regression analysis, even after adjustment for traditional risk factors (OR 1.29, P age, sex, BMI and fasting plasma glucose [FPG] adjusted = 0.02). Based on Cox proportional hazard regression analysis, the E23K variant also predicted incident prediabetes (HR 1.18, P age, sex, BMI and FPG adjusted = 0.021). However, E23K was not associated with the progression to T2DM in either multinomial or Cox regression analysis, and the association of E23K with glycaemic progression to either prediabetes or T2DM was significant only in unadjusted Cox regression analysis (P = 0.039). In a meta-analysis of eight prospective studies including our own, involving 15680 subjects, the E23K variant was associated with incident T2DM (fixed effect: OR 1.10, P = 4×10 -3; random effect: OR 1.11, P = 0.035). Conclusions: Our study has provided supporting evidence for the role of the E23K variant in glycaemic progression in Chinese, with its effect being more evident in the early stage of T2DM, as the subjects progressed from normal glucose tolerance to prediabetes. © 2011 Cheung et al.published_or_final_versio

Corrections to Chiral Dynamics of Heavy Hadrons: (I) 1/M Correction

In earlier publications we have analyzed the strong and radiative decays of heavy hadrons in a formalism which incorporates both heavy-quark and chiral symmetries. In particular, we have derived a heavy-hadron chiral Lagrangian whose coupling constants are related by the heavy-quark flavor-spin symmetry arising from the QCD Lagrangian with infinitely massive quarks. In this paper, we re-examine the structure of the above chiral Lagrangian by including the effects of $1/m_Q$ corrections in the heavy quark effective theory. The relations among the coupling constants, originally derived in the heavy-quark limit, are modified by heavy quark symmetry breaking interactions in QCD. Some of the implications are discussed.Comment: PHYZZX, 45 pages, 1 figure (not included), CLNS 93/1192, IP-ASTP-02-93, ITP-SB-93-0

Optimal Reinsurance with One Insurer and Multiple Reinsurers

In this paper, we consider a one-period optimal reinsurance design model with n reinsurers and an insurer. For very general preferences of the insurer, we obtain that there exists a very intuitive pricing formula for all reinsurers that use a distortion premium principle. The insurer determines its optimal risk that it wants to reinsure via this pricing formula. This risk it wants to reinsure is then shared by the reinsurers via tranching. The optimal ceded loss functions among multiple reinsurers are derived explicitly under the additional assumptions that the insurer’s preferences are given by an inverse-S shaped distortion risk measure and that the reinsurer’s premium principles are some functions of the Conditional Value-at-Risk. We also demonstrate that under some prescribed conditions, it is never optimal for the insurer to cede its risk to more than two reinsurers

Salespeople’s Renqing Orientation, Self-esteem, and Selling Behaviors: An Empirical Study in Taiwan

The purpose of this study was to investigate how salespeople’s renqing orientation and self-esteem jointly affect their selling behavior. Data were obtained from a survey of salespeople from 17 pharmaceutical and consumer-goods companies in Taiwan (n = 216). Salespeople’s renqing orientation (i.e., their propensity to adhere to the accepted norm of reciprocity) compensates the negative effect of self-esteem on their selling behaviors, such as adaptive selling and hard work. Our study results underscore the critical role of the character trait of renqing orientation in a culture emphasizing a norm of reciprocity. Therefore, it would be useful to consider a strategy of recruiting salespeople with either a high self-esteem or a combination of high renqing orientation and low self-esteem. The existing literature of industrial/organizational psychology and marketing primarily relies on constructs that are derived from Western cultural contexts. However, the present paper extended these literatures by investigating the possible joint effects of self-esteem with a trait originated from the Chinese culture on salespeople’s selling behaviors

Optimal Risk Transfers in Insurance Groups

Optimal risk transfers are derived within an insurance group consisting of two separate legal entities, operating under potentially different regulatory capital requirements and capital costs. Consistent with regulatory practice, capital requirements for each entity are computed by either a value-at-risk or an expected shortfall risk measure. The optimality criterion consists of minimising the risk-adjusted value of the total group liabilities, with valuation carried out using a cost-of-capital approach. The optimisation problems are analytically solved and it is seen that optimal risk transfers often involve the transfer of tail risk (unlimited reinsurance layers) to the more weakly regulated entity. We show that, in the absence of a capital requirement for the credit risk that specifically arises from the risk transfer, optimal risk transfers achieve capital efficiency at the cost of increasing policyholder deficit. However, when credit risk is properly reflected in the capital requirement, incentives for tail-risk transfers vanish and policyholder welfare is restored

Effective Field Theory of Heavy Mesons

In this paper we present a detailed formulation for a recently proposed effective field theory to describe the nonperturbative QCD dynamics of heavy mesons. This effective theory incorporates with heavy quark symmetry (HQS) and the heavy quark effective theory (HQET). Heavy mesons in this theory are constructed as composite particles of a heavy quark bounded with the light degrees of freedom. The heavy meson properties in the heavy quark limit and the $1/m_Q$ corrections can then be explicitly evaluated from this effective theory. All the basic parameters of the HQET, namely, the heavy quark mass $m_Q$, the heavy meson residual mass $\overline{\Lambda}$, and the HQS breaking mass parameters $\lambda_1$ and $\lambda_2$, are consistently determined. $\lambda_1$ is found to be small due to a large cancellation between the heavy quark kinetic energy and the chromo-electric interaction between the heavy quark and light degrees of freedom. We also evaluate the Isgur-Wise function, the decay constant, and the axial-vector coupling constant of heavy mesons.Comment: 33 pages, 4 figure