Beyond Yield Optimization: The Impact of Organosolv Process Parameters on Lignin Structure

When optimizing the process parameters of the acidic ethanolic organosolv process, the aim is usually to maximize the delignification and/or lignin purity. However, process parameters such as temperature, time, ethanol and catalyst concentration, respectively, can also be used to vary the structural properties of the obtained organosolv lignin, including the molecular weight and the ratio of aliphatic versus phenolic hydroxyl groups, among others. This review particularly focuses on these influencing factors and establishes a trend analysis between the variation of the process parameters and the effect on lignin structure. Especially when larger data sets are available, as for process temperature and time, correlations between the distribution of depolymerization and condensation reactions are found, which allow direct conclusions on the proportion of lignin's structural features, independent of the diversity of the biomass used. The newfound insights gained from this review can be used to tailor organosolv lignins isolated for a specific application

Tofacitinib versus Biologic Treatments in Moderate-to-Severe Rheumatoid Arthritis Patients Who Have Had an Inadequate Response to Nonbiologic DMARDs: Systematic Literature Review and Network Meta-Analysis

Objective. To compare the efficacy and tolerability of tofacitinib, an oral Janus kinase inhibitor for the treatment of rheumatoid arthritis (RA), as monotherapy and combined with disease-modifying antirheumatic drugs (DMARDs) versus biological DMARDs (bDMARDs) and other novel DMARDs for second-line moderate-to-severe rheumatoid arthritis (RA) patients by means of a systematic literature review (SLR) and network meta-analysis (NMA). Methods. MEDLINE®, EMBASE®, and Cochrane Central Register of Controlled Trials were searched to identify randomized clinical trials (RCTs) published between 1990 and March 2015. Efficacy data based on American College of Rheumatology (ACR) response criteria, improvements in the Health Assessment Questionnaire Disability Index (HAQ-DI) at 6 months, and discontinuation rates due to adverse events were analyzed by means of Bayesian NMAs. Results. 45 RCTs were identified, the majority of which demonstrated a low risk of bias. Tofacitinib 5 mg twice daily (BID) and 10 mg BID monotherapy exhibited comparable efficacy and discontinuation rates due to adverse events versus other monotherapies. Tofacitinib 5 mg BID and 10 mg BID + DMARDs or methotrexate (MTX) were mostly comparable to other combination therapies in terms of efficacy and discontinuation due to adverse events. Conclusion. In most cases, tofacitinib had similar efficacy and discontinuation rates due to adverse events compared to biologic DMARDs

Оптимизация процессов легирования силумина ионно-электронно-плазменным методом

The surface morphology, chemical composition, microstructure, nanohardness, and tribological properties of a film silumin on aluminum were investigated. The film (Al-25% Si) / substrate (Al-12% Si) has modificated by ion-electron-plasma method. The wear resistance and hardness of a slight increase in 1.3 times

(596) Scheila in outburst: a probable collision event in the main asteroid belt

Descripción basada en el artículo versión final de la editora. Texto completo versión preprint.Images of asteroid (596) Scheila have been acquired at various dates after the discovery of the 2010 outburst. Assuming a short-duration event scenario, as suggested by the quick vanishing of the dust tail brightness with time, and numerically integrating the equation of motion of individual particles ejected from the surface, we have developed a tail model from which we estimate the parameters associated with the geometry of the ejection, the size distribution, and the velocity distribution of the ejected particles, as well as the total mass ejected. We found a weak inverse power-law dependence of ejection velocity versus particle radius, with velocities ranging from 50 to 80 m s–1 for particle radii in the range from 5 cm to 8 × 10–5 cm, respectively. These velocities are very different from those expected from ice sublimation at the asteroid heliocentric distance (~3 AU) and suggest a collision scenario as a likely cause of the outburst. We found that the ejected particles are distributed in size following a power law of index -3, and, based on the ejecta mass and scaling laws, the impactor size is estimated at 30-90 m in radius, assuming an impact velocity of ~5 km s–1, and the same density (1500 kg m–3) for the asteroid as for the projectile. We have inferred an asymmetry in the ejecta along the axis normal to the asteroid orbit plane, a likely indicator of an oblique impact. The impact is estimated to have occurred on November 27, with an accuracy not better than ±3 days.Peer reviewe

Crisaborole Ointment, 2%, for Treatment of Patients with Mild-to-Moderate Atopic Dermatitis:Systematic Literature Review and Network Meta-Analysis

The authors would like to replace 2 small sections of the published manuscript that refer to a qualitative review of safety data for included studies (together with an associated safety table), to provide some further clarifications on these safety data and to include some quantitative updates for rates

Регулируемый электропривод конвейера Распадской обогатительной фабрики

Цель работы – разработка и исследование регулируемого электропривода ленточного конвейера. Произведен расчет конвейера и выбор основного электрооборудования, построены электромеханические и механические характеристики асинхронного электродвигателя. Построены переходные процессы для различных режимов работы.The work purpose – development and research of the adjustable electric drive of the tape conveyor. Calculation of the conveyor and the choice of the capital electric equipment is made, electromechanical and mechanical characteristics of the asynchronous electric motor are constructed. Transition processes for various operating modes are constructed

Feasibility of Prehospital Teleconsultation in Acute Stroke – A Pilot Study in Clinical Routine

BACKGROUND: Inter-hospital teleconsultation improves stroke care. To transfer this concept into the emergency medical service (EMS), the feasibility and effects of prehospital teleconsultation were investigated. METHODOLOGY/PRINCIPAL FINDINGS: Teleconsultation enabling audio communication, real-time video streaming, vital data and still picture transmission was conducted between an ambulance and a teleconsultation center. Pre-notification of the hospital was carried out with a 14-item stroke history checklist via e-mail-to-fax. Beside technical assessments possible influences on prehospital and initial in-hospital time intervals, prehospital diagnostic accuracy and the transfer of stroke specific data were investigated by comparing telemedically assisted prehospital care (telemedicine group) with local regular EMS care (control group). All prehospital stroke patients over a 5-month period were included during weekdays (7.30 a.m.-4.00 p.m.). In 3 of 18 missions partial dropouts of the system occurred; neurological co-evaluation via video transmission was conducted in 12 cases. The stroke checklist was transmitted in 14 cases (78%). Telemedicine group (n = 18) vs. control group (n = 47): Prehospital time intervals were comparable, but in both groups the door to brain imaging times were longer than recommended (median 59.5 vs. 57.5 min, p = 0.6447). The prehospital stroke diagnosis was confirmed in 61% vs. 67%, p = 0.8451. Medians of 14 (IQR 9) vs. 5 (IQR 2) stroke specific items were transferred in written form to the in-hospital setting, p<0.0001. In 3 of 10 vs. 5 of 27 patients with cerebral ischemia thrombolytics were administered, p = 0.655. CONCLUSIONS: Teleconsultation was feasible but technical performance and reliability have to be improved. The approach led to better stroke specific information; however, a superiority over regular EMS care was not found and in-hospital time intervals were unacceptably long in both groups. The feasibility of prehospital tele-stroke consultation has future potential to improve emergency care especially when no highly trained personnel are on-scene. TRIAL REGISTRATION: International Standard Randomised Controlled Trial Number Register (ISRCTN) ISRCTN83270177